Langerhans cell counts in oral epithelial dysplasia and their correlation to clinicopathological parameters

Yi Ping Wang, I. Chang Chen, Yu Hsueh Wu, Yang Che Wu, Hsin Ming Chen, Julia Yu-Fong Chang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Purpose Langerhans cells (LCs) are antigen presenting cells. This study assessed the LC counts in oral epithelial dysplasia (OED) and their correlation to clinicopathological parameters. Methods This study examined the LC counts in the epithelia and subepithelial connective tissues of 58 patients with OED (21 mild, 18 moderate, and 19 severe OED lesions) and 10 specimens of normal oral mucosa (NOM) by anti-S-100 protein immunostaining. Results We found that the mean LC counts in the epithelia or subepithelial connective tissues increased significantly from NOM samples through mild and moderate OED to severe OED samples. In addition, a significant correlation was found between higher mean LC counts in the dysplastic epithelia of OED samples and OED lesions with thicker epithelial layers (p < 0.001) or wider inflammatory zones (p < 0.001), and between higher mean LC counts in the subepithelial connective tissues of OED samples and OED lesions with wider inflammatory zones (p < 0.001). Moreover, the nine OED lesions with malignant transformation had a significantly lower mean LC count than the 49 OED lesions without malignant transformation. Conclusion The significant and gradual elevation in LC count from NOM through mild and moderate OED to severe OED lesions suggests an upregulation of immunosurveillance ability in OED patients during the early oral carcinogenesis process. A low LC count in OED lesions may suggest the partial loss of immunosurveillance ability against dysplastic cells; this in turn favors the malignant transformation of an OED lesion into oral cancer.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalJournal of the Formosan Medical Association
Volume116
Issue number6
DOIs
Publication statusPublished - Jun 1 2017
Externally publishedYes

Fingerprint

Langerhans Cells
Cell Count
Mouth Mucosa
Connective Tissue
Immunologic Monitoring
Epithelium
S100 Proteins
Mouth Neoplasms
Antigen-Presenting Cells
Carcinogenesis
Up-Regulation

Keywords

  • immunosurveillance
  • Langerhans cell
  • malignant transformation
  • oral carcinogenesis
  • oral epithelial dysplasia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Langerhans cell counts in oral epithelial dysplasia and their correlation to clinicopathological parameters. / Wang, Yi Ping; Chen, I. Chang; Wu, Yu Hsueh; Wu, Yang Che; Chen, Hsin Ming; Yu-Fong Chang, Julia.

In: Journal of the Formosan Medical Association, Vol. 116, No. 6, 01.06.2017, p. 457-463.

Research output: Contribution to journalArticle

Wang, Yi Ping ; Chen, I. Chang ; Wu, Yu Hsueh ; Wu, Yang Che ; Chen, Hsin Ming ; Yu-Fong Chang, Julia. / Langerhans cell counts in oral epithelial dysplasia and their correlation to clinicopathological parameters. In: Journal of the Formosan Medical Association. 2017 ; Vol. 116, No. 6. pp. 457-463.
@article{479a6eba3a454a86b5a7d41ef8e69c9a,
title = "Langerhans cell counts in oral epithelial dysplasia and their correlation to clinicopathological parameters",
abstract = "Background/Purpose Langerhans cells (LCs) are antigen presenting cells. This study assessed the LC counts in oral epithelial dysplasia (OED) and their correlation to clinicopathological parameters. Methods This study examined the LC counts in the epithelia and subepithelial connective tissues of 58 patients with OED (21 mild, 18 moderate, and 19 severe OED lesions) and 10 specimens of normal oral mucosa (NOM) by anti-S-100 protein immunostaining. Results We found that the mean LC counts in the epithelia or subepithelial connective tissues increased significantly from NOM samples through mild and moderate OED to severe OED samples. In addition, a significant correlation was found between higher mean LC counts in the dysplastic epithelia of OED samples and OED lesions with thicker epithelial layers (p < 0.001) or wider inflammatory zones (p < 0.001), and between higher mean LC counts in the subepithelial connective tissues of OED samples and OED lesions with wider inflammatory zones (p < 0.001). Moreover, the nine OED lesions with malignant transformation had a significantly lower mean LC count than the 49 OED lesions without malignant transformation. Conclusion The significant and gradual elevation in LC count from NOM through mild and moderate OED to severe OED lesions suggests an upregulation of immunosurveillance ability in OED patients during the early oral carcinogenesis process. A low LC count in OED lesions may suggest the partial loss of immunosurveillance ability against dysplastic cells; this in turn favors the malignant transformation of an OED lesion into oral cancer.",
keywords = "immunosurveillance, Langerhans cell, malignant transformation, oral carcinogenesis, oral epithelial dysplasia",
author = "Wang, {Yi Ping} and Chen, {I. Chang} and Wu, {Yu Hsueh} and Wu, {Yang Che} and Chen, {Hsin Ming} and {Yu-Fong Chang}, Julia",
year = "2017",
month = "6",
day = "1",
doi = "10.1016/j.jfma.2017.02.006",
language = "English",
volume = "116",
pages = "457--463",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "6",

}

TY - JOUR

T1 - Langerhans cell counts in oral epithelial dysplasia and their correlation to clinicopathological parameters

AU - Wang, Yi Ping

AU - Chen, I. Chang

AU - Wu, Yu Hsueh

AU - Wu, Yang Che

AU - Chen, Hsin Ming

AU - Yu-Fong Chang, Julia

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background/Purpose Langerhans cells (LCs) are antigen presenting cells. This study assessed the LC counts in oral epithelial dysplasia (OED) and their correlation to clinicopathological parameters. Methods This study examined the LC counts in the epithelia and subepithelial connective tissues of 58 patients with OED (21 mild, 18 moderate, and 19 severe OED lesions) and 10 specimens of normal oral mucosa (NOM) by anti-S-100 protein immunostaining. Results We found that the mean LC counts in the epithelia or subepithelial connective tissues increased significantly from NOM samples through mild and moderate OED to severe OED samples. In addition, a significant correlation was found between higher mean LC counts in the dysplastic epithelia of OED samples and OED lesions with thicker epithelial layers (p < 0.001) or wider inflammatory zones (p < 0.001), and between higher mean LC counts in the subepithelial connective tissues of OED samples and OED lesions with wider inflammatory zones (p < 0.001). Moreover, the nine OED lesions with malignant transformation had a significantly lower mean LC count than the 49 OED lesions without malignant transformation. Conclusion The significant and gradual elevation in LC count from NOM through mild and moderate OED to severe OED lesions suggests an upregulation of immunosurveillance ability in OED patients during the early oral carcinogenesis process. A low LC count in OED lesions may suggest the partial loss of immunosurveillance ability against dysplastic cells; this in turn favors the malignant transformation of an OED lesion into oral cancer.

AB - Background/Purpose Langerhans cells (LCs) are antigen presenting cells. This study assessed the LC counts in oral epithelial dysplasia (OED) and their correlation to clinicopathological parameters. Methods This study examined the LC counts in the epithelia and subepithelial connective tissues of 58 patients with OED (21 mild, 18 moderate, and 19 severe OED lesions) and 10 specimens of normal oral mucosa (NOM) by anti-S-100 protein immunostaining. Results We found that the mean LC counts in the epithelia or subepithelial connective tissues increased significantly from NOM samples through mild and moderate OED to severe OED samples. In addition, a significant correlation was found between higher mean LC counts in the dysplastic epithelia of OED samples and OED lesions with thicker epithelial layers (p < 0.001) or wider inflammatory zones (p < 0.001), and between higher mean LC counts in the subepithelial connective tissues of OED samples and OED lesions with wider inflammatory zones (p < 0.001). Moreover, the nine OED lesions with malignant transformation had a significantly lower mean LC count than the 49 OED lesions without malignant transformation. Conclusion The significant and gradual elevation in LC count from NOM through mild and moderate OED to severe OED lesions suggests an upregulation of immunosurveillance ability in OED patients during the early oral carcinogenesis process. A low LC count in OED lesions may suggest the partial loss of immunosurveillance ability against dysplastic cells; this in turn favors the malignant transformation of an OED lesion into oral cancer.

KW - immunosurveillance

KW - Langerhans cell

KW - malignant transformation

KW - oral carcinogenesis

KW - oral epithelial dysplasia

UR - http://www.scopus.com/inward/record.url?scp=85014845133&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014845133&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2017.02.006

DO - 10.1016/j.jfma.2017.02.006

M3 - Article

C2 - 28292622

AN - SCOPUS:85014845133

VL - 116

SP - 457

EP - 463

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 6

ER -