Liposomes incorporated with cholesterol for drug release triggered by magnetic field

Li Ping Tseng, Hong Jen Liang, Tze Wen Chung, Yi You Huang, Der Zen Liu

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Liposome formulated with cholesterol at different ratios was used to investigate the extent of drug release triggered by magnetic forces. Liposomes were prepared at various ratios of DPPC/cholesterol (4:0, 4:0.5, 4:1, 4:2, at 5 mM lipid concentration), and encapsulated 5(6)-Carboxylfluorescein [5(6)-CF] by the method of thin film hydration. They were then characterized by differential scanning calorimetry (DSC) and deformability experiments to investigate the relationship between physical stability and the addition of cholesterol. The influence of magnetic field on the release of encapsulated drug was also investigated. The results showed that deformability of liposomes decreased in terms of an increase in liposomal stability with increasing cholesterol incorporation. The zeta potential and particle sizes for liposomes under different strengths magnetic field changed dramatically, suggesting that the magnetic orientation of the lipid molecules caused changes in zeta potential and particle size. Liposome of DPPC/cholesterol=4:1 exhibited the highest physical stability and showed a 66% difference in drug release over the absence of a magnetic field. Liposome of DPPC/cholesterol=4:1 seems to be the optimal liposome formulation for drug release under a magnetic field.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Medical and Biological Engineering
Volume27
Issue number1
Publication statusPublished - Mar 2007

Fingerprint

Liposomes
Cholesterol
Magnetic Fields
Magnetic fields
Zeta potential
Formability
Particle Size
Lipids
Particle size
Differential Scanning Calorimetry
Drug Liberation
Hydration
Differential scanning calorimetry
Thin films
Molecules

Keywords

  • Liposome
  • Magnetic field
  • Trigger release

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)
  • Biotechnology

Cite this

Liposomes incorporated with cholesterol for drug release triggered by magnetic field. / Tseng, Li Ping; Liang, Hong Jen; Chung, Tze Wen; Huang, Yi You; Liu, Der Zen.

In: Journal of Medical and Biological Engineering, Vol. 27, No. 1, 03.2007, p. 29-34.

Research output: Contribution to journalArticle

Tseng, Li Ping ; Liang, Hong Jen ; Chung, Tze Wen ; Huang, Yi You ; Liu, Der Zen. / Liposomes incorporated with cholesterol for drug release triggered by magnetic field. In: Journal of Medical and Biological Engineering. 2007 ; Vol. 27, No. 1. pp. 29-34.
@article{0349fcba5db14a3a997cca3cac91f85a,
title = "Liposomes incorporated with cholesterol for drug release triggered by magnetic field",
abstract = "Liposome formulated with cholesterol at different ratios was used to investigate the extent of drug release triggered by magnetic forces. Liposomes were prepared at various ratios of DPPC/cholesterol (4:0, 4:0.5, 4:1, 4:2, at 5 mM lipid concentration), and encapsulated 5(6)-Carboxylfluorescein [5(6)-CF] by the method of thin film hydration. They were then characterized by differential scanning calorimetry (DSC) and deformability experiments to investigate the relationship between physical stability and the addition of cholesterol. The influence of magnetic field on the release of encapsulated drug was also investigated. The results showed that deformability of liposomes decreased in terms of an increase in liposomal stability with increasing cholesterol incorporation. The zeta potential and particle sizes for liposomes under different strengths magnetic field changed dramatically, suggesting that the magnetic orientation of the lipid molecules caused changes in zeta potential and particle size. Liposome of DPPC/cholesterol=4:1 exhibited the highest physical stability and showed a 66{\%} difference in drug release over the absence of a magnetic field. Liposome of DPPC/cholesterol=4:1 seems to be the optimal liposome formulation for drug release under a magnetic field.",
keywords = "Liposome, Magnetic field, Trigger release",
author = "Tseng, {Li Ping} and Liang, {Hong Jen} and Chung, {Tze Wen} and Huang, {Yi You} and Liu, {Der Zen}",
year = "2007",
month = "3",
language = "English",
volume = "27",
pages = "29--34",
journal = "Journal of Medical and Biological Engineering",
issn = "1609-0985",
publisher = "中華民國生物醫學工程學會",
number = "1",

}

TY - JOUR

T1 - Liposomes incorporated with cholesterol for drug release triggered by magnetic field

AU - Tseng, Li Ping

AU - Liang, Hong Jen

AU - Chung, Tze Wen

AU - Huang, Yi You

AU - Liu, Der Zen

PY - 2007/3

Y1 - 2007/3

N2 - Liposome formulated with cholesterol at different ratios was used to investigate the extent of drug release triggered by magnetic forces. Liposomes were prepared at various ratios of DPPC/cholesterol (4:0, 4:0.5, 4:1, 4:2, at 5 mM lipid concentration), and encapsulated 5(6)-Carboxylfluorescein [5(6)-CF] by the method of thin film hydration. They were then characterized by differential scanning calorimetry (DSC) and deformability experiments to investigate the relationship between physical stability and the addition of cholesterol. The influence of magnetic field on the release of encapsulated drug was also investigated. The results showed that deformability of liposomes decreased in terms of an increase in liposomal stability with increasing cholesterol incorporation. The zeta potential and particle sizes for liposomes under different strengths magnetic field changed dramatically, suggesting that the magnetic orientation of the lipid molecules caused changes in zeta potential and particle size. Liposome of DPPC/cholesterol=4:1 exhibited the highest physical stability and showed a 66% difference in drug release over the absence of a magnetic field. Liposome of DPPC/cholesterol=4:1 seems to be the optimal liposome formulation for drug release under a magnetic field.

AB - Liposome formulated with cholesterol at different ratios was used to investigate the extent of drug release triggered by magnetic forces. Liposomes were prepared at various ratios of DPPC/cholesterol (4:0, 4:0.5, 4:1, 4:2, at 5 mM lipid concentration), and encapsulated 5(6)-Carboxylfluorescein [5(6)-CF] by the method of thin film hydration. They were then characterized by differential scanning calorimetry (DSC) and deformability experiments to investigate the relationship between physical stability and the addition of cholesterol. The influence of magnetic field on the release of encapsulated drug was also investigated. The results showed that deformability of liposomes decreased in terms of an increase in liposomal stability with increasing cholesterol incorporation. The zeta potential and particle sizes for liposomes under different strengths magnetic field changed dramatically, suggesting that the magnetic orientation of the lipid molecules caused changes in zeta potential and particle size. Liposome of DPPC/cholesterol=4:1 exhibited the highest physical stability and showed a 66% difference in drug release over the absence of a magnetic field. Liposome of DPPC/cholesterol=4:1 seems to be the optimal liposome formulation for drug release under a magnetic field.

KW - Liposome

KW - Magnetic field

KW - Trigger release

UR - http://www.scopus.com/inward/record.url?scp=34248182614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248182614&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 29

EP - 34

JO - Journal of Medical and Biological Engineering

JF - Journal of Medical and Biological Engineering

SN - 1609-0985

IS - 1

ER -