LMX1A as a prognostic marker in ovarian mucinous cystadenocarcinoma

Chih Kung Lin, Tai Kuang Chao, Hung Cheng Lai, Herng Sheng Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This study aimed to evaluate the relationship of LMX1A and osteopontin (OPN) expression with clinicopathologic parameters for the 4 most common ovarian surface epithelial carcinomas. Both biomarkers were investigated immunohistochemically using tissue microarrays of 249 specimens including 91 serous cystadenocarcinomas, 56 mucinous cystadenocarcinomas, 64 endometrioid adenocarcinomas, 26 clear cell carcinomas, and 12 normal ovarian tissues. All 4 carcinomas showed significant expression of LMX1A and OPN. In addition, higher immunostaining scores and percentage of cells stained for LMX1A in mucinous cystadenocarcinomas correlated with T stage, American Joint Committee on Cancer clinical stage, poorer tumor differentiation, and poorer survival rate. In serous cystadenocarcinoma, higher percentage of staining for OPN and higher intensity or immunostaining scores for LMX1A correlated with poorer tumor differentiation. Thus, the expression of LMX1A may be an independent prognostic risk factor in mucinous cystadenocarcinoma and a helpful marker in evaluating this tumor's aggressiveness.

Original languageEnglish
Pages (from-to)971-977
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume137
Issue number6
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

Keywords

  • Immunostaining score
  • LMX1A
  • Osteopontin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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