Long-term neuroplasticity effects of febrile seizures in the developing brain

Ying Chao Chang, Chao Ching Huang, Song Chei Huang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Febrile seizures (FS) are the most common seizure disorder in childhood, occurring in 2%-5% of children. Regarding the large number of children with FS, it is important to delineate whether early-life FS alters long-term neuroplasticity, especially the neurocognitive function and subsequent temporal lobe epilepsy (TLE). Recent epidemiological studies reassure that most FS do not adversely affect global intelligence and hippocampal function, such as memory. However, there are concerns regarding those children who experience FS during the first postnatal year, having prior developmental delay and pre- or peri-natal events. The epidemiological data do not support a causal relationship between FS and TLE. However, magnetic resonance imaging studies confirmed that prolonged and focal FS can occasionally produce acute hippocampal injury that evolves into atrophy. Moreover, the common coexistence of hippocampal sclerosis and asymmetric cortical dysgenesis in TLE patients argues for a 'double-hit' theory for TLE. Animal studies have revealed that the exposure of hippocampal neurons to FS early in life, particularly prolonged or frequently repetitive FS, or together with brain malformation, may lead to sustained dysfunction of these cells including long-term memory impairment or epileptogenesis, in spite of the absence of neuronal damage. Recent clinical and molecular genetic studies suggest that the relationship between FS and later epilepsy is frequently genetic, and there are a number of syndrome-specific genes for FS. However, these channelopathies account for a small proportion of FS cases. The clinical management, therefore, is based mainly on the phenotypic features of FS and the subsequent seizures.

Original languageEnglish
Pages (from-to)125-135
Number of pages11
JournalChang Gung Medical Journal
Volume31
Issue number2
Publication statusPublished - Mar 2008
Externally publishedYes

Fingerprint

Febrile Seizures
Neuronal Plasticity
Brain
Temporal Lobe Epilepsy
Epilepsy
Seizures
Channelopathies
Long-Term Memory
Sclerosis
Intelligence
Atrophy
Epidemiologic Studies
Molecular Biology

Keywords

  • Febrile seizures
  • Hippocampus
  • Mesial temporal sclerosis
  • Neuroplasticity
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Long-term neuroplasticity effects of febrile seizures in the developing brain. / Chang, Ying Chao; Huang, Chao Ching; Huang, Song Chei.

In: Chang Gung Medical Journal, Vol. 31, No. 2, 03.2008, p. 125-135.

Research output: Contribution to journalArticle

Chang, Ying Chao ; Huang, Chao Ching ; Huang, Song Chei. / Long-term neuroplasticity effects of febrile seizures in the developing brain. In: Chang Gung Medical Journal. 2008 ; Vol. 31, No. 2. pp. 125-135.
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