Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice

Yi Ming Chen, Li Wei, Yen Shuo Chiu, Yi Ju Hsu, Tsung Yu Tsai, Ming Fu Wang, Chi Chang Huang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Lactobacillus plantarum (L. plantarum) is a well-known probiotic among the ingestedmicroorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host). However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n = 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 x 108, or 1.03 x 109 colony-forming units/kg/day, designated the vehicle, LP10-1X and LP10-5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight (%). LP10 supplementation dose-dependently increased grip strength (p < 0.0001) and endurance swimming time (p < 0.001) and decreased levels of serum lactate (p < 0.0001), ammonia (p < 0.0001), creatine kinase (p = 0.0118), and glucose (p = 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long-term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health-promotion, performance-improvement, and anti-fatigue effects.

Original languageEnglish
JournalNutrients
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 7 2016

Fingerprint

Lactobacillus plantarum
exercise
Muscles
muscles
mice
Probiotics
blood serum
probiotics
Fatigue
Slow-Twitch Muscle Fibers
Exercise
health promotion
Blood Urea Nitrogen
Hand Strength
creatine kinase
Creatine Kinase
urea nitrogen
Health Promotion
intestinal microorganisms
Ammonia

Keywords

  • Exercise performance
  • Forelimb grip strength
  • Gastrocnemius muscles
  • Lactobacillus plantarum TWK10

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Chen, Y. M., Wei, L., Chiu, Y. S., Hsu, Y. J., Tsai, T. Y., Wang, M. F., & Huang, C. C. (2016). Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice. Nutrients, 8(4). https://doi.org/10.3390/nu8040205

Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice. / Chen, Yi Ming; Wei, Li; Chiu, Yen Shuo; Hsu, Yi Ju; Tsai, Tsung Yu; Wang, Ming Fu; Huang, Chi Chang.

In: Nutrients, Vol. 8, No. 4, 07.04.2016.

Research output: Contribution to journalArticle

Chen, Yi Ming ; Wei, Li ; Chiu, Yen Shuo ; Hsu, Yi Ju ; Tsai, Tsung Yu ; Wang, Ming Fu ; Huang, Chi Chang. / Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice. In: Nutrients. 2016 ; Vol. 8, No. 4.
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