Lack of association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki disease in the Taiwanese children

Ho Chang Kuo, Ying Jui Lin, Suh Hang Hank Juo, Yu Wen Hsu, Wei Chiao Chen, Kuender D. Yang, Chi Di Liang, Shengyu Yang, Mei Chyn Chao, Hong Ren Yu, Shouyan Wang, Li Yan Lin, Wei Chiao Chang

Research output: Contribution to journalArticle

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Abstract

Objective Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/ CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/ CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalJournal of Clinical Immunology
Volume31
Issue number4
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

Fingerprint

Mucocutaneous Lymph Node Syndrome
Inositol 1,4,5-trisphosphate 3-kinase
Genes
Intravenous Immunoglobulins
Disease Susceptibility
Single Nucleotide Polymorphism
Coronary Vessels
Systemic Vasculitis
Calcium Channels
Gene Frequency
Haplotypes
Genotype
Therapeutics
Population

Keywords

  • Coronary artery lesions
  • Intravenous immunoglobulin
  • Kawasaki disease
  • ORAI1/CRACM1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lack of association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki disease in the Taiwanese children. / Kuo, Ho Chang; Lin, Ying Jui; Juo, Suh Hang Hank; Hsu, Yu Wen; Chen, Wei Chiao; Yang, Kuender D.; Liang, Chi Di; Yang, Shengyu; Chao, Mei Chyn; Yu, Hong Ren; Wang, Shouyan; Lin, Li Yan; Chang, Wei Chiao.

In: Journal of Clinical Immunology, Vol. 31, No. 4, 08.2011, p. 650-655.

Research output: Contribution to journalArticle

Kuo, HC, Lin, YJ, Juo, SHH, Hsu, YW, Chen, WC, Yang, KD, Liang, CD, Yang, S, Chao, MC, Yu, HR, Wang, S, Lin, LY & Chang, WC 2011, 'Lack of association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki disease in the Taiwanese children', Journal of Clinical Immunology, vol. 31, no. 4, pp. 650-655. https://doi.org/10.1007/s10875-011-9524-8
Kuo, Ho Chang ; Lin, Ying Jui ; Juo, Suh Hang Hank ; Hsu, Yu Wen ; Chen, Wei Chiao ; Yang, Kuender D. ; Liang, Chi Di ; Yang, Shengyu ; Chao, Mei Chyn ; Yu, Hong Ren ; Wang, Shouyan ; Lin, Li Yan ; Chang, Wei Chiao. / Lack of association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki disease in the Taiwanese children. In: Journal of Clinical Immunology. 2011 ; Vol. 31, No. 4. pp. 650-655.
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abstract = "Objective Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/ CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/ CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.",
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AU - Kuo, Ho Chang

AU - Lin, Ying Jui

AU - Juo, Suh Hang Hank

AU - Hsu, Yu Wen

AU - Chen, Wei Chiao

AU - Yang, Kuender D.

AU - Liang, Chi Di

AU - Yang, Shengyu

AU - Chao, Mei Chyn

AU - Yu, Hong Ren

AU - Wang, Shouyan

AU - Lin, Li Yan

AU - Chang, Wei Chiao

PY - 2011/8

Y1 - 2011/8

N2 - Objective Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/ CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/ CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.

AB - Objective Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/ CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/ CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.

KW - Coronary artery lesions

KW - Intravenous immunoglobulin

KW - Kawasaki disease

KW - ORAI1/CRACM1

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