Local massage after vaccination enhances the immunogenicity of diphtheria-tetanus-pertussis vaccine

Ching Ying Hsu, Li Min Huang, Chin Yun Lee, Tzou Yien Lin, Ping Ing Lee, Jong Min Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of local massage on adverse reactions and immunogenicity of diphtheria-tetanus-pertussis vaccine was investigated. After diphtheria-tetanus-pertussis vaccination 327 infants were either massaged or not, and adverse reactions were evaluated. Local pain and fever were more frequent in the massage group. The extra febrile episodes from massage were mild (38–39°C). For evaluation of the antibody responses, 124 infants were recruited into massage or nonmassage cohorts and antibody production was measured at 2, 6, 7, 18 and 19 months of age, respectively. Subjects in the massage group developed significantly higher antibodies against filamentous hemagglutinin at 6 and 7 months of age, pertussis toxin at 6, 7, 18 and 19 months of age, pertussis agglutinogen at 18 and 19 months of age and diphtheria toxoid at 6 and 7 months of age than those in the nonmassage group. Local massage after diphtheria-tetanus-pertussis vaccination was associated with better immunogenicity and more adverse reactions, including low grade fever and local pain, which were mild and not particularly disturbing.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalPediatric Infectious Disease Journal
Volume14
Issue number7
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • Adverse reactions
  • Diphtheria-tetanus-pertussis
  • Immunogenicity
  • Local massage

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health

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