Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening

Y. K. Huang, S. L. You, C. C. Yuan, Y. M. Ke, J. M. Cao, C. Y. Liao, C. H. Wu, C. S. Hsu, K. F. Huang, C. H. Lu, N. F. Twu, T. Y. Chu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Knowing that infection of high-risk human papillomavirus (HPV) causes virtually all cervical cancer (CC), the long-term outcomes of HPV infection, especially the absolute risk and time lapse of developing CC, are beyond the scope of ordinary follow-up study owing to ethical concerns. The present study followed the natural history and long-term outcomes of HPV infection in a cohort of women by national health insurance care and data linkage without additional disturbance. The status of cervical HPV infection was determined in 1708 healthy women, aged 20-90 (median 43), enrolled from 10 hospitals in seven cities around the island country of Taiwan. Records of consecutive Pap smear results and cancer reports of 108 cytology-negative, HPV-positive and 1202 cytology- and HPV-negative women with no prior record of CC or abnormal cervical cytology were retrospectively analysed for a duration of up to 75 months (median 61 months). The cumulative incidences of high-grade squamous intraepithelial lesion (HSIL) and in situ/invasive cancer in HPV-positive women were 5.6 and 3.7%, respectively, and those in HPV-negative women were 0.3 and 0%. After adjusting for other risk factors, HPV-positive subjects had 24.9 (95% CI: 7.0-108.3; P

Original languageEnglish
Pages (from-to)863-869
Number of pages7
JournalBritish Journal of Cancer
Volume98
Issue number5
DOIs
Publication statusPublished - Mar 11 2008
Externally publishedYes

Fingerprint

Papillomavirus Infections
Early Detection of Cancer
Uterine Cervical Neoplasms
Cell Biology
Papanicolaou Test
Information Storage and Retrieval
National Health Programs
Women's Health
Natural History
Taiwan
Islands
Neoplasms
Delivery of Health Care
Incidence

Keywords

  • Absolute risk
  • Cervical cancer
  • Human papillomavirus
  • Long-term follow-up

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening. / Huang, Y. K.; You, S. L.; Yuan, C. C.; Ke, Y. M.; Cao, J. M.; Liao, C. Y.; Wu, C. H.; Hsu, C. S.; Huang, K. F.; Lu, C. H.; Twu, N. F.; Chu, T. Y.

In: British Journal of Cancer, Vol. 98, No. 5, 11.03.2008, p. 863-869.

Research output: Contribution to journalArticle

Huang, YK, You, SL, Yuan, CC, Ke, YM, Cao, JM, Liao, CY, Wu, CH, Hsu, CS, Huang, KF, Lu, CH, Twu, NF & Chu, TY 2008, 'Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening', British Journal of Cancer, vol. 98, no. 5, pp. 863-869. https://doi.org/10.1038/sj.bjc.6604262
Huang, Y. K. ; You, S. L. ; Yuan, C. C. ; Ke, Y. M. ; Cao, J. M. ; Liao, C. Y. ; Wu, C. H. ; Hsu, C. S. ; Huang, K. F. ; Lu, C. H. ; Twu, N. F. ; Chu, T. Y. / Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening. In: British Journal of Cancer. 2008 ; Vol. 98, No. 5. pp. 863-869.
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