LbL Assembly of Albumin on Nitric Oxide-Releasing Silica Nanoparticles Using Suramin, a Polyanion Drug, as an Interlayer Linker

Hung Chang Chou, Shih Jiuan Chiu, Teh Min Hu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Preformed protein corona of nanoparticles can be utilized as a promising formulation strategy for improving nano drug delivery. Nitric oxide (NO) is a labile molecule with extensive therapeutic implications. In this study, we test whether preformation of protein coatings can enhance the performance of NO-delivering nanoparticles. S-Nitroso (SNO) silica nanoparticles (SNO-SiNPs) were prepared using a nanoprecipitation method. For the first time, bovine serum albumin (BSA) was used to coat NO-releasing nanoparticles, facilitated by a polyanionic drug, suramin, under a layer-by-layer (LbL) scheme. Bare and coated nanoparticles were characterized by zeta-potential, size, and spectroscopic measurements. We demonstrate that albumin/suramin-surface coassembly has advantages in preventing particle aggregation during lyophilization, controlling NO release and exerting an enhanced anticancer effect. (Figure Presented).

Original languageEnglish
Pages (from-to)2288-2295
Number of pages8
JournalBiomacromolecules
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 10 2015

Fingerprint

Suramin
Nitric oxide
Silicon Dioxide
Albumins
Nitric Oxide
Silica
Nanoparticles
Pharmaceutical Preparations
Proteins
Zeta potential
Bovine Serum Albumin
Drug delivery
Agglomeration
polyanions
Coatings
Molecules

ASJC Scopus subject areas

  • Bioengineering
  • Materials Chemistry
  • Polymers and Plastics
  • Biomaterials

Cite this

LbL Assembly of Albumin on Nitric Oxide-Releasing Silica Nanoparticles Using Suramin, a Polyanion Drug, as an Interlayer Linker. / Chou, Hung Chang; Chiu, Shih Jiuan; Hu, Teh Min.

In: Biomacromolecules, Vol. 16, No. 8, 10.08.2015, p. 2288-2295.

Research output: Contribution to journalArticle

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