Long-term outcome of non-sustained ventricular tachycardia in structurally normal hearts

Chin Yu Lin, Shih Lin Chang, Fa Po Chung, Yun Yu Chen, Yenn Jiang Lin, Li Wei Lo, Yu Feng Hu, Ta Chuan Tuan, Tze Fan Chao, Jo Nan Liao, Yao Ting Chang, Chung-Hsing Lin, Suresh Allamsetty, Rohit Walia, Abigail Louise D Te, Shinya Yamada, Shuo Ju Chiang, Hsuan Ming Tsao, Shih Ann Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: The impact of non-sustained ventricular tachycardia (NSVT) on the risk of thromboembolic event and clinical outcomes in patients without structural heart disease remains undetermined. This study aimed to evaluate the association between NSVT and clinical outcomes. Methods: The study population of 5903 patients was culled from the "Registry of 24-hour ECG monitoring at Taipei Veterans General Hospital" (REMOTE database) between January 1, 2002 and December 31, 2004. Of that total, we enrolled 3767 patients without sustained ventricular tachycardia, structural heart disease, and permanent pacemaker. For purposes of this study, NSVT was defined as 3 or more consecutive beats arising below the atrioventricular node with an RR interval of <600 ms (>100 beats/min) and lasting < 30 seconds. Result: There were 776 deaths, 2042 hospitalizations for any reason, 638 cardiovascular (CV)-related hospitalizations, 350 ischemic strokes, 409 transient ischemic accident (TIA), 368 new-onset heart failure (HF), and 260 new-onset atrial fibrillation (AF) with a mean follow-up duration of 10 ± 1 years. In multivariate analysis, the presence of NSVT was independently associated with death (hazard ratio [HR]: 1.362, 95% confidence interval [CI]: 1.071-1.731), CV hospitalization (HR: 1.527, 95% CI: 1.171-1.992), ischemic stroke (HR: 1.436, 95% CI: 1.014-2.032), TIA (HR 1.483, 95% CI: 1.069-2.057), and new-onset HF (HR: 1.716, 95% CI: 1.243-2.368). There was no significant association between the presence of NSVT and all-cause hospitalization or new-onset AF. Conclusion: In patients without structural heart disease, presence of NSVT on 24-hour monitoring was independently associated with death, CV hospitalization, ischemic stroke, TIA, and new onset heart failure.

Original languageEnglish
Article numbere0160181
JournalPLoS One
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

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Ventricular Tachycardia
heart
Hazards
confidence interval
Hospitalization
Confidence Intervals
heart diseases
heart failure
accidents
stroke
Accidents
Heart Diseases
Heart Failure
Stroke
death
Atrial Fibrillation
Pacemakers
veterans
Monitoring
Veterans Hospitals

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lin, C. Y., Chang, S. L., Chung, F. P., Chen, Y. Y., Lin, Y. J., Lo, L. W., ... Chen, S. A. (2016). Long-term outcome of non-sustained ventricular tachycardia in structurally normal hearts. PLoS One, 11(8), [e0160181]. https://doi.org/10.1371/journal.pone.0160181

Long-term outcome of non-sustained ventricular tachycardia in structurally normal hearts. / Lin, Chin Yu; Chang, Shih Lin; Chung, Fa Po; Chen, Yun Yu; Lin, Yenn Jiang; Lo, Li Wei; Hu, Yu Feng; Tuan, Ta Chuan; Chao, Tze Fan; Liao, Jo Nan; Chang, Yao Ting; Lin, Chung-Hsing; Allamsetty, Suresh; Walia, Rohit; Te, Abigail Louise D; Yamada, Shinya; Chiang, Shuo Ju; Tsao, Hsuan Ming; Chen, Shih Ann.

In: PLoS One, Vol. 11, No. 8, e0160181, 01.08.2016.

Research output: Contribution to journalArticle

Lin, CY, Chang, SL, Chung, FP, Chen, YY, Lin, YJ, Lo, LW, Hu, YF, Tuan, TC, Chao, TF, Liao, JN, Chang, YT, Lin, C-H, Allamsetty, S, Walia, R, Te, ALD, Yamada, S, Chiang, SJ, Tsao, HM & Chen, SA 2016, 'Long-term outcome of non-sustained ventricular tachycardia in structurally normal hearts', PLoS One, vol. 11, no. 8, e0160181. https://doi.org/10.1371/journal.pone.0160181
Lin, Chin Yu ; Chang, Shih Lin ; Chung, Fa Po ; Chen, Yun Yu ; Lin, Yenn Jiang ; Lo, Li Wei ; Hu, Yu Feng ; Tuan, Ta Chuan ; Chao, Tze Fan ; Liao, Jo Nan ; Chang, Yao Ting ; Lin, Chung-Hsing ; Allamsetty, Suresh ; Walia, Rohit ; Te, Abigail Louise D ; Yamada, Shinya ; Chiang, Shuo Ju ; Tsao, Hsuan Ming ; Chen, Shih Ann. / Long-term outcome of non-sustained ventricular tachycardia in structurally normal hearts. In: PLoS One. 2016 ; Vol. 11, No. 8.
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abstract = "Background: The impact of non-sustained ventricular tachycardia (NSVT) on the risk of thromboembolic event and clinical outcomes in patients without structural heart disease remains undetermined. This study aimed to evaluate the association between NSVT and clinical outcomes. Methods: The study population of 5903 patients was culled from the {"}Registry of 24-hour ECG monitoring at Taipei Veterans General Hospital{"} (REMOTE database) between January 1, 2002 and December 31, 2004. Of that total, we enrolled 3767 patients without sustained ventricular tachycardia, structural heart disease, and permanent pacemaker. For purposes of this study, NSVT was defined as 3 or more consecutive beats arising below the atrioventricular node with an RR interval of <600 ms (>100 beats/min) and lasting < 30 seconds. Result: There were 776 deaths, 2042 hospitalizations for any reason, 638 cardiovascular (CV)-related hospitalizations, 350 ischemic strokes, 409 transient ischemic accident (TIA), 368 new-onset heart failure (HF), and 260 new-onset atrial fibrillation (AF) with a mean follow-up duration of 10 ± 1 years. In multivariate analysis, the presence of NSVT was independently associated with death (hazard ratio [HR]: 1.362, 95{\%} confidence interval [CI]: 1.071-1.731), CV hospitalization (HR: 1.527, 95{\%} CI: 1.171-1.992), ischemic stroke (HR: 1.436, 95{\%} CI: 1.014-2.032), TIA (HR 1.483, 95{\%} CI: 1.069-2.057), and new-onset HF (HR: 1.716, 95{\%} CI: 1.243-2.368). There was no significant association between the presence of NSVT and all-cause hospitalization or new-onset AF. Conclusion: In patients without structural heart disease, presence of NSVT on 24-hour monitoring was independently associated with death, CV hospitalization, ischemic stroke, TIA, and new onset heart failure.",
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AU - Lin, Chin Yu

AU - Chang, Shih Lin

AU - Chung, Fa Po

AU - Chen, Yun Yu

AU - Lin, Yenn Jiang

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Tuan, Ta Chuan

AU - Chao, Tze Fan

AU - Liao, Jo Nan

AU - Chang, Yao Ting

AU - Lin, Chung-Hsing

AU - Allamsetty, Suresh

AU - Walia, Rohit

AU - Te, Abigail Louise D

AU - Yamada, Shinya

AU - Chiang, Shuo Ju

AU - Tsao, Hsuan Ming

AU - Chen, Shih Ann

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N2 - Background: The impact of non-sustained ventricular tachycardia (NSVT) on the risk of thromboembolic event and clinical outcomes in patients without structural heart disease remains undetermined. This study aimed to evaluate the association between NSVT and clinical outcomes. Methods: The study population of 5903 patients was culled from the "Registry of 24-hour ECG monitoring at Taipei Veterans General Hospital" (REMOTE database) between January 1, 2002 and December 31, 2004. Of that total, we enrolled 3767 patients without sustained ventricular tachycardia, structural heart disease, and permanent pacemaker. For purposes of this study, NSVT was defined as 3 or more consecutive beats arising below the atrioventricular node with an RR interval of <600 ms (>100 beats/min) and lasting < 30 seconds. Result: There were 776 deaths, 2042 hospitalizations for any reason, 638 cardiovascular (CV)-related hospitalizations, 350 ischemic strokes, 409 transient ischemic accident (TIA), 368 new-onset heart failure (HF), and 260 new-onset atrial fibrillation (AF) with a mean follow-up duration of 10 ± 1 years. In multivariate analysis, the presence of NSVT was independently associated with death (hazard ratio [HR]: 1.362, 95% confidence interval [CI]: 1.071-1.731), CV hospitalization (HR: 1.527, 95% CI: 1.171-1.992), ischemic stroke (HR: 1.436, 95% CI: 1.014-2.032), TIA (HR 1.483, 95% CI: 1.069-2.057), and new-onset HF (HR: 1.716, 95% CI: 1.243-2.368). There was no significant association between the presence of NSVT and all-cause hospitalization or new-onset AF. Conclusion: In patients without structural heart disease, presence of NSVT on 24-hour monitoring was independently associated with death, CV hospitalization, ischemic stroke, TIA, and new onset heart failure.

AB - Background: The impact of non-sustained ventricular tachycardia (NSVT) on the risk of thromboembolic event and clinical outcomes in patients without structural heart disease remains undetermined. This study aimed to evaluate the association between NSVT and clinical outcomes. Methods: The study population of 5903 patients was culled from the "Registry of 24-hour ECG monitoring at Taipei Veterans General Hospital" (REMOTE database) between January 1, 2002 and December 31, 2004. Of that total, we enrolled 3767 patients without sustained ventricular tachycardia, structural heart disease, and permanent pacemaker. For purposes of this study, NSVT was defined as 3 or more consecutive beats arising below the atrioventricular node with an RR interval of <600 ms (>100 beats/min) and lasting < 30 seconds. Result: There were 776 deaths, 2042 hospitalizations for any reason, 638 cardiovascular (CV)-related hospitalizations, 350 ischemic strokes, 409 transient ischemic accident (TIA), 368 new-onset heart failure (HF), and 260 new-onset atrial fibrillation (AF) with a mean follow-up duration of 10 ± 1 years. In multivariate analysis, the presence of NSVT was independently associated with death (hazard ratio [HR]: 1.362, 95% confidence interval [CI]: 1.071-1.731), CV hospitalization (HR: 1.527, 95% CI: 1.171-1.992), ischemic stroke (HR: 1.436, 95% CI: 1.014-2.032), TIA (HR 1.483, 95% CI: 1.069-2.057), and new-onset HF (HR: 1.716, 95% CI: 1.243-2.368). There was no significant association between the presence of NSVT and all-cause hospitalization or new-onset AF. Conclusion: In patients without structural heart disease, presence of NSVT on 24-hour monitoring was independently associated with death, CV hospitalization, ischemic stroke, TIA, and new onset heart failure.

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