Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest

Wan Jung Lu, Gong Jhe Wu, Ray Jade Chen, Chao Chien Chang, Li Ming Lien, Ching Chuan Chiu, Mei Fang Tseng, Li Ting Huang, Kuan Hung Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Licochalcone A (LA), an active ingredient of licorice, has multiple biological activities, including antioxidative and anti-inflammatory activities. Although LA exerts antitumor effects in various cancer cells, its role in gliomas remains unclear. Therefore, this study determined whether LA inhibits glioma cell growth in vitro and in vivo. The present data revealed that LA effectively inhibited the growth of U87 glioma cells by inducing cell cycle arrest in the G0/G1 and G2/M phases; cell cycle arrest was attributed to the LA-mediated reduction of mRNA and protein levels of cyclins and cyclin-dependent kinases. Moreover, subcutaneous (flank) and orthotopic (brain) tumor models were used to determine the role of LA in gliomas. LA significantly alleviated tumor growth in both models. These findings indicate that LA exerts antitumor effects in gliomas in vitro and in vivo and that it is a potential agent for treating glioblastoma multiforme.

Original languageEnglish
Pages (from-to)4500-4507
Number of pages8
JournalFood and Function
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

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Cell Cycle Checkpoints
Glioma
cell growth
licorice
neoplasms
cyclin-dependent kinase
cyclins
Growth
active ingredients
anti-inflammatory activity
growth models
mitosis
bioactive properties
brain
proteins
cells
Glycyrrhiza
Cyclins
Cyclin-Dependent Kinases
cell cycle checkpoints

ASJC Scopus subject areas

  • Food Science

Cite this

Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest. / Lu, Wan Jung; Wu, Gong Jhe; Chen, Ray Jade; Chang, Chao Chien; Lien, Li Ming; Chiu, Ching Chuan; Tseng, Mei Fang; Huang, Li Ting; Lin, Kuan Hung.

In: Food and Function, Vol. 9, No. 8, 01.08.2018, p. 4500-4507.

Research output: Contribution to journalArticle

Lu, Wan Jung ; Wu, Gong Jhe ; Chen, Ray Jade ; Chang, Chao Chien ; Lien, Li Ming ; Chiu, Ching Chuan ; Tseng, Mei Fang ; Huang, Li Ting ; Lin, Kuan Hung. / Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest. In: Food and Function. 2018 ; Vol. 9, No. 8. pp. 4500-4507.
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abstract = "Licochalcone A (LA), an active ingredient of licorice, has multiple biological activities, including antioxidative and anti-inflammatory activities. Although LA exerts antitumor effects in various cancer cells, its role in gliomas remains unclear. Therefore, this study determined whether LA inhibits glioma cell growth in vitro and in vivo. The present data revealed that LA effectively inhibited the growth of U87 glioma cells by inducing cell cycle arrest in the G0/G1 and G2/M phases; cell cycle arrest was attributed to the LA-mediated reduction of mRNA and protein levels of cyclins and cyclin-dependent kinases. Moreover, subcutaneous (flank) and orthotopic (brain) tumor models were used to determine the role of LA in gliomas. LA significantly alleviated tumor growth in both models. These findings indicate that LA exerts antitumor effects in gliomas in vitro and in vivo and that it is a potential agent for treating glioblastoma multiforme.",
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AU - Lu, Wan Jung

AU - Wu, Gong Jhe

AU - Chen, Ray Jade

AU - Chang, Chao Chien

AU - Lien, Li Ming

AU - Chiu, Ching Chuan

AU - Tseng, Mei Fang

AU - Huang, Li Ting

AU - Lin, Kuan Hung

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