Lapatinib and platinum-based chemotherapy ameliorate breast cancer with choroidal metastasis and restore visual acuity

Uei Han Ju, Ming Ling Tsai, Chun Shu Lin, Tsu Yi Chao, Ming Shen Dai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Involvement of the central nervous system in metastatic breast cancer is a particularly dismal occurrence because of its effects on mortality and quality of life. Development of choroidal metastasis in a breast cancer patient indicates poor prognosis and has become the major life-limiting problem. Various treatment modalities for choroidal metastasis have been applied with different efficacy. Here we describe a patient with HER2-overexpressing breast cancer and limited choroidal metastasis who responded to an HER2 tyrosine kinase inhibitor after failure of radiotherapy and chemotherapy. Her visual acuity was completely and durably restored after the targeted therapy. This case provides a unique treatment experience of breast cancer with choroidal metastasis. Copyright - Il Pensiero Scientifico Editore.

Original languageEnglish
JournalTumori
Volume100
Issue number3
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Platinum
Visual Acuity
Breast Neoplasms
Neoplasm Metastasis
Drug Therapy
Protein-Tyrosine Kinases
Radiotherapy
Therapeutics
Central Nervous System
Quality of Life
Mortality
lapatinib

Keywords

  • Breast cancer
  • Choroidal metastasis
  • HER2
  • Lapatinib

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Lapatinib and platinum-based chemotherapy ameliorate breast cancer with choroidal metastasis and restore visual acuity. / Ju, Uei Han; Tsai, Ming Ling; Lin, Chun Shu; Chao, Tsu Yi; Dai, Ming Shen.

In: Tumori, Vol. 100, No. 3, 2014.

Research output: Contribution to journalArticle

Ju, Uei Han ; Tsai, Ming Ling ; Lin, Chun Shu ; Chao, Tsu Yi ; Dai, Ming Shen. / Lapatinib and platinum-based chemotherapy ameliorate breast cancer with choroidal metastasis and restore visual acuity. In: Tumori. 2014 ; Vol. 100, No. 3.
@article{fa40341742b149499323b143210c18c7,
title = "Lapatinib and platinum-based chemotherapy ameliorate breast cancer with choroidal metastasis and restore visual acuity",
abstract = "Involvement of the central nervous system in metastatic breast cancer is a particularly dismal occurrence because of its effects on mortality and quality of life. Development of choroidal metastasis in a breast cancer patient indicates poor prognosis and has become the major life-limiting problem. Various treatment modalities for choroidal metastasis have been applied with different efficacy. Here we describe a patient with HER2-overexpressing breast cancer and limited choroidal metastasis who responded to an HER2 tyrosine kinase inhibitor after failure of radiotherapy and chemotherapy. Her visual acuity was completely and durably restored after the targeted therapy. This case provides a unique treatment experience of breast cancer with choroidal metastasis. Copyright - Il Pensiero Scientifico Editore.",
keywords = "Breast cancer, Choroidal metastasis, HER2, Lapatinib",
author = "Ju, {Uei Han} and Tsai, {Ming Ling} and Lin, {Chun Shu} and Chao, {Tsu Yi} and Dai, {Ming Shen}",
year = "2014",
doi = "10.1700/1578.17232",
language = "English",
volume = "100",
journal = "Tumori",
issn = "0300-8916",
publisher = "Wichtig Publishing",
number = "3",

}

TY - JOUR

T1 - Lapatinib and platinum-based chemotherapy ameliorate breast cancer with choroidal metastasis and restore visual acuity

AU - Ju, Uei Han

AU - Tsai, Ming Ling

AU - Lin, Chun Shu

AU - Chao, Tsu Yi

AU - Dai, Ming Shen

PY - 2014

Y1 - 2014

N2 - Involvement of the central nervous system in metastatic breast cancer is a particularly dismal occurrence because of its effects on mortality and quality of life. Development of choroidal metastasis in a breast cancer patient indicates poor prognosis and has become the major life-limiting problem. Various treatment modalities for choroidal metastasis have been applied with different efficacy. Here we describe a patient with HER2-overexpressing breast cancer and limited choroidal metastasis who responded to an HER2 tyrosine kinase inhibitor after failure of radiotherapy and chemotherapy. Her visual acuity was completely and durably restored after the targeted therapy. This case provides a unique treatment experience of breast cancer with choroidal metastasis. Copyright - Il Pensiero Scientifico Editore.

AB - Involvement of the central nervous system in metastatic breast cancer is a particularly dismal occurrence because of its effects on mortality and quality of life. Development of choroidal metastasis in a breast cancer patient indicates poor prognosis and has become the major life-limiting problem. Various treatment modalities for choroidal metastasis have been applied with different efficacy. Here we describe a patient with HER2-overexpressing breast cancer and limited choroidal metastasis who responded to an HER2 tyrosine kinase inhibitor after failure of radiotherapy and chemotherapy. Her visual acuity was completely and durably restored after the targeted therapy. This case provides a unique treatment experience of breast cancer with choroidal metastasis. Copyright - Il Pensiero Scientifico Editore.

KW - Breast cancer

KW - Choroidal metastasis

KW - HER2

KW - Lapatinib

UR - http://www.scopus.com/inward/record.url?scp=84921633751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921633751&partnerID=8YFLogxK

U2 - 10.1700/1578.17232

DO - 10.1700/1578.17232

M3 - Article

C2 - 25076253

AN - SCOPUS:84921633751

VL - 100

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 3

ER -