Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling

Karin C S Chen Liu, Shoei Sheng Lee, Mei Tsu Lin, Chia Wen Chang, Chao Lin Liu, Jung Yaw Lin, Feng Lin Hsu, Shijun Ren, Eric J. Lien

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The inhibitory activities against HIV-1 RT and hDNAP-α of 15 lignans and tannins isolated from Chinese herbs have been correlated with physicochemical parameters (μ, log MW, Hb, I). From the overall shapes of 3-D structures, a T-shaped perpendicular ring system gives the best differential inhibition against HIV-1 RT, while a more complicated π-shaped ring system is associated with high inhibition against both HIV-1 RT and hDNAP-α. These findings indicate that there are different structural requirements for the inhibition of each of the target enzyme.

Original languageEnglish
Pages (from-to)168-179
Number of pages12
JournalMedicinal Chemistry Research
Volume7
Issue number3
Publication statusPublished - 1997

Fingerprint

Lignans
Reverse Transcriptase Inhibitors
Molecular modeling
Tannins
RNA-Directed DNA Polymerase
DNA-Directed DNA Polymerase
HIV-1
Enzymes

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery

Cite this

Chen Liu, K. C. S., Lee, S. S., Lin, M. T., Chang, C. W., Liu, C. L., Lin, J. Y., ... Lien, E. J. (1997). Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling. Medicinal Chemistry Research, 7(3), 168-179.

Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α : Qsar analysis and molecular modeling. / Chen Liu, Karin C S; Lee, Shoei Sheng; Lin, Mei Tsu; Chang, Chia Wen; Liu, Chao Lin; Lin, Jung Yaw; Hsu, Feng Lin; Ren, Shijun; Lien, Eric J.

In: Medicinal Chemistry Research, Vol. 7, No. 3, 1997, p. 168-179.

Research output: Contribution to journalArticle

Chen Liu, KCS, Lee, SS, Lin, MT, Chang, CW, Liu, CL, Lin, JY, Hsu, FL, Ren, S & Lien, EJ 1997, 'Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling', Medicinal Chemistry Research, vol. 7, no. 3, pp. 168-179.
Chen Liu, Karin C S ; Lee, Shoei Sheng ; Lin, Mei Tsu ; Chang, Chia Wen ; Liu, Chao Lin ; Lin, Jung Yaw ; Hsu, Feng Lin ; Ren, Shijun ; Lien, Eric J. / Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α : Qsar analysis and molecular modeling. In: Medicinal Chemistry Research. 1997 ; Vol. 7, No. 3. pp. 168-179.
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