Laparoscopy-guided myometrial biopsy in the definite diagnosis of diffuse adenomyosis

Cherng Jye Jeng, Shih Hung Huang, Jenta Shen, Chun-Shan Chou, Chii Ruey Tzeng

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: The purpose of this study was to investigate the usefulness of laparoscopy-guided myometrial biopsy in the diagnosis of diffuse adenomyosis. Methods: This prospective non-randomized study (Canadian Task Force classification II-1) was conducted in a tertiary medical center. One hundred patients who had clinical signs and symptoms strongly suggestive of adenomyosis were included as the study sample. Transvaginal sonography, serum CA-125 determination and laparoscopy-guided myometrial biopsy were performed. Results: The mean largest myometrial thickness was 3.10 ± 0.56 cm (range 2.30-4.50). The mean serum CA-125 level was 49.64 ± 38.30 U/ml (range 10.90-205.28). Of these 100 patients, adenomyosis was pathologically proven in 92 patients, small leiomyoma in four patients and myometrial hypertrophy in four patients. The sensitivity of myometrial biopsy was 98% and the specificity 100%; the positive predictive value was 100% and the negative predictive value 80%, which were superior to those of transvaginal sonography, serum CA-125 determination or the combination of both. Conclusion: Laparoscopy-guided myometrial biopsy is a valuable tool for obtaining a definite diagnosis of diffuse adenomyosis with preservation of the uterus in infertility workup or in the evaluation of dysmenorrhea or chronic pelvic pain.

Original languageEnglish
Pages (from-to)2016-2019
Number of pages4
JournalHuman Reproduction
Issue number7
Publication statusPublished - Jul 2007


  • Adenomyosis
  • Laparoscopy
  • Myometrial biopsy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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