Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus

Shu Chen Wang, Chia Hui Lin, Tsan Teng Ou, Cheng Chin Wu, Wen Chan Tsai, Chaur Jong Hu, Hong Wen Liu, Jeng Hsien Yen

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18 Citations (Scopus)

Abstract

Objective. To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE). Methods. One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR. Results. The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5,95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls. Conclusion. PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan.

Original languageEnglish
Pages (from-to)721-725
Number of pages5
JournalJournal of Rheumatology
Volume34
Issue number4
Publication statusPublished - Apr 2007

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Keywords

  • Programmed cell death 1
  • Programmed cell death 1 ligand
  • Programmed cell death 2 ligand
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Wang, S. C., Lin, C. H., Ou, T. T., Wu, C. C., Tsai, W. C., Hu, C. J., Liu, H. W., & Yen, J. H. (2007). Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus. Journal of Rheumatology, 34(4), 721-725.