Long driving time is associated with haematological markers of increased cardiovascular risk in taxi drivers

J. C. Chen, Y. J. Chen, W. P. Chang, D. C. Christiani

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Aims: To examine the association between driving time and changes in haematological markers of increased risks for cardiovascular diseases (CVD). Methods: The authors conducted a cross sectional analysis of baseline data from the Taxi Drivers' Health Study cohort in Taipei, Taiwan. They retrieved information on comorbidity, laboratory tests, age, and anthropometric measures from medical records of 1157 subjects (mean age 44.6 (SD 8.6) years). Whole blood cell (WBC) count was used as the primary haematological marker for increased CVD risk, and platelet count and haematocrit as the secondary markers. Standardised questionnaires were implemented to collect information on demographics, lifestyle, work related physical and psychosocial factors, and driving time profiles. Multiple regression was used to estimate the adjusted effects of driving time on three haematological markers. Results: The mean measured hematological marker was 6656 (SD 1656) cells ×106/l for WBC, 47.2 (SD 3.5)% for hematocrit, and 243 (SD 52) cells ×l0 9/l for platelets. The driving time was 264 (SD 76) hours/month. Compared with drivers who drove ≤208 hours/month (1st quartile cut off), drivers who drove >208 hours/month had a higher WBC count (by 317 ×l06/l; 95% CI 99 to 535), haematocrit (by 0.8%; 95% CI 0.3 to 1.2), and platelets (7.9 ×l09/l; 95% CI 1.0 to 14.8). After adjusting for conventional CVD risk factors (age, sex, smoking, hypertension, diabetes, and hypercholesterolaemia), obesity, alcohol drinking, regular exercise, and sociodemographics (education, marital status, income, and so on), long driving time was still associated with significant increases in WBC and platelets, whereas the effect on haematocrit was diminished and became statistically non-significant. Additional controls for physical workload, self-perceived job stress, and job dissatisfaction did not alter the associations with increased WBC and platelets. Conclusions: Longitudinal studies are needed to confirm the observed cross sectional association and to further examine the specific occupational exposures accountable for the association between driving time and haematological markers of systemic inflammation and haemostatic alteration.

Original languageEnglish
Pages (from-to)890-894
Number of pages5
JournalOccupational and Environmental Medicine
Volume62
Issue number12
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

Fingerprint

taxis
Hematocrit
blood
cardiovascular disease
Blood Platelets
Blood Cells
Cardiovascular Diseases
Blood Cell Count
hypertension
obesity
diabetes
Marital Status
occupational exposure
Hemostatics
Occupational Exposure
drinking
Hypercholesterolemia
Workload
smoking
Platelet Count

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Environmental Science(all)

Cite this

Long driving time is associated with haematological markers of increased cardiovascular risk in taxi drivers. / Chen, J. C.; Chen, Y. J.; Chang, W. P.; Christiani, D. C.

In: Occupational and Environmental Medicine, Vol. 62, No. 12, 12.2005, p. 890-894.

Research output: Contribution to journalArticle

@article{76480fdf28684cedbb109447fa7227ae,
title = "Long driving time is associated with haematological markers of increased cardiovascular risk in taxi drivers",
abstract = "Aims: To examine the association between driving time and changes in haematological markers of increased risks for cardiovascular diseases (CVD). Methods: The authors conducted a cross sectional analysis of baseline data from the Taxi Drivers' Health Study cohort in Taipei, Taiwan. They retrieved information on comorbidity, laboratory tests, age, and anthropometric measures from medical records of 1157 subjects (mean age 44.6 (SD 8.6) years). Whole blood cell (WBC) count was used as the primary haematological marker for increased CVD risk, and platelet count and haematocrit as the secondary markers. Standardised questionnaires were implemented to collect information on demographics, lifestyle, work related physical and psychosocial factors, and driving time profiles. Multiple regression was used to estimate the adjusted effects of driving time on three haematological markers. Results: The mean measured hematological marker was 6656 (SD 1656) cells ×106/l for WBC, 47.2 (SD 3.5){\%} for hematocrit, and 243 (SD 52) cells ×l0 9/l for platelets. The driving time was 264 (SD 76) hours/month. Compared with drivers who drove ≤208 hours/month (1st quartile cut off), drivers who drove >208 hours/month had a higher WBC count (by 317 ×l06/l; 95{\%} CI 99 to 535), haematocrit (by 0.8{\%}; 95{\%} CI 0.3 to 1.2), and platelets (7.9 ×l09/l; 95{\%} CI 1.0 to 14.8). After adjusting for conventional CVD risk factors (age, sex, smoking, hypertension, diabetes, and hypercholesterolaemia), obesity, alcohol drinking, regular exercise, and sociodemographics (education, marital status, income, and so on), long driving time was still associated with significant increases in WBC and platelets, whereas the effect on haematocrit was diminished and became statistically non-significant. Additional controls for physical workload, self-perceived job stress, and job dissatisfaction did not alter the associations with increased WBC and platelets. Conclusions: Longitudinal studies are needed to confirm the observed cross sectional association and to further examine the specific occupational exposures accountable for the association between driving time and haematological markers of systemic inflammation and haemostatic alteration.",
author = "Chen, {J. C.} and Chen, {Y. J.} and Chang, {W. P.} and Christiani, {D. C.}",
year = "2005",
month = "12",
doi = "10.1136/oem.2005.020354",
language = "English",
volume = "62",
pages = "890--894",
journal = "Occupational and Environmental Medicine",
issn = "1351-0711",
publisher = "BMJ Publishing Group",
number = "12",

}

TY - JOUR

T1 - Long driving time is associated with haematological markers of increased cardiovascular risk in taxi drivers

AU - Chen, J. C.

AU - Chen, Y. J.

AU - Chang, W. P.

AU - Christiani, D. C.

PY - 2005/12

Y1 - 2005/12

N2 - Aims: To examine the association between driving time and changes in haematological markers of increased risks for cardiovascular diseases (CVD). Methods: The authors conducted a cross sectional analysis of baseline data from the Taxi Drivers' Health Study cohort in Taipei, Taiwan. They retrieved information on comorbidity, laboratory tests, age, and anthropometric measures from medical records of 1157 subjects (mean age 44.6 (SD 8.6) years). Whole blood cell (WBC) count was used as the primary haematological marker for increased CVD risk, and platelet count and haematocrit as the secondary markers. Standardised questionnaires were implemented to collect information on demographics, lifestyle, work related physical and psychosocial factors, and driving time profiles. Multiple regression was used to estimate the adjusted effects of driving time on three haematological markers. Results: The mean measured hematological marker was 6656 (SD 1656) cells ×106/l for WBC, 47.2 (SD 3.5)% for hematocrit, and 243 (SD 52) cells ×l0 9/l for platelets. The driving time was 264 (SD 76) hours/month. Compared with drivers who drove ≤208 hours/month (1st quartile cut off), drivers who drove >208 hours/month had a higher WBC count (by 317 ×l06/l; 95% CI 99 to 535), haematocrit (by 0.8%; 95% CI 0.3 to 1.2), and platelets (7.9 ×l09/l; 95% CI 1.0 to 14.8). After adjusting for conventional CVD risk factors (age, sex, smoking, hypertension, diabetes, and hypercholesterolaemia), obesity, alcohol drinking, regular exercise, and sociodemographics (education, marital status, income, and so on), long driving time was still associated with significant increases in WBC and platelets, whereas the effect on haematocrit was diminished and became statistically non-significant. Additional controls for physical workload, self-perceived job stress, and job dissatisfaction did not alter the associations with increased WBC and platelets. Conclusions: Longitudinal studies are needed to confirm the observed cross sectional association and to further examine the specific occupational exposures accountable for the association between driving time and haematological markers of systemic inflammation and haemostatic alteration.

AB - Aims: To examine the association between driving time and changes in haematological markers of increased risks for cardiovascular diseases (CVD). Methods: The authors conducted a cross sectional analysis of baseline data from the Taxi Drivers' Health Study cohort in Taipei, Taiwan. They retrieved information on comorbidity, laboratory tests, age, and anthropometric measures from medical records of 1157 subjects (mean age 44.6 (SD 8.6) years). Whole blood cell (WBC) count was used as the primary haematological marker for increased CVD risk, and platelet count and haematocrit as the secondary markers. Standardised questionnaires were implemented to collect information on demographics, lifestyle, work related physical and psychosocial factors, and driving time profiles. Multiple regression was used to estimate the adjusted effects of driving time on three haematological markers. Results: The mean measured hematological marker was 6656 (SD 1656) cells ×106/l for WBC, 47.2 (SD 3.5)% for hematocrit, and 243 (SD 52) cells ×l0 9/l for platelets. The driving time was 264 (SD 76) hours/month. Compared with drivers who drove ≤208 hours/month (1st quartile cut off), drivers who drove >208 hours/month had a higher WBC count (by 317 ×l06/l; 95% CI 99 to 535), haematocrit (by 0.8%; 95% CI 0.3 to 1.2), and platelets (7.9 ×l09/l; 95% CI 1.0 to 14.8). After adjusting for conventional CVD risk factors (age, sex, smoking, hypertension, diabetes, and hypercholesterolaemia), obesity, alcohol drinking, regular exercise, and sociodemographics (education, marital status, income, and so on), long driving time was still associated with significant increases in WBC and platelets, whereas the effect on haematocrit was diminished and became statistically non-significant. Additional controls for physical workload, self-perceived job stress, and job dissatisfaction did not alter the associations with increased WBC and platelets. Conclusions: Longitudinal studies are needed to confirm the observed cross sectional association and to further examine the specific occupational exposures accountable for the association between driving time and haematological markers of systemic inflammation and haemostatic alteration.

UR - http://www.scopus.com/inward/record.url?scp=28444468159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28444468159&partnerID=8YFLogxK

U2 - 10.1136/oem.2005.020354

DO - 10.1136/oem.2005.020354

M3 - Article

VL - 62

SP - 890

EP - 894

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 12

ER -