Left prefrontal repetitive transcranial magnetic stimulation impairs performance in affective go/no-go task

Felix Bermpohl, Felipe Fregni, Paulo S. Boggio, Gregor Thut, Georg Northoff, Patricia T M Otachi, Sergio P. Rigonatti, Marco A. Marcolin, Alvaro Pascual-Leone

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Functional neuroimaging studies have associated affective go/no-go function with lateral prefrontal activation, but they have not established a causal role and have not determined whether one hemisphere is predominantly engaged. In the present study, II normal volunteers underwent slow repetitive transcranial magnetic stimulation of the left and right dorsolateral prefrontal cortex, and the occipital cortex prior to performance of a picture-based affective go/no-go task. We found an interfering effect of left prefrontal repetitive transcranial magnetic stimulation compared with both right prefrontal and occipital repetitive transcranial magnetic stimulation. This impairment concerned positive and negative task stimuli to a similar extent, and tended to be greater in shift compared with nonshift blocks. Our findings demonstrate a functionally relevant lateralization of the prefrontal contribution to affective go/no-go tasks.

Original languageEnglish
Pages (from-to)615-619
Number of pages5
JournalNeuroReport
Volume16
Issue number6
DOIs
Publication statusPublished - Apr 25 2005
Externally publishedYes

Keywords

  • Affective go/no-go task
  • Categorization
  • Dorsolateral prefrontal cortex
  • Emotion
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

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