Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: A pooled analysis of individual patient data

Monique Maas, Patty J. Nelemans, Vincenzo Valentini, Prajnan Das, Claus Rödel, Li Jen Kuo, Felipe A. Calvo, Julio García-Aguilar, Rob Glynne-Jones, Karin Haustermans, Mohammed Mohiuddin, Salvatore Pucciarelli, William Small, Javier Suárez, George Theodoropoulos, Sebastiano Biondo, Regina G H Beets-Tan, Geerard L. Beets

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Abstract

Background: Locally advanced rectal cancer is usually treated with preoperative chemoradiation. After chemoradiation and surgery, 15-27% of the patients have no residual viable tumour at pathological examination, a pathological complete response (pCR). This study established whether patients with pCR have better long-term outcome than do those without pCR. Methods: In PubMed, Medline, and Embase we identified 27 articles, based on 17 different datasets, for long-term outcome of patients with and without pCR. 14 investigators agreed to provide individual patient data. All patients underwent chemoradiation and total mesorectal excision. Primary outcome was 5-year disease-free survival. Kaplan-Meier survival functions were computed and hazard ratios (HRs) calculated, with the Cox proportional hazards model. Subgroup analyses were done to test for effect modification by other predicting factors. Interstudy heterogeneity was assessed for disease-free survival and overall survival with forest plots and the Q test. Findings: 484 of 3105 included patients had a pCR. Median follow-up for all patients was 48 months (range 0-277). 5-year crude disease-free survival was 83·3% (95% CI 78·8-87·0) for patients with pCR (61/419 patients had disease recurrence) and 65·6% (63·6-68·0) for those without pCR (747/2263; HR 0·44, 95% CI 0·34-0·57; p

Original languageEnglish
Pages (from-to)835-844
Number of pages10
JournalThe Lancet Oncology
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2010

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Rectal Neoplasms
Disease-Free Survival
Survival
Residual Neoplasm
Proportional Hazards Models
PubMed
Research Personnel
Recurrence

ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

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Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer : A pooled analysis of individual patient data. / Maas, Monique; Nelemans, Patty J.; Valentini, Vincenzo; Das, Prajnan; Rödel, Claus; Kuo, Li Jen; Calvo, Felipe A.; García-Aguilar, Julio; Glynne-Jones, Rob; Haustermans, Karin; Mohiuddin, Mohammed; Pucciarelli, Salvatore; Small, William; Suárez, Javier; Theodoropoulos, George; Biondo, Sebastiano; Beets-Tan, Regina G H; Beets, Geerard L.

In: The Lancet Oncology, Vol. 11, No. 9, 09.2010, p. 835-844.

Research output: Contribution to journalArticle

Maas, M, Nelemans, PJ, Valentini, V, Das, P, Rödel, C, Kuo, LJ, Calvo, FA, García-Aguilar, J, Glynne-Jones, R, Haustermans, K, Mohiuddin, M, Pucciarelli, S, Small, W, Suárez, J, Theodoropoulos, G, Biondo, S, Beets-Tan, RGH & Beets, GL 2010, 'Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: A pooled analysis of individual patient data', The Lancet Oncology, vol. 11, no. 9, pp. 835-844. https://doi.org/10.1016/S1470-2045(10)70172-8
Maas, Monique ; Nelemans, Patty J. ; Valentini, Vincenzo ; Das, Prajnan ; Rödel, Claus ; Kuo, Li Jen ; Calvo, Felipe A. ; García-Aguilar, Julio ; Glynne-Jones, Rob ; Haustermans, Karin ; Mohiuddin, Mohammed ; Pucciarelli, Salvatore ; Small, William ; Suárez, Javier ; Theodoropoulos, George ; Biondo, Sebastiano ; Beets-Tan, Regina G H ; Beets, Geerard L. / Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer : A pooled analysis of individual patient data. In: The Lancet Oncology. 2010 ; Vol. 11, No. 9. pp. 835-844.
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T1 - Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer

T2 - A pooled analysis of individual patient data

AU - Maas, Monique

AU - Nelemans, Patty J.

AU - Valentini, Vincenzo

AU - Das, Prajnan

AU - Rödel, Claus

AU - Kuo, Li Jen

AU - Calvo, Felipe A.

AU - García-Aguilar, Julio

AU - Glynne-Jones, Rob

AU - Haustermans, Karin

AU - Mohiuddin, Mohammed

AU - Pucciarelli, Salvatore

AU - Small, William

AU - Suárez, Javier

AU - Theodoropoulos, George

AU - Biondo, Sebastiano

AU - Beets-Tan, Regina G H

AU - Beets, Geerard L.

PY - 2010/9

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N2 - Background: Locally advanced rectal cancer is usually treated with preoperative chemoradiation. After chemoradiation and surgery, 15-27% of the patients have no residual viable tumour at pathological examination, a pathological complete response (pCR). This study established whether patients with pCR have better long-term outcome than do those without pCR. Methods: In PubMed, Medline, and Embase we identified 27 articles, based on 17 different datasets, for long-term outcome of patients with and without pCR. 14 investigators agreed to provide individual patient data. All patients underwent chemoradiation and total mesorectal excision. Primary outcome was 5-year disease-free survival. Kaplan-Meier survival functions were computed and hazard ratios (HRs) calculated, with the Cox proportional hazards model. Subgroup analyses were done to test for effect modification by other predicting factors. Interstudy heterogeneity was assessed for disease-free survival and overall survival with forest plots and the Q test. Findings: 484 of 3105 included patients had a pCR. Median follow-up for all patients was 48 months (range 0-277). 5-year crude disease-free survival was 83·3% (95% CI 78·8-87·0) for patients with pCR (61/419 patients had disease recurrence) and 65·6% (63·6-68·0) for those without pCR (747/2263; HR 0·44, 95% CI 0·34-0·57; p

AB - Background: Locally advanced rectal cancer is usually treated with preoperative chemoradiation. After chemoradiation and surgery, 15-27% of the patients have no residual viable tumour at pathological examination, a pathological complete response (pCR). This study established whether patients with pCR have better long-term outcome than do those without pCR. Methods: In PubMed, Medline, and Embase we identified 27 articles, based on 17 different datasets, for long-term outcome of patients with and without pCR. 14 investigators agreed to provide individual patient data. All patients underwent chemoradiation and total mesorectal excision. Primary outcome was 5-year disease-free survival. Kaplan-Meier survival functions were computed and hazard ratios (HRs) calculated, with the Cox proportional hazards model. Subgroup analyses were done to test for effect modification by other predicting factors. Interstudy heterogeneity was assessed for disease-free survival and overall survival with forest plots and the Q test. Findings: 484 of 3105 included patients had a pCR. Median follow-up for all patients was 48 months (range 0-277). 5-year crude disease-free survival was 83·3% (95% CI 78·8-87·0) for patients with pCR (61/419 patients had disease recurrence) and 65·6% (63·6-68·0) for those without pCR (747/2263; HR 0·44, 95% CI 0·34-0·57; p

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