Left atrial expansion index for predicting atrial fibrillation and in-hospital mortality after coronary artery bypass graft surgery

Wen Hwa Wang, Shih Hung Hsiao, Ko Long Lin, Chieh Jen Wu, Pei Leun Kang, Kuan Rau Chiou

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Abstract

Background: Atrial fibrillation (AF), a common complication after coronary artery bypass graft surgery (CABG), is associated with prolonged hospital stay. This prospective study assessed the accuracy of left atrial parameters and additional preoperative characteristics for predicting post-CABG AF and in-hospital mortality. Methods: A total of 197 patients without hemodynamic-significant valvular problems, who received isolated CABG, were enrolled. Echocardiography was performed before CABG. Results: Compared with patients without post-CABG AF, those with post-CABG AF were older (71 vs 64 years, p < 0.0001), had a higher incidence of CABG during index hospitalization of acute myocardial infarction and preoperative respiratory failure requiring ventilator support, lower left ventricular ejection fraction (0.41 vs 0.48, p < 0.0001), lower left atrial expansion index (52.2% vs 93.3%, p < 0.0001), and higher left ventricular filling pressure (24.2 vs 19.1 mm Hg, p < 0.0001). Multivariate analysis of preoperative variables showed that independent predictors of AF included age (odds ratio [OR], 1.064; 95% confidence interval [CI], 1.022 to 1.107 per 1-year increase; p 0.002), maximal indexed left atrial volume (OR, 1.026; 95% CI, 1.002 to 1.051 per 1 mL/m 2 increase; p 0.037) and left atrial expansion index (OR, 0.981; 95% CI, 0.962 to 0.998 per 1% increase; p 0.029). The left atrial expansion index was also significantly associated with in-hospital mortality (OR, 0.982; 95% CI, 0.951 to 0.996 per 1% increase; p 0.042). Incidence of post-CABG AF in patients with left atrial expansion index less than 120% progressively increased as left atrial expansion index decreased. Conclusions: Left atrial expansion index independently predicts post-CABG AF and in-hospital mortality.

Original languageEnglish
Pages (from-to)796-803
Number of pages8
JournalAnnals of Thoracic Surgery
Volume93
Issue number3
DOIs
Publication statusPublished - Mar 1 2012
Externally publishedYes

Fingerprint

Hospital Mortality
Coronary Artery Bypass
Atrial Fibrillation
Transplants
Odds Ratio
Confidence Intervals
Incidence
Ventricular Pressure
Mechanical Ventilators
Respiratory Insufficiency
Stroke Volume
Echocardiography
Length of Stay
Hospitalization
Multivariate Analysis
Hemodynamics
Myocardial Infarction
Prospective Studies

Keywords

  • acute myocardial infarction
  • AF
  • Am
  • AMI
  • atrial fibrillation
  • CABG
  • coronary artery bypass graft surgery
  • Em
  • LA
  • left atrial
  • left ventricular ejection fraction
  • left ventricular filling pressure
  • LVEF
  • LVFP
  • peak early-diastolic myocardial velocity
  • peak late-diastolic myocardial velocity
  • peak systolic myocardial velocity
  • receiver operating characteristic
  • ROC
  • Sm
  • TDI
  • tissue Doppler imaging

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Left atrial expansion index for predicting atrial fibrillation and in-hospital mortality after coronary artery bypass graft surgery. / Wang, Wen Hwa; Hsiao, Shih Hung; Lin, Ko Long; Wu, Chieh Jen; Kang, Pei Leun; Chiou, Kuan Rau.

In: Annals of Thoracic Surgery, Vol. 93, No. 3, 01.03.2012, p. 796-803.

Research output: Contribution to journalArticle

Wang, Wen Hwa ; Hsiao, Shih Hung ; Lin, Ko Long ; Wu, Chieh Jen ; Kang, Pei Leun ; Chiou, Kuan Rau. / Left atrial expansion index for predicting atrial fibrillation and in-hospital mortality after coronary artery bypass graft surgery. In: Annals of Thoracic Surgery. 2012 ; Vol. 93, No. 3. pp. 796-803.
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abstract = "Background: Atrial fibrillation (AF), a common complication after coronary artery bypass graft surgery (CABG), is associated with prolonged hospital stay. This prospective study assessed the accuracy of left atrial parameters and additional preoperative characteristics for predicting post-CABG AF and in-hospital mortality. Methods: A total of 197 patients without hemodynamic-significant valvular problems, who received isolated CABG, were enrolled. Echocardiography was performed before CABG. Results: Compared with patients without post-CABG AF, those with post-CABG AF were older (71 vs 64 years, p < 0.0001), had a higher incidence of CABG during index hospitalization of acute myocardial infarction and preoperative respiratory failure requiring ventilator support, lower left ventricular ejection fraction (0.41 vs 0.48, p < 0.0001), lower left atrial expansion index (52.2{\%} vs 93.3{\%}, p < 0.0001), and higher left ventricular filling pressure (24.2 vs 19.1 mm Hg, p < 0.0001). Multivariate analysis of preoperative variables showed that independent predictors of AF included age (odds ratio [OR], 1.064; 95{\%} confidence interval [CI], 1.022 to 1.107 per 1-year increase; p 0.002), maximal indexed left atrial volume (OR, 1.026; 95{\%} CI, 1.002 to 1.051 per 1 mL/m 2 increase; p 0.037) and left atrial expansion index (OR, 0.981; 95{\%} CI, 0.962 to 0.998 per 1{\%} increase; p 0.029). The left atrial expansion index was also significantly associated with in-hospital mortality (OR, 0.982; 95{\%} CI, 0.951 to 0.996 per 1{\%} increase; p 0.042). Incidence of post-CABG AF in patients with left atrial expansion index less than 120{\%} progressively increased as left atrial expansion index decreased. Conclusions: Left atrial expansion index independently predicts post-CABG AF and in-hospital mortality.",
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AU - Kang, Pei Leun

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N2 - Background: Atrial fibrillation (AF), a common complication after coronary artery bypass graft surgery (CABG), is associated with prolonged hospital stay. This prospective study assessed the accuracy of left atrial parameters and additional preoperative characteristics for predicting post-CABG AF and in-hospital mortality. Methods: A total of 197 patients without hemodynamic-significant valvular problems, who received isolated CABG, were enrolled. Echocardiography was performed before CABG. Results: Compared with patients without post-CABG AF, those with post-CABG AF were older (71 vs 64 years, p < 0.0001), had a higher incidence of CABG during index hospitalization of acute myocardial infarction and preoperative respiratory failure requiring ventilator support, lower left ventricular ejection fraction (0.41 vs 0.48, p < 0.0001), lower left atrial expansion index (52.2% vs 93.3%, p < 0.0001), and higher left ventricular filling pressure (24.2 vs 19.1 mm Hg, p < 0.0001). Multivariate analysis of preoperative variables showed that independent predictors of AF included age (odds ratio [OR], 1.064; 95% confidence interval [CI], 1.022 to 1.107 per 1-year increase; p 0.002), maximal indexed left atrial volume (OR, 1.026; 95% CI, 1.002 to 1.051 per 1 mL/m 2 increase; p 0.037) and left atrial expansion index (OR, 0.981; 95% CI, 0.962 to 0.998 per 1% increase; p 0.029). The left atrial expansion index was also significantly associated with in-hospital mortality (OR, 0.982; 95% CI, 0.951 to 0.996 per 1% increase; p 0.042). Incidence of post-CABG AF in patients with left atrial expansion index less than 120% progressively increased as left atrial expansion index decreased. Conclusions: Left atrial expansion index independently predicts post-CABG AF and in-hospital mortality.

AB - Background: Atrial fibrillation (AF), a common complication after coronary artery bypass graft surgery (CABG), is associated with prolonged hospital stay. This prospective study assessed the accuracy of left atrial parameters and additional preoperative characteristics for predicting post-CABG AF and in-hospital mortality. Methods: A total of 197 patients without hemodynamic-significant valvular problems, who received isolated CABG, were enrolled. Echocardiography was performed before CABG. Results: Compared with patients without post-CABG AF, those with post-CABG AF were older (71 vs 64 years, p < 0.0001), had a higher incidence of CABG during index hospitalization of acute myocardial infarction and preoperative respiratory failure requiring ventilator support, lower left ventricular ejection fraction (0.41 vs 0.48, p < 0.0001), lower left atrial expansion index (52.2% vs 93.3%, p < 0.0001), and higher left ventricular filling pressure (24.2 vs 19.1 mm Hg, p < 0.0001). Multivariate analysis of preoperative variables showed that independent predictors of AF included age (odds ratio [OR], 1.064; 95% confidence interval [CI], 1.022 to 1.107 per 1-year increase; p 0.002), maximal indexed left atrial volume (OR, 1.026; 95% CI, 1.002 to 1.051 per 1 mL/m 2 increase; p 0.037) and left atrial expansion index (OR, 0.981; 95% CI, 0.962 to 0.998 per 1% increase; p 0.029). The left atrial expansion index was also significantly associated with in-hospital mortality (OR, 0.982; 95% CI, 0.951 to 0.996 per 1% increase; p 0.042). Incidence of post-CABG AF in patients with left atrial expansion index less than 120% progressively increased as left atrial expansion index decreased. Conclusions: Left atrial expansion index independently predicts post-CABG AF and in-hospital mortality.

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KW - peak early-diastolic myocardial velocity

KW - peak late-diastolic myocardial velocity

KW - peak systolic myocardial velocity

KW - receiver operating characteristic

KW - ROC

KW - Sm

KW - TDI

KW - tissue Doppler imaging

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