Local awakening: Regional reorganizations of brain oscillations after sleep

Pei Jung Tsai, Sharon Chia Ju Chen, Chun Yao Hsu, Chang-Wei Wu, Yu Chin Wu, Ching Sui Hung, Albert C. Yang, Po Yu Liu, Bharat Biswal, Ching Po Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Brain functions express rhythmic fluctuations accompanied by sleep and wakefulness each day, but how sleep regulates brain rhythms remains unclear. Following the dose-dependent local sleep concept, two succeeding questions emerge: (1) is the sleep regulation a network-specific process; and (2) is the awakening state dependent on the previous sleep stages? To answer the questions, we conducted simultaneous EEG and fMRI recordings over 22 healthy male participants, along pre-sleep, nocturnal sleep and awakening. Using paired comparisons between awakening and pre-sleep conditions, three scenarios of the regional specificity were demonstrated on awakening: (1) the default-mode and hippocampal networks maintained similar connectivity and spectral power; (2) the sensorimotor network presented reduced connectivity and spectral power; and (3) the thalamus demonstrated substantially enhanced connectivity to the neo-cortex with decreased spectral power. With regard to the stage effect, the deep sleep group had significant changes in both functional connectivity and spectral power on awakening, whereas the indices of light sleep group remained relatively quiescent after sleep. The phenomena implied that slow-wave sleep could be key to rebooting the BOLD fluctuations after sleep. In conclusion, the regional specificity and the stage effect were verified in support of the local awakening concept, indicating that sleep regulation leads to the reorganization of brain networks upon awakening.

Original languageEnglish
Pages (from-to)894-903
Number of pages10
JournalNeuroImage
Volume102
Issue numberP2
DOIs
Publication statusPublished - Nov 5 2014
Externally publishedYes

Fingerprint

Sleep
Brain
Matched-Pair Analysis
Wakefulness
Sleep Stages
Thalamus
Electroencephalography
Healthy Volunteers
Magnetic Resonance Imaging
Light
Power (Psychology)

Keywords

  • Functional connectivity
  • Local awakening
  • Local sleep
  • Simultaneous EEG-fMRI recordings
  • Spectral power
  • Thalamo-cortical connectivity

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology
  • Medicine(all)

Cite this

Tsai, P. J., Chen, S. C. J., Hsu, C. Y., Wu, C-W., Wu, Y. C., Hung, C. S., ... Lin, C. P. (2014). Local awakening: Regional reorganizations of brain oscillations after sleep. NeuroImage, 102(P2), 894-903. https://doi.org/10.1016/j.neuroimage.2014.07.032

Local awakening : Regional reorganizations of brain oscillations after sleep. / Tsai, Pei Jung; Chen, Sharon Chia Ju; Hsu, Chun Yao; Wu, Chang-Wei; Wu, Yu Chin; Hung, Ching Sui; Yang, Albert C.; Liu, Po Yu; Biswal, Bharat; Lin, Ching Po.

In: NeuroImage, Vol. 102, No. P2, 05.11.2014, p. 894-903.

Research output: Contribution to journalArticle

Tsai, PJ, Chen, SCJ, Hsu, CY, Wu, C-W, Wu, YC, Hung, CS, Yang, AC, Liu, PY, Biswal, B & Lin, CP 2014, 'Local awakening: Regional reorganizations of brain oscillations after sleep', NeuroImage, vol. 102, no. P2, pp. 894-903. https://doi.org/10.1016/j.neuroimage.2014.07.032
Tsai, Pei Jung ; Chen, Sharon Chia Ju ; Hsu, Chun Yao ; Wu, Chang-Wei ; Wu, Yu Chin ; Hung, Ching Sui ; Yang, Albert C. ; Liu, Po Yu ; Biswal, Bharat ; Lin, Ching Po. / Local awakening : Regional reorganizations of brain oscillations after sleep. In: NeuroImage. 2014 ; Vol. 102, No. P2. pp. 894-903.
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