Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study

Hsin Tung, Wei Hao Lin, Peiyuan F. Hsieh, Tsuo Hung Lan, Ming Chang Chiang, Yung Yang Lin, Syu Jyun Peng

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Letter fluency task (LFT) is a tool that measures memory, executive function, and language function but lacks a definite cutoff value to define abnormalities. We used the optical signals of functional near-infrared spectroscopy (fNIRS) to study the differences in power and connectivity between the high-functioning and low-functioning participants while performing three successive LFTs, as well as the relationships between the brain network/power and LFT performance. We found that the most differentiating factor between these two groups was network topology rather than activation power. The high-functional group (7 men and 10 women) displayed higher left intra-hemispheric global efficiency, nodal strength, and shorter characteristic path length in the first section. They then demonstrated a higher power over the left Broca's area than the right corresponding area in the latter two sections. The low-LFT group (9 men and 11 women) displayed less left-lateralized connectivity and activation power. LFT performance was only related to the network topology rather than the power values, which was only presented in the low-functioning group in the second section. The direct correlation between power and connectivity primarily existed in the inter-hemispheric network, with the timing relationship also seeming to be present. In conclusion, the high-functioning group presented more prominent left-lateralized intra-hemispheric network connectivity and power activation, particularly in the Broca's area. The low-functioning group seemed to prefer using other networks, like the inter-hemispheric, rather than having a single focus on left intra-hemispheric connectivity. The network topology seemed to better reflect the LFT performance than did the power values.

Original languageEnglish
Article number810685
JournalFrontiers in Psychiatry
Volume13
DOIs
Publication statusPublished - May 20 2022

Keywords

  • connectivity
  • functional near-infrared spectroscopy (fNIRS)
  • letter fluency task (LFT)
  • power
  • verbal fluency task (VFT)

ASJC Scopus subject areas

  • Psychiatry and Mental health

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