Leptospirosis renal disease

Chih Wei Yang, Mai Szu Wu, Ming Jeng Pan

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Leptospirosis is a re-emerging infectious disease, affecting both animals and humans worldwide. Multiple organ involvement may be encountered in leptospirosis, and early renal involvement is very common, characterized by tubulo-interstitial nephritis and tubular dysfunction. All 12 patients diagnosed in Chang Gung Memorial Hospital (Taiwan) between 1997 and 1999 had acute renal failure, with five patients requiring dialysis. Leptospira shermani is the main serovar encountered in Taiwan, and penicillin may dramatically rescue patients from multiple organ failure provided it is given early. To understand the mechanism behind tubular injuries by leptospira infection, outer membrane proteins (OMPs) extracted from pathogenic leptospira were given to tubular cells in culture. Our in vitro experiment showed that OMPs of pathogenic leptospira activate nuclear NFκB binding and stimulate downstream inducible nitric oxide (iNOS), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α) expression. These results indicate that leptospiral infection may induce tubulo-interstitial nephritis through a toxic component in the outer membrane followed by expression of inflammatory genes.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalNephrology Dialysis Transplantation
Volume16
Issue numberSUPPL. 5
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Leptospira
Leptospirosis
Kidney
Interstitial Nephritis
Taiwan
Membrane Proteins
Emerging Communicable Diseases
Multiple Organ Failure
Chemokine CCL2
Poisons
Infection
Acute Kidney Injury
Penicillins
Dialysis
Nitric Oxide
Cell Culture Techniques
Tumor Necrosis Factor-alpha
Gene Expression
Membranes
Wounds and Injuries

Keywords

  • Acute renal failure
  • Leptospirosis
  • Tubulointerstitial nephritis

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Yang, C. W., Wu, M. S., & Pan, M. J. (2001). Leptospirosis renal disease. Nephrology Dialysis Transplantation, 16(SUPPL. 5), 73-77.

Leptospirosis renal disease. / Yang, Chih Wei; Wu, Mai Szu; Pan, Ming Jeng.

In: Nephrology Dialysis Transplantation, Vol. 16, No. SUPPL. 5, 2001, p. 73-77.

Research output: Contribution to journalArticle

Yang, CW, Wu, MS & Pan, MJ 2001, 'Leptospirosis renal disease', Nephrology Dialysis Transplantation, vol. 16, no. SUPPL. 5, pp. 73-77.
Yang, Chih Wei ; Wu, Mai Szu ; Pan, Ming Jeng. / Leptospirosis renal disease. In: Nephrology Dialysis Transplantation. 2001 ; Vol. 16, No. SUPPL. 5. pp. 73-77.
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