Leukocyte mitochondria alterations after aerobic exercise in trained human subjects

Tai Ger Hsu, Kuang Ming Hsu, Chi Woon Kong, Fung Jou Lu, Hu Cheng, Kelvin Tsai

Research output: Contribution to journalArticle

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Abstract

Exercise is associated with intensity-dependent immune disturbances. Leukocyte mitochondrial alterations and apoptosis may contribute to this phenomenon. Purpose: To investigate the effects of different intensities of aerobic exercise (AE) on leukocyte mitochondrial transmembrane potential (MTP) and the propensity of apoptosis. Methods: Blood samples were collected from 12 subjects who performed AE for 3 consecutive days (35% maximal oxygen consumption (V̇O2max)). Leukocyte MTP and apoptosis were measured by flow cytometry. The subjects performed two additional sessions of AE of higher intensities (60% and 85% V̇O2max) with an intervening 4-wk washout period. The measurements were repeated during each session. Results: Leukocyte MTP declined during daily, repetitive AE at an intensity of 60% and 85% V̇O2max. Similar changes were not found during a more moderate AE (35% V̇O2max). Leukocytes increased their propensity of apoptosis a period (3-5 d) after the start of the AE. Conclusion: High-intensity AE has accumulative effects on the mitochondrial energization status and vitality of peripheral blood leukocytes. Leukocyte MTP is a potentially applicable indicator for monitoring immune distress due to overtraining.

Original languageEnglish
Pages (from-to)438-442
Number of pages5
JournalMedicine and Science in Sports and Exercise
Volume34
Issue number3
Publication statusPublished - 2002
Externally publishedYes

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Mitochondria
Leukocytes
Exercise
Membrane Potentials
Apoptosis
Immunologic Monitoring
Oxygen Consumption
Flow Cytometry

Keywords

  • Flow cytometry
  • Immunity
  • Running

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

Cite this

Leukocyte mitochondria alterations after aerobic exercise in trained human subjects. / Hsu, Tai Ger; Hsu, Kuang Ming; Kong, Chi Woon; Lu, Fung Jou; Cheng, Hu; Tsai, Kelvin.

In: Medicine and Science in Sports and Exercise, Vol. 34, No. 3, 2002, p. 438-442.

Research output: Contribution to journalArticle

Hsu, Tai Ger ; Hsu, Kuang Ming ; Kong, Chi Woon ; Lu, Fung Jou ; Cheng, Hu ; Tsai, Kelvin. / Leukocyte mitochondria alterations after aerobic exercise in trained human subjects. In: Medicine and Science in Sports and Exercise. 2002 ; Vol. 34, No. 3. pp. 438-442.
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