Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer

Mei Hwei Chang, San Lin You, Chien Jen Chen, Chun Jen Liu, Ming Wei Lai, Tzee Chung Wu, Shu Fen Wu, Chuan Mo Lee, Sheng Shun Yang, Heng Cheng Chu, Tsang Eng Wang, Bor Wen Chen, Wan Long Chuang, Maw Soan Soon, Ching Yih Lin, Shu Ti Chiou, Hsu Sung Kuo, Ding Shinn Chen, Yao Jong Yang, Gin Ho Lo & 16 others Man San Kong, Po Ming Wang, Chi Chieh Yang, Chia Hsiang Chu, Lung Huan Lin, Rong Nan Chien, Tzong Hsi Lee, Kuo Ching Yang, Li Ying Liao, Lein Ray Mo, Jean Dean Liu, Tzeng Huey Yang, Ching Chu Lo, Ming Hung Tsai, Chang Hua Chou, Yeong Shan Cheng

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background & Aims The incidence of hepatocellular carcinoma (HCC) increases with age, but protective antibody responses decrease with time after infants are immunized against hepatitis B virus (HBV). We investigated whether immunization of infants against HBV prevents their developing HCC as adults. We also searched for strategies to maximize the cancer-preventive effects. Methods We collected data from 2 Taiwan HCC registry systems on 1509 patients (6–26 years old) diagnosed with HCC from 1983 through 2011. Data on history of HBV immunization and prenatal maternal levels of HBV antigens of all HCC patients born after July 1984 were retrieved from the HBV immunization data bank of the Taiwan Center for Disease Control. We collected data on birth cohort-specific populations (6–26 years old) of Taiwan using the National Household Registry System. Rates of HCC incidence per 105 person-years were derived by dividing the number of patients with HCC by the person-years of the general population. Relative risks (RR) for HCC were estimated by Poisson regression analysis in vaccinated vs unvaccinated birth cohorts. We stratified patients by age group to evaluate the association of birth cohorts and HCC risks. Results Of the 1509 patients with HCC, 1343 were born before, and 166 were born after, the HBV vaccination program began. HCC incidence per 105 person-years was 0.92 in the unvaccinated cohort and 0.23 in the vaccinated birth cohorts. The RRs for HCC in patients 6–9 years old, 10–14 years old, 15–19 years old, and 20–26 years old who were vaccinated vs unvaccinated were 0.26 (95% confidence interval [CI], 0.17–0.40), 0.34 (95% CI, 0.25–0.48), 0.37 (95% CI, 0.25–0.51), and 0.42 (95% CI, 0.32–0.56), respectively. The RR for HCC in 6- to 26-year-olds was lower in the later vs the earlier cohorts (born in 1992–2005 vs 1986–1992; P <.001 and 1986–1992 vs 1984–1986; P < .002). Transmission of HBV from highly infectious mothers and incomplete immunization were associated with development of HCC. Conclusions Based on an analysis of 1509 patients with HCC in Taiwan, immunization of infants against HBV reduces their risk of developing HCC as children and young adults. Improving HBV vaccination strategies and overcoming risk factors could reduce the incidence of liver cancer.

Original languageEnglish
Pages (from-to)472-480.e1
JournalGastroenterology
Volume151
Issue number3
DOIs
Publication statusPublished - Sep 1 2016
Externally publishedYes

Fingerprint

Liver Neoplasms
Hepatitis B
Hepatocellular Carcinoma
Immunization
Hepatitis B virus
Taiwan
Parturition
Confidence Intervals
Incidence
Registries
Vaccination
Mothers
Hepatitis B Antigens
Centers for Disease Control and Prevention (U.S.)
Population
Antibody Formation
Young Adult

Keywords

  • Cancer Prevention
  • Liver Carcinogenesis
  • Population Study
  • Viral Hepatitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer. / Chang, Mei Hwei; You, San Lin; Chen, Chien Jen; Liu, Chun Jen; Lai, Ming Wei; Wu, Tzee Chung; Wu, Shu Fen; Lee, Chuan Mo; Yang, Sheng Shun; Chu, Heng Cheng; Wang, Tsang Eng; Chen, Bor Wen; Chuang, Wan Long; Soon, Maw Soan; Lin, Ching Yih; Chiou, Shu Ti; Kuo, Hsu Sung; Chen, Ding Shinn; Yang, Yao Jong; Lo, Gin Ho; Kong, Man San; Wang, Po Ming; Yang, Chi Chieh; Chu, Chia Hsiang; Lin, Lung Huan; Chien, Rong Nan; Lee, Tzong Hsi; Yang, Kuo Ching; Liao, Li Ying; Mo, Lein Ray; Liu, Jean Dean; Yang, Tzeng Huey; Lo, Ching Chu; Tsai, Ming Hung; Chou, Chang Hua; Cheng, Yeong Shan.

In: Gastroenterology, Vol. 151, No. 3, 01.09.2016, p. 472-480.e1.

Research output: Contribution to journalArticle

Chang, MH, You, SL, Chen, CJ, Liu, CJ, Lai, MW, Wu, TC, Wu, SF, Lee, CM, Yang, SS, Chu, HC, Wang, TE, Chen, BW, Chuang, WL, Soon, MS, Lin, CY, Chiou, ST, Kuo, HS, Chen, DS, Yang, YJ, Lo, GH, Kong, MS, Wang, PM, Yang, CC, Chu, CH, Lin, LH, Chien, RN, Lee, TH, Yang, KC, Liao, LY, Mo, LR, Liu, JD, Yang, TH, Lo, CC, Tsai, MH, Chou, CH & Cheng, YS 2016, 'Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer', Gastroenterology, vol. 151, no. 3, pp. 472-480.e1. https://doi.org/10.1053/j.gastro.2016.05.048
Chang, Mei Hwei ; You, San Lin ; Chen, Chien Jen ; Liu, Chun Jen ; Lai, Ming Wei ; Wu, Tzee Chung ; Wu, Shu Fen ; Lee, Chuan Mo ; Yang, Sheng Shun ; Chu, Heng Cheng ; Wang, Tsang Eng ; Chen, Bor Wen ; Chuang, Wan Long ; Soon, Maw Soan ; Lin, Ching Yih ; Chiou, Shu Ti ; Kuo, Hsu Sung ; Chen, Ding Shinn ; Yang, Yao Jong ; Lo, Gin Ho ; Kong, Man San ; Wang, Po Ming ; Yang, Chi Chieh ; Chu, Chia Hsiang ; Lin, Lung Huan ; Chien, Rong Nan ; Lee, Tzong Hsi ; Yang, Kuo Ching ; Liao, Li Ying ; Mo, Lein Ray ; Liu, Jean Dean ; Yang, Tzeng Huey ; Lo, Ching Chu ; Tsai, Ming Hung ; Chou, Chang Hua ; Cheng, Yeong Shan. / Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer. In: Gastroenterology. 2016 ; Vol. 151, No. 3. pp. 472-480.e1.
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abstract = "Background & Aims The incidence of hepatocellular carcinoma (HCC) increases with age, but protective antibody responses decrease with time after infants are immunized against hepatitis B virus (HBV). We investigated whether immunization of infants against HBV prevents their developing HCC as adults. We also searched for strategies to maximize the cancer-preventive effects. Methods We collected data from 2 Taiwan HCC registry systems on 1509 patients (6–26 years old) diagnosed with HCC from 1983 through 2011. Data on history of HBV immunization and prenatal maternal levels of HBV antigens of all HCC patients born after July 1984 were retrieved from the HBV immunization data bank of the Taiwan Center for Disease Control. We collected data on birth cohort-specific populations (6–26 years old) of Taiwan using the National Household Registry System. Rates of HCC incidence per 105 person-years were derived by dividing the number of patients with HCC by the person-years of the general population. Relative risks (RR) for HCC were estimated by Poisson regression analysis in vaccinated vs unvaccinated birth cohorts. We stratified patients by age group to evaluate the association of birth cohorts and HCC risks. Results Of the 1509 patients with HCC, 1343 were born before, and 166 were born after, the HBV vaccination program began. HCC incidence per 105 person-years was 0.92 in the unvaccinated cohort and 0.23 in the vaccinated birth cohorts. The RRs for HCC in patients 6–9 years old, 10–14 years old, 15–19 years old, and 20–26 years old who were vaccinated vs unvaccinated were 0.26 (95{\%} confidence interval [CI], 0.17–0.40), 0.34 (95{\%} CI, 0.25–0.48), 0.37 (95{\%} CI, 0.25–0.51), and 0.42 (95{\%} CI, 0.32–0.56), respectively. The RR for HCC in 6- to 26-year-olds was lower in the later vs the earlier cohorts (born in 1992–2005 vs 1986–1992; P <.001 and 1986–1992 vs 1984–1986; P < .002). Transmission of HBV from highly infectious mothers and incomplete immunization were associated with development of HCC. Conclusions Based on an analysis of 1509 patients with HCC in Taiwan, immunization of infants against HBV reduces their risk of developing HCC as children and young adults. Improving HBV vaccination strategies and overcoming risk factors could reduce the incidence of liver cancer.",
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TY - JOUR

T1 - Long-term Effects of Hepatitis B Immunization of Infants in Preventing Liver Cancer

AU - Chang, Mei Hwei

AU - You, San Lin

AU - Chen, Chien Jen

AU - Liu, Chun Jen

AU - Lai, Ming Wei

AU - Wu, Tzee Chung

AU - Wu, Shu Fen

AU - Lee, Chuan Mo

AU - Yang, Sheng Shun

AU - Chu, Heng Cheng

AU - Wang, Tsang Eng

AU - Chen, Bor Wen

AU - Chuang, Wan Long

AU - Soon, Maw Soan

AU - Lin, Ching Yih

AU - Chiou, Shu Ti

AU - Kuo, Hsu Sung

AU - Chen, Ding Shinn

AU - Yang, Yao Jong

AU - Lo, Gin Ho

AU - Kong, Man San

AU - Wang, Po Ming

AU - Yang, Chi Chieh

AU - Chu, Chia Hsiang

AU - Lin, Lung Huan

AU - Chien, Rong Nan

AU - Lee, Tzong Hsi

AU - Yang, Kuo Ching

AU - Liao, Li Ying

AU - Mo, Lein Ray

AU - Liu, Jean Dean

AU - Yang, Tzeng Huey

AU - Lo, Ching Chu

AU - Tsai, Ming Hung

AU - Chou, Chang Hua

AU - Cheng, Yeong Shan

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background & Aims The incidence of hepatocellular carcinoma (HCC) increases with age, but protective antibody responses decrease with time after infants are immunized against hepatitis B virus (HBV). We investigated whether immunization of infants against HBV prevents their developing HCC as adults. We also searched for strategies to maximize the cancer-preventive effects. Methods We collected data from 2 Taiwan HCC registry systems on 1509 patients (6–26 years old) diagnosed with HCC from 1983 through 2011. Data on history of HBV immunization and prenatal maternal levels of HBV antigens of all HCC patients born after July 1984 were retrieved from the HBV immunization data bank of the Taiwan Center for Disease Control. We collected data on birth cohort-specific populations (6–26 years old) of Taiwan using the National Household Registry System. Rates of HCC incidence per 105 person-years were derived by dividing the number of patients with HCC by the person-years of the general population. Relative risks (RR) for HCC were estimated by Poisson regression analysis in vaccinated vs unvaccinated birth cohorts. We stratified patients by age group to evaluate the association of birth cohorts and HCC risks. Results Of the 1509 patients with HCC, 1343 were born before, and 166 were born after, the HBV vaccination program began. HCC incidence per 105 person-years was 0.92 in the unvaccinated cohort and 0.23 in the vaccinated birth cohorts. The RRs for HCC in patients 6–9 years old, 10–14 years old, 15–19 years old, and 20–26 years old who were vaccinated vs unvaccinated were 0.26 (95% confidence interval [CI], 0.17–0.40), 0.34 (95% CI, 0.25–0.48), 0.37 (95% CI, 0.25–0.51), and 0.42 (95% CI, 0.32–0.56), respectively. The RR for HCC in 6- to 26-year-olds was lower in the later vs the earlier cohorts (born in 1992–2005 vs 1986–1992; P <.001 and 1986–1992 vs 1984–1986; P < .002). Transmission of HBV from highly infectious mothers and incomplete immunization were associated with development of HCC. Conclusions Based on an analysis of 1509 patients with HCC in Taiwan, immunization of infants against HBV reduces their risk of developing HCC as children and young adults. Improving HBV vaccination strategies and overcoming risk factors could reduce the incidence of liver cancer.

AB - Background & Aims The incidence of hepatocellular carcinoma (HCC) increases with age, but protective antibody responses decrease with time after infants are immunized against hepatitis B virus (HBV). We investigated whether immunization of infants against HBV prevents their developing HCC as adults. We also searched for strategies to maximize the cancer-preventive effects. Methods We collected data from 2 Taiwan HCC registry systems on 1509 patients (6–26 years old) diagnosed with HCC from 1983 through 2011. Data on history of HBV immunization and prenatal maternal levels of HBV antigens of all HCC patients born after July 1984 were retrieved from the HBV immunization data bank of the Taiwan Center for Disease Control. We collected data on birth cohort-specific populations (6–26 years old) of Taiwan using the National Household Registry System. Rates of HCC incidence per 105 person-years were derived by dividing the number of patients with HCC by the person-years of the general population. Relative risks (RR) for HCC were estimated by Poisson regression analysis in vaccinated vs unvaccinated birth cohorts. We stratified patients by age group to evaluate the association of birth cohorts and HCC risks. Results Of the 1509 patients with HCC, 1343 were born before, and 166 were born after, the HBV vaccination program began. HCC incidence per 105 person-years was 0.92 in the unvaccinated cohort and 0.23 in the vaccinated birth cohorts. The RRs for HCC in patients 6–9 years old, 10–14 years old, 15–19 years old, and 20–26 years old who were vaccinated vs unvaccinated were 0.26 (95% confidence interval [CI], 0.17–0.40), 0.34 (95% CI, 0.25–0.48), 0.37 (95% CI, 0.25–0.51), and 0.42 (95% CI, 0.32–0.56), respectively. The RR for HCC in 6- to 26-year-olds was lower in the later vs the earlier cohorts (born in 1992–2005 vs 1986–1992; P <.001 and 1986–1992 vs 1984–1986; P < .002). Transmission of HBV from highly infectious mothers and incomplete immunization were associated with development of HCC. Conclusions Based on an analysis of 1509 patients with HCC in Taiwan, immunization of infants against HBV reduces their risk of developing HCC as children and young adults. Improving HBV vaccination strategies and overcoming risk factors could reduce the incidence of liver cancer.

KW - Cancer Prevention

KW - Liver Carcinogenesis

KW - Population Study

KW - Viral Hepatitis

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