Lemierre syndrome complicating multiple brain abscesses caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae cured by fosfomycin and meropenem combination therapy

Wen Sen Lee, Fu Der Wang, Ying Hua Shieh, Sing On Teng, Tsong Yih Ou

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A woman aged 56 years of age had a community-acquired left neck abscess and internal jugular vein thrombosis with septicemia due to extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae. Even though she was treated with intravenous meropenem, the bacteremia persisted. She was complicated with multiple brain abscesses, seizure, and leucopenia. After a combination of intravenous fosfomycin and meropenem, her clinical condition became stable. Combination treatment was continued for 2 months and she recovered. In individual cases of Lemierre syndrome with brain abscess caused by ESBL-producing Enterobacteriaceae, fosfomycin combination therapy may be the alternative choice.

Original languageEnglish
Pages (from-to)72-74
Number of pages3
JournalJournal of Microbiology, Immunology and Infection
Volume45
Issue number1
DOIs
Publication statusPublished - Feb 2012

Fingerprint

meropenem
Lemierre Syndrome
Fosfomycin
Brain Abscess
Klebsiella pneumoniae
Jugular Veins
Leukopenia
Enterobacteriaceae
Bacteremia
Abscess
Sepsis
Seizures
Thrombosis
Neck
Therapeutics

Keywords

  • Brain abscess
  • ESBL
  • Fosfomycin
  • Klebsiella pneumoniae
  • Lemierre syndrome

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

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abstract = "A woman aged 56 years of age had a community-acquired left neck abscess and internal jugular vein thrombosis with septicemia due to extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae. Even though she was treated with intravenous meropenem, the bacteremia persisted. She was complicated with multiple brain abscesses, seizure, and leucopenia. After a combination of intravenous fosfomycin and meropenem, her clinical condition became stable. Combination treatment was continued for 2 months and she recovered. In individual cases of Lemierre syndrome with brain abscess caused by ESBL-producing Enterobacteriaceae, fosfomycin combination therapy may be the alternative choice.",
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AU - Wang, Fu Der

AU - Shieh, Ying Hua

AU - Teng, Sing On

AU - Ou, Tsong Yih

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AB - A woman aged 56 years of age had a community-acquired left neck abscess and internal jugular vein thrombosis with septicemia due to extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae. Even though she was treated with intravenous meropenem, the bacteremia persisted. She was complicated with multiple brain abscesses, seizure, and leucopenia. After a combination of intravenous fosfomycin and meropenem, her clinical condition became stable. Combination treatment was continued for 2 months and she recovered. In individual cases of Lemierre syndrome with brain abscess caused by ESBL-producing Enterobacteriaceae, fosfomycin combination therapy may be the alternative choice.

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