Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling

Karin C S Chen Liu; Shoei Sheng Lee; Mei Tsu Lin; Chia Wen Chang; Chao Lin Liu; Jung Yaw Lin; Feng Lin Hsu; Shijun Ren; Eric J. Lien

Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling

Karin C S Chen Liu, Shoei Sheng Lee, Mei Tsu Lin, Chia Wen Chang, Chao Lin Liu, Jung Yaw Lin, Feng Lin Hsu, Shijun Ren, Eric J. Lien

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The inhibitory activities against HIV-1 RT and hDNAP-α of 15 lignans and tannins isolated from Chinese herbs have been correlated with physicochemical parameters (μ, log MW, Hb, I). From the overall shapes of 3-D structures, a T-shaped perpendicular ring system gives the best differential inhibition against HIV-1 RT, while a more complicated π-shaped ring system is associated with high inhibition against both HIV-1 RT and hDNAP-α. These findings indicate that there are different structural requirements for the inhibition of each of the target enzyme.

Original language	English
Pages (from-to)	168-179
Number of pages	12
Journal	Medicinal Chemistry Research
Volume	7
Issue number	3
Publication status	Published - 1997

ASJC Scopus subject areas

Organic Chemistry
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling",

abstract = "The inhibitory activities against HIV-1 RT and hDNAP-α of 15 lignans and tannins isolated from Chinese herbs have been correlated with physicochemical parameters (μ, log MW, Hb, I). From the overall shapes of 3-D structures, a T-shaped perpendicular ring system gives the best differential inhibition against HIV-1 RT, while a more complicated π-shaped ring system is associated with high inhibition against both HIV-1 RT and hDNAP-α. These findings indicate that there are different structural requirements for the inhibition of each of the target enzyme.",

author = "{Chen Liu}, {Karin C S} and Lee, {Shoei Sheng} and Lin, {Mei Tsu} and Chang, {Chia Wen} and Liu, {Chao Lin} and Lin, {Jung Yaw} and Hsu, {Feng Lin} and Shijun Ren and Lien, {Eric J.}",

year = "1997",

language = "English",

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pages = "168--179",

journal = "Medicinal Chemistry Research",

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TY - JOUR

T1 - Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α

T2 - Qsar analysis and molecular modeling

AU - Chen Liu, Karin C S

AU - Lee, Shoei Sheng

AU - Lin, Mei Tsu

AU - Chang, Chia Wen

AU - Liu, Chao Lin

AU - Lin, Jung Yaw

AU - Hsu, Feng Lin

AU - Ren, Shijun

AU - Lien, Eric J.

PY - 1997

Y1 - 1997

N2 - The inhibitory activities against HIV-1 RT and hDNAP-α of 15 lignans and tannins isolated from Chinese herbs have been correlated with physicochemical parameters (μ, log MW, Hb, I). From the overall shapes of 3-D structures, a T-shaped perpendicular ring system gives the best differential inhibition against HIV-1 RT, while a more complicated π-shaped ring system is associated with high inhibition against both HIV-1 RT and hDNAP-α. These findings indicate that there are different structural requirements for the inhibition of each of the target enzyme.

AB - The inhibitory activities against HIV-1 RT and hDNAP-α of 15 lignans and tannins isolated from Chinese herbs have been correlated with physicochemical parameters (μ, log MW, Hb, I). From the overall shapes of 3-D structures, a T-shaped perpendicular ring system gives the best differential inhibition against HIV-1 RT, while a more complicated π-shaped ring system is associated with high inhibition against both HIV-1 RT and hDNAP-α. These findings indicate that there are different structural requirements for the inhibition of each of the target enzyme.

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M3 - Article

AN - SCOPUS:0001501234

SN - 1054-2523

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SP - 168

EP - 179

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 3

ER -

Lignans and tannins as inhibitors of viral reverse transcriptase and human DNA polymerase-α: Qsar analysis and molecular modeling

Abstract

ASJC Scopus subject areas

UN SDGs

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