Abstract
Background.: Both active cigarette smoking and human papillomavirus (HPV) infection are known risk factors for cervical intraepithelial neoplasm (CIN). The association between second-hand smoke (SHS) and CIN has not been conclusively determined. We conducted a community-based case-control study to estimate the relationship between SHS and CIN. Methods.: Potential study subjects were selected through Pap smear screening in Kaohsiung County, Taiwan. A total of 171 subjects with either their first case of inflammation (benign epithelial lesion) or ≥ CIN1 by biopsy confirmation were assigned to a case group; 513 normal subjects with negative findings by Pap smears or biopsies were assigned to a control group. Results.: Non-smoking women exposed to more than 20 pack-years of cigarette smoke had a significantly greater risk of developing ≥ CIN2 than unexposed non-smokers (adjusted OR = 7.2, 95% CI = 2.5-20.6). Among the women without HPV infections, the greater the severity of disease found in the groups (normal, inflammation, CIN1, to ≥ CIN2), the more likely it was for the women to be exposed to SHS, a significant increasing trend (p = 0.037). Conclusions.: In addition to HPV infection and active cigarette smoking, exposure to SHS is a major risk factor for CIN among Taiwanese women.
| Original language | English |
|---|---|
| Pages (from-to) | 181-188 |
| Number of pages | 8 |
| Journal | Gynecologic Oncology |
| Volume | 105 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 2007 |
| Externally published | Yes |
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Keywords
- A community case-control study
- Cervical intraepithelial neoplasm (CIN)
- Epidemiology
- Second-hand smoke (SHS)
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Oncology
Cite this
Lifetime cigarette smoke and second-hand smoke and cervical intraepithelial neoplasm-A community-based case-control study. / Tsai, Hsiu Ting; Tsai, Ying Mei; Yang, Sheau Fang; Wu, Kuen Yuh; Chuang, Hung Yi; Wu, Trong Neng; Ho, Chi Kung; Lin, Cheng Chieh; Kuo, Ying Se; Wu, Ming Tsang.
In: Gynecologic Oncology, Vol. 105, No. 1, 04.2007, p. 181-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lifetime cigarette smoke and second-hand smoke and cervical intraepithelial neoplasm-A community-based case-control study
AU - Tsai, Hsiu Ting
AU - Tsai, Ying Mei
AU - Yang, Sheau Fang
AU - Wu, Kuen Yuh
AU - Chuang, Hung Yi
AU - Wu, Trong Neng
AU - Ho, Chi Kung
AU - Lin, Cheng Chieh
AU - Kuo, Ying Se
AU - Wu, Ming Tsang
PY - 2007/4
Y1 - 2007/4
N2 - Background.: Both active cigarette smoking and human papillomavirus (HPV) infection are known risk factors for cervical intraepithelial neoplasm (CIN). The association between second-hand smoke (SHS) and CIN has not been conclusively determined. We conducted a community-based case-control study to estimate the relationship between SHS and CIN. Methods.: Potential study subjects were selected through Pap smear screening in Kaohsiung County, Taiwan. A total of 171 subjects with either their first case of inflammation (benign epithelial lesion) or ≥ CIN1 by biopsy confirmation were assigned to a case group; 513 normal subjects with negative findings by Pap smears or biopsies were assigned to a control group. Results.: Non-smoking women exposed to more than 20 pack-years of cigarette smoke had a significantly greater risk of developing ≥ CIN2 than unexposed non-smokers (adjusted OR = 7.2, 95% CI = 2.5-20.6). Among the women without HPV infections, the greater the severity of disease found in the groups (normal, inflammation, CIN1, to ≥ CIN2), the more likely it was for the women to be exposed to SHS, a significant increasing trend (p = 0.037). Conclusions.: In addition to HPV infection and active cigarette smoking, exposure to SHS is a major risk factor for CIN among Taiwanese women.
AB - Background.: Both active cigarette smoking and human papillomavirus (HPV) infection are known risk factors for cervical intraepithelial neoplasm (CIN). The association between second-hand smoke (SHS) and CIN has not been conclusively determined. We conducted a community-based case-control study to estimate the relationship between SHS and CIN. Methods.: Potential study subjects were selected through Pap smear screening in Kaohsiung County, Taiwan. A total of 171 subjects with either their first case of inflammation (benign epithelial lesion) or ≥ CIN1 by biopsy confirmation were assigned to a case group; 513 normal subjects with negative findings by Pap smears or biopsies were assigned to a control group. Results.: Non-smoking women exposed to more than 20 pack-years of cigarette smoke had a significantly greater risk of developing ≥ CIN2 than unexposed non-smokers (adjusted OR = 7.2, 95% CI = 2.5-20.6). Among the women without HPV infections, the greater the severity of disease found in the groups (normal, inflammation, CIN1, to ≥ CIN2), the more likely it was for the women to be exposed to SHS, a significant increasing trend (p = 0.037). Conclusions.: In addition to HPV infection and active cigarette smoking, exposure to SHS is a major risk factor for CIN among Taiwanese women.
KW - A community case-control study
KW - Cervical intraepithelial neoplasm (CIN)
KW - Epidemiology
KW - Second-hand smoke (SHS)
UR - http://www.scopus.com/inward/record.url?scp=33947309585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947309585&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2006.11.012
DO - 10.1016/j.ygyno.2006.11.012
M3 - Article
C2 - 17204311
AN - SCOPUS:33947309585
VL - 105
SP - 181
EP - 188
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 1
ER -