Lag time method to delay drug release to various sites in the gastrointestinal tract

Ching Cheng Kao, Shou Chiung Chen, Ming Thau Sheu

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The lag times delayed by the hydration of various thicknesses of films were studied in an attempt to deliver drugs to various sites in the gastrointestinal (GI) tract. In a theoretical simulation, it was found that the lag time could be controlled by varying the thickness of the coated polymer, which was equivalent to the amount of polymer coated assuming that the density of the dry polymer was constant. A higher ratio of drug solubility relative to the dosing amount promoted rapid release of drug after the lag period. Diltiazem hydrochloride was selected as a model drug with high and pH-independent water solubility. In vitro dissolution in the pH change medium demonstrated that the release pattern of diltiazem hydrochloride from pellets coated with various thicknesses of Eudragit RS film was kept unchanged. Drug release exhibited a lag period followed afterwards by instantaneous release. The relationship between the lag time and the square of the amount of polymer coated, as well as that between the release rate at steady state and the inverse of the amount of polymer coated, appeared to be linear as predicted.

Original languageEnglish
Pages (from-to)263-270
Number of pages8
JournalJournal of Controlled Release
Volume44
Issue number2-3
DOIs
Publication statusPublished - Feb 17 1997

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Keywords

  • delayed release
  • diltiazem HCl
  • Eudragit RS
  • film coating
  • lag time

ASJC Scopus subject areas

  • Pharmaceutical Science

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