Lamotrigine adjunctive therapy in children with refractory epilepsy: A medical center study

Shyi Jou Chen, Kai Ping Chang, Tai-Tong Wong, Shang Yeong Kwan, Mu Ling Hsu, Chih Chien Wang

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4 Citations (Scopus)

Abstract

The aim of this study was to investigate the effects of adjunctive lamotrigine (LTG) in refractory epilepsy in Taiwan, especially including patients who had undergone ineffective epileptic surgeries. Totally, 27 recruited children and adolescents with refractory epilepsy were treated with LTG add-on therapy, but 23 were enrolled statistically during 2 years period trial. Ten of the 23 patients (43.5%), including 5 undergoing epileptic surgeries, before had a >50% reduction in seizure frequency. Surprisingly, LTG was found to have excellent response in six patients with Lennox-Gastaut Syndrome (LGS), 5 of whom had received anterior 2/3 callosotomy prior to the trial. Non-seizure related positive effects were presented in 3 patients, including greater alertness and attentiveness in 2 patients and improvement in mood in one patient. This open trial found that LTG was an effective add-on anti-epileptic drug (AED) in Taiwanese children and adolescents with refractory epilepsy and in cases with LGS even after ineffective callosotomy.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalActa Paediatrica Taiwanica
Volume47
Issue number3
Publication statusPublished - May 1 2006
Externally publishedYes

Keywords

  • Callosotomy
  • Lamotrigine
  • Lennox-Gastaut syndrome
  • Refractory epilepsy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Chen, S. J., Chang, K. P., Wong, T-T., Kwan, S. Y., Hsu, M. L., & Wang, C. C. (2006). Lamotrigine adjunctive therapy in children with refractory epilepsy: A medical center study. Acta Paediatrica Taiwanica, 47(3), 123-126.