Local intra-arterial thrombolytic therapy for patients with acute ischemic stroke

Chun Chieh Lin, Kwo Whei Lee, Chao Giieh Chang, Che Hung Yen, Yaw Don Hsu, Jiann Chyun Lin, Guann Juh Chen, Shy Chi Chin, Cheng Yu Chen, Giia Sheun Peng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Acute thrombolysis for ischemic stroke has been proposed to help some suitable patients. We investigated the application of local intra-arterial thrombolytic therapy to patients with ischemic stroke in different territories of vascular occlusion. Methods: Ten patients with ischemic stroke, five with middle cerebral artery (MCA) occlusion, three with internal carotid artery (ICA) occlusion, and two with basilar artery (BA) occlusion, were treated by local intra-arterial infusion of urokinase. The end-point was at either reaching the maximal dosage of 1.5 MIU urokinase, early recanalization or suspicion of the occurrence of complications. Stroke scales were used to evaluate their clinical outcomes at the onset, and 7, 30 and 90 days after treatment. Results: The mean age was 59.4±12.2 (range 37 to 73) years; median baseline NIH Stroke Scale was 18.5 ±6.8 (range 8 to 30). Four of five patients with MCA occlusion had good recanalization and one had incomplete recanalization. Two patients with BA occlusion showed good recanalization and improvement of neurological deficits. In contrast, all the patients with ICA occlusion did not show recanalization and the clinical outcomes were poor. Four patients (three with MCA occlusion and one with BA occlusion) had favorable outcomes. Three patients had mild to moderate intracranial hemorrhage. Two patients died of acute myocardial infarction and symptomatic cerebral mass effect with tentorial herniation. Conclusions: Our results showed that local intra-arterial thrombolysis to treat some acute ischemic stroke due to MCA or BA occlusion might have fewer complications and better outcome than those with ICA occlusion.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalActa Neurologica Taiwanica
Volume12
Issue number1
Publication statusPublished - Mar 2003
Externally publishedYes

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Thrombolytic Therapy
Stroke
Basilar Artery
Middle Cerebral Artery Infarction
Internal Carotid Artery
Urokinase-Type Plasminogen Activator
Intra Arterial Infusions
Intracranial Hemorrhages
Middle Cerebral Artery
Blood Vessels
Myocardial Infarction

Keywords

  • Stroke
  • Thrombolysis
  • Urokinase

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Lin, C. C., Lee, K. W., Chang, C. G., Yen, C. H., Hsu, Y. D., Lin, J. C., ... Peng, G. S. (2003). Local intra-arterial thrombolytic therapy for patients with acute ischemic stroke. Acta Neurologica Taiwanica, 12(1), 7-14.

Local intra-arterial thrombolytic therapy for patients with acute ischemic stroke. / Lin, Chun Chieh; Lee, Kwo Whei; Chang, Chao Giieh; Yen, Che Hung; Hsu, Yaw Don; Lin, Jiann Chyun; Chen, Guann Juh; Chin, Shy Chi; Chen, Cheng Yu; Peng, Giia Sheun.

In: Acta Neurologica Taiwanica, Vol. 12, No. 1, 03.2003, p. 7-14.

Research output: Contribution to journalArticle

Lin, CC, Lee, KW, Chang, CG, Yen, CH, Hsu, YD, Lin, JC, Chen, GJ, Chin, SC, Chen, CY & Peng, GS 2003, 'Local intra-arterial thrombolytic therapy for patients with acute ischemic stroke', Acta Neurologica Taiwanica, vol. 12, no. 1, pp. 7-14.
Lin CC, Lee KW, Chang CG, Yen CH, Hsu YD, Lin JC et al. Local intra-arterial thrombolytic therapy for patients with acute ischemic stroke. Acta Neurologica Taiwanica. 2003 Mar;12(1):7-14.
Lin, Chun Chieh ; Lee, Kwo Whei ; Chang, Chao Giieh ; Yen, Che Hung ; Hsu, Yaw Don ; Lin, Jiann Chyun ; Chen, Guann Juh ; Chin, Shy Chi ; Chen, Cheng Yu ; Peng, Giia Sheun. / Local intra-arterial thrombolytic therapy for patients with acute ischemic stroke. In: Acta Neurologica Taiwanica. 2003 ; Vol. 12, No. 1. pp. 7-14.
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