Long GnRH-agonist protocol in an IVF program

Is it appropriate for women with normal FSH levels and high FSH/LH ratios?

Jehn Hsiahn Yang, Ming Yih Wu, Kuang Han Chao, Shee Uan Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

OBJECTIVE: To determine whether subjects with an elevated ratio of follicle-stimulating hormone (FSH) to luteinizing hormone (LH) but normal basal FSH levels should be regarded as poor responders to controlled ovarian hyperstimulation. STUDY DESIGN: One hundred twenty-five women undergoing in vitro fertilization (IVF) for the first time were recruited in this retrospective cohort study. Women over 40 years old or having serum basal FSH > 10 mIU/mL were excluded. RESULTS: Various cutoff values for the FSH/LH ratio were chosen, and the ratio demonstrated that pregnancy rates were apparently higher in patients with the long protocol than with the short one if they had an FSH/LH ratio < 3.0 (48.5% vs. 25.8%, P = .034), < 2.5 (53.3% vs. 28.6%, P = .030) or < 2.0 (57.8% vs. 21.7%, P = .005). Pregnancy rates were similar with the long and short protocols in patients with FSH/LH ≤ 3.0 (57.1% vs. 70%, P = .521), FSH/LH ≤ 2.5 (40% vs. 53.8%, P = .435) or FSH/LH ≤ 2.0 (40% vs. 55.6%, P = .281). CONCLUSION: This study failed to demonstrate that FSH/LH was a useful parameter for predicting reproductive outcome in IVF programs and for patient selection for the long or short gonadotropin-releasing hormone agonist protocol.

Original languageEnglish
Pages (from-to)663-668
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume42
Issue number10
Publication statusPublished - Oct 1 1997
Externally publishedYes

Fingerprint

Buserelin
Ovulation Induction
Embryo Transfer
Follicle Stimulating Hormone
Fertilization in Vitro
Luteinizing Hormone
Gonadotropins
Gonadotropin-Releasing Hormone
Cohort Studies
Retrospective Studies
Pregnancy
Pregnancy Rate
Patient Selection

Keywords

  • Fertilization in vitro
  • FSH
  • Gonadotropins

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Long GnRH-agonist protocol in an IVF program : Is it appropriate for women with normal FSH levels and high FSH/LH ratios? / Yang, Jehn Hsiahn; Wu, Ming Yih; Chao, Kuang Han; Chen, Shee Uan; Ho, Hong Nerng; Yang, Yu Shih.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 42, No. 10, 01.10.1997, p. 663-668.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To determine whether subjects with an elevated ratio of follicle-stimulating hormone (FSH) to luteinizing hormone (LH) but normal basal FSH levels should be regarded as poor responders to controlled ovarian hyperstimulation. STUDY DESIGN: One hundred twenty-five women undergoing in vitro fertilization (IVF) for the first time were recruited in this retrospective cohort study. Women over 40 years old or having serum basal FSH > 10 mIU/mL were excluded. RESULTS: Various cutoff values for the FSH/LH ratio were chosen, and the ratio demonstrated that pregnancy rates were apparently higher in patients with the long protocol than with the short one if they had an FSH/LH ratio < 3.0 (48.5{\%} vs. 25.8{\%}, P = .034), < 2.5 (53.3{\%} vs. 28.6{\%}, P = .030) or < 2.0 (57.8{\%} vs. 21.7{\%}, P = .005). Pregnancy rates were similar with the long and short protocols in patients with FSH/LH ≤ 3.0 (57.1{\%} vs. 70{\%}, P = .521), FSH/LH ≤ 2.5 (40{\%} vs. 53.8{\%}, P = .435) or FSH/LH ≤ 2.0 (40{\%} vs. 55.6{\%}, P = .281). CONCLUSION: This study failed to demonstrate that FSH/LH was a useful parameter for predicting reproductive outcome in IVF programs and for patient selection for the long or short gonadotropin-releasing hormone agonist protocol.",
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