Label-free nanofluidic preconcentration with multi-operational modes by loop currents monitoring for biological application

Pei Shan Chung, Yen-Lin Liu, K. P. Liao, Y. J. Fan, K. B. Sung, Horn Jiunn Sheen, Wei Cheng Tian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

A novel method, "loop currents monitoring", was proposed for interpreting the onset of preconcentration mechanism and the behaviors of a preconcentrated plug of a nanofluidic preconcentrator without fluorescent labeling. Three operational modes of preconcentrated plugs during the preconcentration process were explained by loop currents of the chip and flow profiles including electroosmotic flow (EOF) and nanochannel-induced backflow (EOF of the second kind). It is demonstrated that our nanofluidic preconcentrator has the capability to precisely control and rapidly preconcentrate label-free proteins.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1403-1405
Number of pages3
Volume3
ISBN (Print)9781632666246
Publication statusPublished - 2013
Externally publishedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: Oct 27 2013Oct 31 2013

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period10/27/1310/31/13

Keywords

  • Electroosmotic flow
  • Ion concentration polarization (ICP)
  • Label-free nanofluidic sample preconcentration
  • Loop currents monitoring
  • Permselective nanochannel
  • Space charge region

ASJC Scopus subject areas

  • Bioengineering

Fingerprint Dive into the research topics of 'Label-free nanofluidic preconcentration with multi-operational modes by loop currents monitoring for biological application'. Together they form a unique fingerprint.

  • Cite this

    Chung, P. S., Liu, Y-L., Liao, K. P., Fan, Y. J., Sung, K. B., Sheen, H. J., & Tian, W. C. (2013). Label-free nanofluidic preconcentration with multi-operational modes by loop currents monitoring for biological application. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (Vol. 3, pp. 1403-1405). Chemical and Biological Microsystems Society.