Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia

Vincent Chin Hung Chen, Chun Hsin Chen, Yi Hang Chiu, Tsang Yaw Lin, Feng Chiao Li, Mong Liang Lu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Leptin and adiponectin are adipokines which have opposing roles in the development of insulin resistance and metabolic syndrome (MetS). Leptin/adiponectin ratio (L/A ratio) has been proposed as a good biomarker for MetS in general population. This study aimed to compare the strength of association between MetS and leptin, adiponectin and L/A ratio, as well as to assess their performance to diagnose MetS in patients with schizophrenia. Methods: Patients diagnosed with DSM-IV schizophrenia and under clozapine or olanzapine monotherapy for at least six months were recruited. We used the modified ATP III criteria for Asians to evaluate subjects for a diagnosis of MetS. Results: We recruited 262 study subjects with schizophrenia, and classified them into those with MetS (n = 87) and those without MetS (n = 175). Leptin level was positively correlated with BMI, waist circumference, and insulin level. Adiponectin level was negatively correlated with most metabolic parameters, except glucose level. L/A ratio was positively correlated with most metabolic parameters, except levels of glucose and HDL-C. Significant gender differences existed in leptin levels, adiponectin levels, and L/A ratio. Without and with adjustment of age and gender, binary logistic regression analysis showed that leptin level, adiponectin level, and L/A ratio were significantly associated with MetS. The area under curve (AUC) of L/A ratio and leptin level for MetS was 0.744 (95% CI = 0.685–0.802) and 0.666 (95% CI = 0.601–0.731). The AUC of adiponectin level for the absence of MetS was 0.717 (95% CI = 0.655–0.780). The discriminative strength of L/A ratio for MetS was better in men than in women. Conclusions: The present study results suggest that L/A ratio may be a preferential marker of metabolic syndrome in patients with schizophrenia compared to leptin or adiponectin alone.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalPsychoneuroendocrinology
Volume92
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Adiponectin
Leptin
Schizophrenia
Biomarkers
olanzapine
Area Under Curve
Social Adjustment
Glucose
Adipokines
Clozapine
Waist Circumference
Diagnostic and Statistical Manual of Mental Disorders
Insulin Resistance

Keywords

  • Adiponectin
  • Biomarker
  • Leptin
  • Metabolic syndrome
  • Schizophrenia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia. / Chen, Vincent Chin Hung; Chen, Chun Hsin; Chiu, Yi Hang; Lin, Tsang Yaw; Li, Feng Chiao; Lu, Mong Liang.

In: Psychoneuroendocrinology, Vol. 92, 01.06.2018, p. 34-40.

Research output: Contribution to journalArticle

Chen, Vincent Chin Hung ; Chen, Chun Hsin ; Chiu, Yi Hang ; Lin, Tsang Yaw ; Li, Feng Chiao ; Lu, Mong Liang. / Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia. In: Psychoneuroendocrinology. 2018 ; Vol. 92. pp. 34-40.
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abstract = "Objective: Leptin and adiponectin are adipokines which have opposing roles in the development of insulin resistance and metabolic syndrome (MetS). Leptin/adiponectin ratio (L/A ratio) has been proposed as a good biomarker for MetS in general population. This study aimed to compare the strength of association between MetS and leptin, adiponectin and L/A ratio, as well as to assess their performance to diagnose MetS in patients with schizophrenia. Methods: Patients diagnosed with DSM-IV schizophrenia and under clozapine or olanzapine monotherapy for at least six months were recruited. We used the modified ATP III criteria for Asians to evaluate subjects for a diagnosis of MetS. Results: We recruited 262 study subjects with schizophrenia, and classified them into those with MetS (n = 87) and those without MetS (n = 175). Leptin level was positively correlated with BMI, waist circumference, and insulin level. Adiponectin level was negatively correlated with most metabolic parameters, except glucose level. L/A ratio was positively correlated with most metabolic parameters, except levels of glucose and HDL-C. Significant gender differences existed in leptin levels, adiponectin levels, and L/A ratio. Without and with adjustment of age and gender, binary logistic regression analysis showed that leptin level, adiponectin level, and L/A ratio were significantly associated with MetS. The area under curve (AUC) of L/A ratio and leptin level for MetS was 0.744 (95{\%} CI = 0.685–0.802) and 0.666 (95{\%} CI = 0.601–0.731). The AUC of adiponectin level for the absence of MetS was 0.717 (95{\%} CI = 0.655–0.780). The discriminative strength of L/A ratio for MetS was better in men than in women. Conclusions: The present study results suggest that L/A ratio may be a preferential marker of metabolic syndrome in patients with schizophrenia compared to leptin or adiponectin alone.",
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AU - Chen, Vincent Chin Hung

AU - Chen, Chun Hsin

AU - Chiu, Yi Hang

AU - Lin, Tsang Yaw

AU - Li, Feng Chiao

AU - Lu, Mong Liang

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AB - Objective: Leptin and adiponectin are adipokines which have opposing roles in the development of insulin resistance and metabolic syndrome (MetS). Leptin/adiponectin ratio (L/A ratio) has been proposed as a good biomarker for MetS in general population. This study aimed to compare the strength of association between MetS and leptin, adiponectin and L/A ratio, as well as to assess their performance to diagnose MetS in patients with schizophrenia. Methods: Patients diagnosed with DSM-IV schizophrenia and under clozapine or olanzapine monotherapy for at least six months were recruited. We used the modified ATP III criteria for Asians to evaluate subjects for a diagnosis of MetS. Results: We recruited 262 study subjects with schizophrenia, and classified them into those with MetS (n = 87) and those without MetS (n = 175). Leptin level was positively correlated with BMI, waist circumference, and insulin level. Adiponectin level was negatively correlated with most metabolic parameters, except glucose level. L/A ratio was positively correlated with most metabolic parameters, except levels of glucose and HDL-C. Significant gender differences existed in leptin levels, adiponectin levels, and L/A ratio. Without and with adjustment of age and gender, binary logistic regression analysis showed that leptin level, adiponectin level, and L/A ratio were significantly associated with MetS. The area under curve (AUC) of L/A ratio and leptin level for MetS was 0.744 (95% CI = 0.685–0.802) and 0.666 (95% CI = 0.601–0.731). The AUC of adiponectin level for the absence of MetS was 0.717 (95% CI = 0.655–0.780). The discriminative strength of L/A ratio for MetS was better in men than in women. Conclusions: The present study results suggest that L/A ratio may be a preferential marker of metabolic syndrome in patients with schizophrenia compared to leptin or adiponectin alone.

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