Long-term arsenic exporure and incidence of non-insulin-dependent diabetes mellitus

A cohort study in arseniasis-hyperendemic villages in Taiwan

Chin Hsiao Tseng, T.-Y. Tai, C. K. Chong, Ching Ping Tseng, Mei Shu Lai, Boniface J. Lin, Hung-Yi Chiou, Yu-Mei Hsueh, Kuang Hung Hsu, Chien Jen Chen

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Abstract

Diabetes prevalence in arseniasis-hyperendemic villages in Taiwan has been reported to be significantly higher than in the general population. The aim of this cohort study was to further evaluate the association between ingested inorganic arsenic and the incidence of non-insulin-dependent diabetes mellitus in these villages. A total of 446 nondiabetic residents in these villages were followed biannually by oral glucose tolerance test. Diabetes is defined as a fasting plasma glucose level ≥7.8 mmol/L and/or a 2-hr post-load glucose level ≥ 11.1 mmol/L. During the follow-up period of 1499.5 person-years, 41 cases developed diabetes, showing an overall incidence of 27.4/1,000 person-years. The incidence of diabetes correlated with age, body mass index, and cumulative arsenic exposure. The multivariate-adjusted relative risks were 1.6, 2.3, and 2.1 for age ≥55 versus <55 years, a body mass index ≥ 25 versus <25 kg/m2, and a cumulative arsenic exposure ≥ 17 versus <17 mg/L-years, respectively. The incidence density ratios (95% confidence intervals) between the hyperendemic villages and the two nonendemic control townships were 3.6 (3.5-3.6), 2.3 (1.1-4.9), 4.3 (2.4-7.7), and 5.5 (2.2-13.5), respectively, for the age groups of 35-44, 45-54, 55-64, and 65-74 years. The findings are consistent with our previous cross-sectional observation that ingested inorganic arsenic is diabetogenic in human beings.

Original languageEnglish
Pages (from-to)847-851
Number of pages5
JournalEnvironmental Health Perspectives
Volume108
Issue number9
Publication statusPublished - 2000

Fingerprint

diabetes
Arsenic
Medical problems
Taiwan
Type 2 Diabetes Mellitus
arsenic
Cohort Studies
village
Incidence
glucose
Body Mass Index
Glucose
body mass
Glucose Tolerance Test
fasting
Fasting
Age Groups
confidence interval
Confidence Intervals
tolerance

Keywords

  • Diabetes mellitus
  • Incidence
  • Ingested arsenic
  • Oral glucose tolerance test
  • Water pollutant

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Tseng, C. H., Tai, T-Y., Chong, C. K., Tseng, C. P., Lai, M. S., Lin, B. J., ... Chen, C. J. (2000). Long-term arsenic exporure and incidence of non-insulin-dependent diabetes mellitus: A cohort study in arseniasis-hyperendemic villages in Taiwan. Environmental Health Perspectives, 108(9), 847-851.

Long-term arsenic exporure and incidence of non-insulin-dependent diabetes mellitus : A cohort study in arseniasis-hyperendemic villages in Taiwan. / Tseng, Chin Hsiao; Tai, T.-Y.; Chong, C. K.; Tseng, Ching Ping; Lai, Mei Shu; Lin, Boniface J.; Chiou, Hung-Yi; Hsueh, Yu-Mei; Hsu, Kuang Hung; Chen, Chien Jen.

In: Environmental Health Perspectives, Vol. 108, No. 9, 2000, p. 847-851.

Research output: Contribution to journalArticle

Tseng, Chin Hsiao ; Tai, T.-Y. ; Chong, C. K. ; Tseng, Ching Ping ; Lai, Mei Shu ; Lin, Boniface J. ; Chiou, Hung-Yi ; Hsueh, Yu-Mei ; Hsu, Kuang Hung ; Chen, Chien Jen. / Long-term arsenic exporure and incidence of non-insulin-dependent diabetes mellitus : A cohort study in arseniasis-hyperendemic villages in Taiwan. In: Environmental Health Perspectives. 2000 ; Vol. 108, No. 9. pp. 847-851.
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