Leiomyosarcoma of the gastric cardia and fundus

Chih Cheng Hsieh, Chih Shiun Shih, Yu Chung Wu, Biing Shiun Huang, Wen Hu Hsu, Min Hsiung Huang, Liang Shun Wang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Gastric leiomyosarcoma is rare among gastric malignancies, and only 20% of the cases are located in the gastric cardia or fundus. It has clinical manifestations different from tumors in other sites of the stomach. We reviewed cases of leiomyosarcoma of the gastric cardia or fundus to evaluate their clinicopathologic characters and patient survival. Methods. From May, 1981, to June, 1998, a total of 15 patients who underwent curative resection of leiomyosarcoma of the gastric cardia or fundus were retrospectively identified and studied. All the clinical and pathologic data were reviewed and recorded. Results. There were 11 men and four women. Their mean age was 59.1 years (range, 3773 years). Tarry stools and epigastric fullness and pain were the most common symptoms, followed by body weight loss. All 15 patients had submucosal tumors in the gastric cardia or fundus, as shown by endoscopy, barium contrast radiography and computerized tomography. The incidence of esophageal involvement by the tumors was quite low. The mean tumor size was 10 cm, ranging from 4 cm to 20 cm. Locoregional organs were involved in nine patients. The median and mean survivals were 17.8 months and 31.7 months, respectively (range, 10.1-80.1 months) after curative resection. The three-year and five-year survival rates were 53% and 22%, respectively. Conclusions. The definitive preoperative diagnosis of the tumor is difficult before surgery, even though imaging studies show positive findings. Surgical resection with an adequate safe margin of normal tissue is the treatment of choice. Tumor size, serosal invasion with locoregional organ involvement and high tumor grade were the prognostic factors in the study.

Original languageEnglish
Pages (from-to)411-417
Number of pages7
JournalChinese Medical Journal (Taipei)
Volume62
Issue number7
Publication statusPublished - Jul 1999
Externally publishedYes

Fingerprint

Gastric Fundus
Cardia
Leiomyosarcoma
Stomach
Neoplasms
Survival
Barium
Radiography
Endoscopy
Weight Loss
Survival Rate
Tomography
Body Weight
Pain

Keywords

  • Gastric cardia
  • Gastric fundus
  • Leiomyosarcoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hsieh, C. C., Shih, C. S., Wu, Y. C., Huang, B. S., Hsu, W. H., Huang, M. H., & Wang, L. S. (1999). Leiomyosarcoma of the gastric cardia and fundus. Chinese Medical Journal (Taipei), 62(7), 411-417.

Leiomyosarcoma of the gastric cardia and fundus. / Hsieh, Chih Cheng; Shih, Chih Shiun; Wu, Yu Chung; Huang, Biing Shiun; Hsu, Wen Hu; Huang, Min Hsiung; Wang, Liang Shun.

In: Chinese Medical Journal (Taipei), Vol. 62, No. 7, 07.1999, p. 411-417.

Research output: Contribution to journalArticle

Hsieh, CC, Shih, CS, Wu, YC, Huang, BS, Hsu, WH, Huang, MH & Wang, LS 1999, 'Leiomyosarcoma of the gastric cardia and fundus', Chinese Medical Journal (Taipei), vol. 62, no. 7, pp. 411-417.
Hsieh CC, Shih CS, Wu YC, Huang BS, Hsu WH, Huang MH et al. Leiomyosarcoma of the gastric cardia and fundus. Chinese Medical Journal (Taipei). 1999 Jul;62(7):411-417.
Hsieh, Chih Cheng ; Shih, Chih Shiun ; Wu, Yu Chung ; Huang, Biing Shiun ; Hsu, Wen Hu ; Huang, Min Hsiung ; Wang, Liang Shun. / Leiomyosarcoma of the gastric cardia and fundus. In: Chinese Medical Journal (Taipei). 1999 ; Vol. 62, No. 7. pp. 411-417.
@article{b68458a181544667955883d4d6f878d7,
title = "Leiomyosarcoma of the gastric cardia and fundus",
abstract = "Background. Gastric leiomyosarcoma is rare among gastric malignancies, and only 20{\%} of the cases are located in the gastric cardia or fundus. It has clinical manifestations different from tumors in other sites of the stomach. We reviewed cases of leiomyosarcoma of the gastric cardia or fundus to evaluate their clinicopathologic characters and patient survival. Methods. From May, 1981, to June, 1998, a total of 15 patients who underwent curative resection of leiomyosarcoma of the gastric cardia or fundus were retrospectively identified and studied. All the clinical and pathologic data were reviewed and recorded. Results. There were 11 men and four women. Their mean age was 59.1 years (range, 3773 years). Tarry stools and epigastric fullness and pain were the most common symptoms, followed by body weight loss. All 15 patients had submucosal tumors in the gastric cardia or fundus, as shown by endoscopy, barium contrast radiography and computerized tomography. The incidence of esophageal involvement by the tumors was quite low. The mean tumor size was 10 cm, ranging from 4 cm to 20 cm. Locoregional organs were involved in nine patients. The median and mean survivals were 17.8 months and 31.7 months, respectively (range, 10.1-80.1 months) after curative resection. The three-year and five-year survival rates were 53{\%} and 22{\%}, respectively. Conclusions. The definitive preoperative diagnosis of the tumor is difficult before surgery, even though imaging studies show positive findings. Surgical resection with an adequate safe margin of normal tissue is the treatment of choice. Tumor size, serosal invasion with locoregional organ involvement and high tumor grade were the prognostic factors in the study.",
keywords = "Gastric cardia, Gastric fundus, Leiomyosarcoma",
author = "Hsieh, {Chih Cheng} and Shih, {Chih Shiun} and Wu, {Yu Chung} and Huang, {Biing Shiun} and Hsu, {Wen Hu} and Huang, {Min Hsiung} and Wang, {Liang Shun}",
year = "1999",
month = "7",
language = "English",
volume = "62",
pages = "411--417",
journal = "Journal of the Chinese Medical Association",
issn = "1726-4901",
publisher = "Elsevier Taiwan LLC",
number = "7",

}

TY - JOUR

T1 - Leiomyosarcoma of the gastric cardia and fundus

AU - Hsieh, Chih Cheng

AU - Shih, Chih Shiun

AU - Wu, Yu Chung

AU - Huang, Biing Shiun

AU - Hsu, Wen Hu

AU - Huang, Min Hsiung

AU - Wang, Liang Shun

PY - 1999/7

Y1 - 1999/7

N2 - Background. Gastric leiomyosarcoma is rare among gastric malignancies, and only 20% of the cases are located in the gastric cardia or fundus. It has clinical manifestations different from tumors in other sites of the stomach. We reviewed cases of leiomyosarcoma of the gastric cardia or fundus to evaluate their clinicopathologic characters and patient survival. Methods. From May, 1981, to June, 1998, a total of 15 patients who underwent curative resection of leiomyosarcoma of the gastric cardia or fundus were retrospectively identified and studied. All the clinical and pathologic data were reviewed and recorded. Results. There were 11 men and four women. Their mean age was 59.1 years (range, 3773 years). Tarry stools and epigastric fullness and pain were the most common symptoms, followed by body weight loss. All 15 patients had submucosal tumors in the gastric cardia or fundus, as shown by endoscopy, barium contrast radiography and computerized tomography. The incidence of esophageal involvement by the tumors was quite low. The mean tumor size was 10 cm, ranging from 4 cm to 20 cm. Locoregional organs were involved in nine patients. The median and mean survivals were 17.8 months and 31.7 months, respectively (range, 10.1-80.1 months) after curative resection. The three-year and five-year survival rates were 53% and 22%, respectively. Conclusions. The definitive preoperative diagnosis of the tumor is difficult before surgery, even though imaging studies show positive findings. Surgical resection with an adequate safe margin of normal tissue is the treatment of choice. Tumor size, serosal invasion with locoregional organ involvement and high tumor grade were the prognostic factors in the study.

AB - Background. Gastric leiomyosarcoma is rare among gastric malignancies, and only 20% of the cases are located in the gastric cardia or fundus. It has clinical manifestations different from tumors in other sites of the stomach. We reviewed cases of leiomyosarcoma of the gastric cardia or fundus to evaluate their clinicopathologic characters and patient survival. Methods. From May, 1981, to June, 1998, a total of 15 patients who underwent curative resection of leiomyosarcoma of the gastric cardia or fundus were retrospectively identified and studied. All the clinical and pathologic data were reviewed and recorded. Results. There were 11 men and four women. Their mean age was 59.1 years (range, 3773 years). Tarry stools and epigastric fullness and pain were the most common symptoms, followed by body weight loss. All 15 patients had submucosal tumors in the gastric cardia or fundus, as shown by endoscopy, barium contrast radiography and computerized tomography. The incidence of esophageal involvement by the tumors was quite low. The mean tumor size was 10 cm, ranging from 4 cm to 20 cm. Locoregional organs were involved in nine patients. The median and mean survivals were 17.8 months and 31.7 months, respectively (range, 10.1-80.1 months) after curative resection. The three-year and five-year survival rates were 53% and 22%, respectively. Conclusions. The definitive preoperative diagnosis of the tumor is difficult before surgery, even though imaging studies show positive findings. Surgical resection with an adequate safe margin of normal tissue is the treatment of choice. Tumor size, serosal invasion with locoregional organ involvement and high tumor grade were the prognostic factors in the study.

KW - Gastric cardia

KW - Gastric fundus

KW - Leiomyosarcoma

UR - http://www.scopus.com/inward/record.url?scp=0032779237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032779237&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032779237

VL - 62

SP - 411

EP - 417

JO - Journal of the Chinese Medical Association

JF - Journal of the Chinese Medical Association

SN - 1726-4901

IS - 7

ER -