Leu27IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling

Chin Yi Lin; Marthandam Asokan Shibu; Renee Wen; Cecilia Hsuan Day; Ray Jade Chen; Chia Hua Kuo; Tsung Jung Ho; Vijaya Padma Viswanadha; Wei Wen Kuo; Chih Yang Huang

doi:10.1002/tox.23360

Leu²⁷IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling

Chin Yi Lin, Marthandam Asokan Shibu, Renee Wen, Cecilia Hsuan Day, Ray Jade Chen, Chia Hua Kuo, Tsung Jung Ho, Vijaya Padma Viswanadha, Wei Wen Kuo, Chih Yang Huang

Department of Surgery

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The insulin-like growth factor II receptor (IGF-IIR) induces myocardial hypertrophy under various pathological conditions like diabetes and hypertension via G protein receptors like Gαq or Gαs. Increased expression of the ligand IGF II and IGF-IIR induces pathological hypertrophy through downstream signaling mediators such as calcineurin, nuclear factor of activated T cells 3 and calcium-calmodulin (CaM)-dependent kinase II (CaMKII)-histone deacetylase 4 (HDAC4). The dried stigma of Crocus sativus L. (saffron) has a long repute as a traditional medicine against various disorders. In the present study, we have investigated whether C. sativus extract (CSE) canameliorate Leu²⁷IGF-II triggered hypertrophy and have elucidated the underlying mechanism of protection. Additionally, the effects of oleic acid (OA), an activator of calcineurin and CaMKII was investigated thereof. The results demonstrate that CSE can ameliorate Leu²⁷IGF-II-induced hypertrophy seemingly through regulation of calcineurin-NFAT3 and CaMKII-HDAC4 signaling cascade.

Original language	English
Pages (from-to)	2475-2483
Number of pages	9
Journal	Environmental Toxicology
Volume	36
Issue number	12
DOIs	https://doi.org/10.1002/tox.23360
Publication status	Published - Dec 2021

Keywords

calcineurin
CaMKII
cardiac hypertrophy
NFATc3
saffron

ASJC Scopus subject areas

Toxicology
Management, Monitoring, Policy and Law
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/tox.23360

Cite this

@article{19a43679c92d4f96b4e9c4d313231d09,

title = "Leu27IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling",

abstract = "The insulin-like growth factor II receptor (IGF-IIR) induces myocardial hypertrophy under various pathological conditions like diabetes and hypertension via G protein receptors like Gαq or Gαs. Increased expression of the ligand IGF II and IGF-IIR induces pathological hypertrophy through downstream signaling mediators such as calcineurin, nuclear factor of activated T cells 3 and calcium-calmodulin (CaM)-dependent kinase II (CaMKII)-histone deacetylase 4 (HDAC4). The dried stigma of Crocus sativus L. (saffron) has a long repute as a traditional medicine against various disorders. In the present study, we have investigated whether C. sativus extract (CSE) canameliorate Leu27IGF-II triggered hypertrophy and have elucidated the underlying mechanism of protection. Additionally, the effects of oleic acid (OA), an activator of calcineurin and CaMKII was investigated thereof. The results demonstrate that CSE can ameliorate Leu27IGF-II-induced hypertrophy seemingly through regulation of calcineurin-NFAT3 and CaMKII-HDAC4 signaling cascade.",

keywords = "calcineurin, CaMKII, cardiac hypertrophy, NFATc3, saffron",

author = "Lin, {Chin Yi} and Shibu, {Marthandam Asokan} and Renee Wen and Day, {Cecilia Hsuan} and Chen, {Ray Jade} and Kuo, {Chia Hua} and Ho, {Tsung Jung} and Viswanadha, {Vijaya Padma} and Kuo, {Wei Wen} and Huang, {Chih Yang}",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",

year = "2021",

month = dec,

doi = "10.1002/tox.23360",

language = "English",

volume = "36",

pages = "2475--2483",

journal = "Environmental Toxicology",

issn = "1520-4081",

publisher = "John Wiley and Sons Inc.",

number = "12",

}

TY - JOUR

T1 - Leu27IGF-II-induced hypertrophy in H9c2 cardiomyoblasts is ameliorated by saffron by regulation of calcineurin/NFAT and CaMKIIδ signaling

AU - Lin, Chin Yi

AU - Shibu, Marthandam Asokan

AU - Wen, Renee

AU - Day, Cecilia Hsuan

AU - Chen, Ray Jade

AU - Kuo, Chia Hua

AU - Ho, Tsung Jung

AU - Viswanadha, Vijaya Padma

AU - Kuo, Wei Wen

AU - Huang, Chih Yang

PY - 2021/12

Y1 - 2021/12

N2 - The insulin-like growth factor II receptor (IGF-IIR) induces myocardial hypertrophy under various pathological conditions like diabetes and hypertension via G protein receptors like Gαq or Gαs. Increased expression of the ligand IGF II and IGF-IIR induces pathological hypertrophy through downstream signaling mediators such as calcineurin, nuclear factor of activated T cells 3 and calcium-calmodulin (CaM)-dependent kinase II (CaMKII)-histone deacetylase 4 (HDAC4). The dried stigma of Crocus sativus L. (saffron) has a long repute as a traditional medicine against various disorders. In the present study, we have investigated whether C. sativus extract (CSE) canameliorate Leu27IGF-II triggered hypertrophy and have elucidated the underlying mechanism of protection. Additionally, the effects of oleic acid (OA), an activator of calcineurin and CaMKII was investigated thereof. The results demonstrate that CSE can ameliorate Leu27IGF-II-induced hypertrophy seemingly through regulation of calcineurin-NFAT3 and CaMKII-HDAC4 signaling cascade.

AB - The insulin-like growth factor II receptor (IGF-IIR) induces myocardial hypertrophy under various pathological conditions like diabetes and hypertension via G protein receptors like Gαq or Gαs. Increased expression of the ligand IGF II and IGF-IIR induces pathological hypertrophy through downstream signaling mediators such as calcineurin, nuclear factor of activated T cells 3 and calcium-calmodulin (CaM)-dependent kinase II (CaMKII)-histone deacetylase 4 (HDAC4). The dried stigma of Crocus sativus L. (saffron) has a long repute as a traditional medicine against various disorders. In the present study, we have investigated whether C. sativus extract (CSE) canameliorate Leu27IGF-II triggered hypertrophy and have elucidated the underlying mechanism of protection. Additionally, the effects of oleic acid (OA), an activator of calcineurin and CaMKII was investigated thereof. The results demonstrate that CSE can ameliorate Leu27IGF-II-induced hypertrophy seemingly through regulation of calcineurin-NFAT3 and CaMKII-HDAC4 signaling cascade.

KW - calcineurin

KW - CaMKII

KW - cardiac hypertrophy

KW - NFATc3

KW - saffron

UR - http://www.scopus.com/inward/record.url?scp=85114342270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85114342270&partnerID=8YFLogxK

U2 - 10.1002/tox.23360

DO - 10.1002/tox.23360

M3 - Article

C2 - 34495567

AN - SCOPUS:85114342270

SN - 1520-4081

VL - 36

SP - 2475

EP - 2483

JO - Environmental Toxicology

JF - Environmental Toxicology

IS - 12

ER -