Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Chin Lin Hsien, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.

Original languageEnglish
Pages (from-to)515-517
Number of pages3
JournalTetrahedron Letters
Issue number4
Publication statusPublished - Jan 26 2011


  • Calocedrus macrolepis
  • Cupressaceae
  • Terpenoid
  • X-ray crystallography

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery


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