Lack of association between plasma Dehydroepiandrosterone Sulfate (DHEA-S) levels and depression in hemodialysis patients: A cross-sectional study

Heng Jung Hsu, Chih Ken Chen, Cheng Cheng Hsiao, I. Wen Wu, Chiao Yin Sun, Chia Chi Chou, Chin Chan Lee, Chi Jen Tsai, Mai Szu Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. Method: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. Results: The prevalence of depression in our studied hemodialysis population is 37.5% (30/80). The DHEA-S level was 1138.1 ± 1216.9 ng/mL in male patients and 502.1 ± 389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8 ± 1127.1 ng/mL vs. 769.3 ± 848.3 ng/mL, P = 0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. Conclusion: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients.

Original languageEnglish
Pages (from-to)733-739
Number of pages7
JournalExperimental Gerontology
Volume44
Issue number11
DOIs
Publication statusPublished - Nov 2009
Externally publishedYes

Fingerprint

Dehydroepiandrosterone Sulfate
Renal Dialysis
Cross-Sectional Studies
Depression
Plasmas
Dialysis
Ferritins
Medical problems
Metabolism
Serum Albumin
Urea
Albumins
Hemoglobins
Alcohols
Hormones
Serum
Population
Diabetes Mellitus
Body Mass Index
Smoking

Keywords

  • Depression
  • DHEA-S
  • End-stage renal disease
  • Hemodialysis
  • Steroid hormone

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

Cite this

Lack of association between plasma Dehydroepiandrosterone Sulfate (DHEA-S) levels and depression in hemodialysis patients : A cross-sectional study. / Hsu, Heng Jung; Chen, Chih Ken; Hsiao, Cheng Cheng; Wu, I. Wen; Sun, Chiao Yin; Chou, Chia Chi; Lee, Chin Chan; Tsai, Chi Jen; Wu, Mai Szu.

In: Experimental Gerontology, Vol. 44, No. 11, 11.2009, p. 733-739.

Research output: Contribution to journalArticle

Hsu, Heng Jung ; Chen, Chih Ken ; Hsiao, Cheng Cheng ; Wu, I. Wen ; Sun, Chiao Yin ; Chou, Chia Chi ; Lee, Chin Chan ; Tsai, Chi Jen ; Wu, Mai Szu. / Lack of association between plasma Dehydroepiandrosterone Sulfate (DHEA-S) levels and depression in hemodialysis patients : A cross-sectional study. In: Experimental Gerontology. 2009 ; Vol. 44, No. 11. pp. 733-739.
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abstract = "Objective: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. Method: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. Results: The prevalence of depression in our studied hemodialysis population is 37.5{\%} (30/80). The DHEA-S level was 1138.1 ± 1216.9 ng/mL in male patients and 502.1 ± 389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8 ± 1127.1 ng/mL vs. 769.3 ± 848.3 ng/mL, P = 0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. Conclusion: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients.",
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T1 - Lack of association between plasma Dehydroepiandrosterone Sulfate (DHEA-S) levels and depression in hemodialysis patients

T2 - A cross-sectional study

AU - Hsu, Heng Jung

AU - Chen, Chih Ken

AU - Hsiao, Cheng Cheng

AU - Wu, I. Wen

AU - Sun, Chiao Yin

AU - Chou, Chia Chi

AU - Lee, Chin Chan

AU - Tsai, Chi Jen

AU - Wu, Mai Szu

PY - 2009/11

Y1 - 2009/11

N2 - Objective: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. Method: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. Results: The prevalence of depression in our studied hemodialysis population is 37.5% (30/80). The DHEA-S level was 1138.1 ± 1216.9 ng/mL in male patients and 502.1 ± 389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8 ± 1127.1 ng/mL vs. 769.3 ± 848.3 ng/mL, P = 0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. Conclusion: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients.

AB - Objective: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. Method: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. Results: The prevalence of depression in our studied hemodialysis population is 37.5% (30/80). The DHEA-S level was 1138.1 ± 1216.9 ng/mL in male patients and 502.1 ± 389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8 ± 1127.1 ng/mL vs. 769.3 ± 848.3 ng/mL, P = 0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. Conclusion: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients.

KW - Depression

KW - DHEA-S

KW - End-stage renal disease

KW - Hemodialysis

KW - Steroid hormone

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