The inhibitory activities against HIV-1 RT and hDNAP-α of 15 lignans and tannins isolated from Chinese herbs have been correlated with physicochemical parameters (μ, log MW, Hb, I). From the overall shapes of 3-D structures, a T-shaped perpendicular ring system gives the best differential inhibition against HIV-1 RT, while a more complicated π-shaped ring system is associated with high inhibition against both HIV-1 RT and hDNAP-α. These findings indicate that there are different structural requirements for the inhibition of each of the target enzyme.
|Number of pages||12|
|Journal||Medicinal Chemistry Research|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery