Lactobacillus reuteri GMNL-263 reduces hyperlipidaemia and the heart failure process in high-calorie diet-fed induced heart dysfunction in rats

Po Hsiang Liao, Wei Wen Kuo, Chia Hua Kuo, Yu Lan Yeh, Chia Yao Shen, Ya Hui Chen, Ray Jade Chen, V. Vijaya Padma, Yi Hsing Chen, Chih Yang Huang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Probiotics are reported to provide protective health benefits against various disorders. In this study, we established a high-calorie diet animal model with a diet prepared by fortifying normal diet with soybean oil and condensed milk and the animals were supplemented with different dose of probiotic Lactobacillus reuteri GMNL-263(Lr263) for 8 weeks to investigate the protective function. We measured the lipid levels in plasma, liver and faecal; heart weight, function and collagen accumulation and biochemical markers of cardiac disease. Lr263 reversed high-calorie diet-induced cardiac weight gain, systolic malfunction and prevented heart inflammation by decreasing inflammation proteins NF-κB and COX-2. Moreover, Lr263 reduced cardiac eccentric hypertrophy and the levels of cardiac fibrosis markers CTGF and SP1 in high-calorie diet-fed rat hearts. Thus, Lr263 is considered as a functional food that provides anti-inflammatory, anti-hypertrophic, anti-fibrotic functions and identified specific biologic effects in reducing the characteristics of the high-calorie diet-induced progression to heart failure.

Original languageEnglish
Pages (from-to)226-235
Number of pages10
JournalJournal of Functional Foods
Volume20
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Fibrosis
  • High-calorie diet
  • Hypertrophy
  • Inflammation
  • Probiotic

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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