Lipid metabolism in hypercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non-dialyzed soybean protein fraction

Jiun Rong Chen, Shiau Fang Chiou, Kunio Suetsuna, Hsin Yi Yang, Suh Ching Yang

Research output: Contribution to journalArticle

17 Citations (Scopus)


OBJECTIVE: We investigated lipid metabolism in hypercholesterolemic rats after replacing casein with different amounts of undialyzed soybean protein fraction. METHODS: The hypercholesterolemic rats were fed cholesterol-free diets containing 2%, 5%, or 10% undialyzed soybean protein fraction (UDSP) for 4 wk. RESULTS: The 5% and 10% UDSP groups had significantly lower plasma cholesterol, triacylglycerol, and low-density lipoprotein cholesterol concentrations than did the other groups (P <0.05). In addition, significantly higher fecal total steroid excretion was observed in these two groups. However, the different amounts of UDSP did not influence liver lipid, plasma high-density lipoprotein cholesterol, body weight gain, daily food intake, or feeding efficiency. CONCLUSION: These results suggested a dose-dependent reduction in plasma cholesterol when casein was replaced stepwise with UDSP (5% or 10%) as a protein source. The hypocholesterolemic effect might have been due to an increase in total fecal steroid excretion.

Original languageEnglish
Pages (from-to)676-680
Number of pages5
Issue number7-8
Publication statusPublished - Jul 2003



  • Casein
  • Cholesterol
  • Hydrolysate
  • Hypercholesterolemia
  • Lipid metabolism
  • Rat
  • Rats
  • Soybean protein
  • Undialyzed soybean protein fraction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Medicine (miscellaneous)

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