Lifetime exposure to cigarette smoking and the development of adult-onset atopic dermatitis

C. H. Lee, H. Y. Chuang, C. H. Hong, S. K. Huang, Y. C. Chang, Y. C. Ko, H. S. Yu

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background Adult-onset atopic dermatitis (AD) has recently been recognized as a distinct disease entity, but its risk factors have not yet been clearly defined. Although gestational and perinatal exposure to tobacco smoking may be associated with the development of classic AD, the association between active/passive smoking and adult-onset AD remains controversial. Objectives To determine if exposure to smoking, including environmental tobacco smoke (ETS), is associated with the risk of adult-onset AD. Methods Tobacco smoking and exposure to ETS were measured in a case-control association analysis in 83 patients with physician-diagnosed adult-onset AD and 142 age- and sex-matched controls. Results Multiple logistic regression analyses showed that, among the potential environmental risk factors, both current and ever smoking were significant risk factors for adult-onset AD [odds ratio (OR) 4·994 and 3·619, respectively], compared with never smoking. Also, packs per year was significantly associated with adult-onset AD (OR 1·058, 95% confidence interval 1·028-1·089), suggesting a lifelong cumulative risk in current smokers. Moreover, nonsmokers with adult-onset AD reported significantly more exposure to ETS. Conclusions Early and/or current exposure to cigarette smoking may contribute cumulatively to the development of adult-onset AD. Exposure to ETS in childhood is associated with the development of adult-onset AD. Adults should be discouraged from smoking to prevent adult-onset AD in themselves and their family members.

Original languageEnglish
Pages (from-to)483-489
Number of pages7
JournalBritish Journal of Dermatology
Volume164
Issue number3
DOIs
Publication statusPublished - Mar 1 2011
Externally publishedYes

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Atopic Dermatitis
Smoking
Smoke
Tobacco
Environmental Exposure
Odds Ratio
Tobacco Smoke Pollution
Logistic Models
Regression Analysis
Confidence Intervals
Physicians

ASJC Scopus subject areas

  • Dermatology

Cite this

Lifetime exposure to cigarette smoking and the development of adult-onset atopic dermatitis. / Lee, C. H.; Chuang, H. Y.; Hong, C. H.; Huang, S. K.; Chang, Y. C.; Ko, Y. C.; Yu, H. S.

In: British Journal of Dermatology, Vol. 164, No. 3, 01.03.2011, p. 483-489.

Research output: Contribution to journalArticle

Lee, C. H. ; Chuang, H. Y. ; Hong, C. H. ; Huang, S. K. ; Chang, Y. C. ; Ko, Y. C. ; Yu, H. S. / Lifetime exposure to cigarette smoking and the development of adult-onset atopic dermatitis. In: British Journal of Dermatology. 2011 ; Vol. 164, No. 3. pp. 483-489.
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