Objectives: To compare the therapeutic effects of locoregional deep hyperthermia combined with intravesical chemotherapy with those of intravesical chemotherapy alone in patients with intermediate-/high-risk non-muscle invasive bladder cancer (NMIBC). To evaluate the impact of thermal dose in hyperthermia treatment. Methods: We analyzed data retrieved from the medical records of patients with intermediate-/high-risk NMIBC treated with intravesical mitomycin (IM group) or locoregional deep hyperthermia combined with intravesical mitomycin (CHT group) at a single tertiary care hospital between May 2016 and June 2019. The primary and secondary endpoints were the recurrence-free survival rate and progression-free survival rate, respectively. Thermal dose was evaluated and adverse events were also recorded. Results: In total, 43 patients (CHT: 18 patients, IM: 25 patients) were enrolled. The median follow-up durations were 14 and 23 months, respectively. The recurrence rate at 12 months was significantly lower in the CHT group than in the IM group (11.1% vs. 44%, p =.048); this trend persisted at 24 months (CHT: 11.1%, IM: 48%; p =.027). The recurrence-free survival was also significantly higher in the CHT group than in the IM group (p =.028). No tumor recurrence was noted in patients who received a thermal dose of ≥4 CEM43. All adverse events were well tolerated, and there was no treatment-related mortality. Conclusions: Intravesical chemotherapy combined with locoregional deep hyperthermia for intermediate-/high-risk papillary NMIBC can significantly decrease the recurrence rate relative to that observed after intravesical chemotherapy alone.
|Number of pages||6|
|Journal||International Journal of Hyperthermia|
|Publication status||Published - 2021|
- bladder cancer
- thermal dose
ASJC Scopus subject areas
- Physiology (medical)
- Cancer Research
FingerprintDive into the research topics of 'Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer'. Together they form a unique fingerprint.
Loco-regional deep hyperthermia combined with intravesical Mitomycin instillation reduces the recurrence of non-muscle invasive papillary bladder cancer
Wen, Y. (Creator), Lee, L. (Creator), Lin, Y. (Creator), Syu, S. (Creator), Lin, K. (Creator), Fan, Y. (Creator), Lee, H. (Creator), Lai, B. C. H. (Creator) & Shih, H. (Creator), Taylor & Francis, 2021
DOI: 10.6084/m9.figshare.17009635.v1, https://tandf.figshare.com/articles/journal_contribution/Loco-regional_deep_hyperthermia_combined_with_intravesical_Mitomycin_instillation_reduces_the_recurrence_of_non-muscle_invasive_papillary_bladder_cancer/17009635/1