Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

Chin Lin Hsien, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.

Original languageEnglish
Pages (from-to)515-517
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number4
DOIs
Publication statusPublished - Jan 26 2011

Fingerprint

Cupressaceae
KB Cells
Sesquiterpenes
Diterpenes
Terpenes
Taiwan
Skeleton
Inhibitory Concentration 50
Squamous Cell Carcinoma
Acids

Keywords

  • Calocedrus macrolepis
  • Cupressaceae
  • Terpenoid
  • X-ray crystallography

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Hsien, C. L., Tseng, M. H., Pan, R. N., Chang, J. Y., Kuo, C. C., Li, Z-H., & Kuo, Y. H. (2011). Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana. Tetrahedron Letters, 52(4), 515-517. https://doi.org/10.1016/j.tetlet.2010.11.101

Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana. / Hsien, Chin Lin; Tseng, Mei Hwei; Pan, Ryh Nan; Chang, Jang Yang; Kuo, Ching Chuan; Li, Zong-Huei; Kuo, Yueh Hsiung.

In: Tetrahedron Letters, Vol. 52, No. 4, 26.01.2011, p. 515-517.

Research output: Contribution to journalArticle

Hsien, CL, Tseng, MH, Pan, RN, Chang, JY, Kuo, CC, Li, Z-H & Kuo, YH 2011, 'Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana', Tetrahedron Letters, vol. 52, no. 4, pp. 515-517. https://doi.org/10.1016/j.tetlet.2010.11.101
Hsien, Chin Lin ; Tseng, Mei Hwei ; Pan, Ryh Nan ; Chang, Jang Yang ; Kuo, Ching Chuan ; Li, Zong-Huei ; Kuo, Yueh Hsiung. / Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana. In: Tetrahedron Letters. 2011 ; Vol. 52, No. 4. pp. 515-517.
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