Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

Yu Jen Kuo, Ping Chun Hsiao, Li Jie Zhang, Ming Der Wu, Yu Han Liang, Hsiu O. Ho, Yao Haur Kuo

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μ M against several human tumor cell lines.

Original languageEnglish
Pages (from-to)1097-1101
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number6
DOIs
Publication statusPublished - Jun 26 2009

Fingerprint

Alpinia
Diterpenes
Macrophages
Glycosides
Nitric Oxide
Tumor Cell Line
Flavonoids
Tumors
Cells
labdane

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages. / Kuo, Yu Jen; Hsiao, Ping Chun; Zhang, Li Jie; Wu, Ming Der; Liang, Yu Han; Ho, Hsiu O.; Kuo, Yao Haur.

In: Journal of Natural Products, Vol. 72, No. 6, 26.06.2009, p. 1097-1101.

Research output: Contribution to journalArticle

Kuo, Yu Jen ; Hsiao, Ping Chun ; Zhang, Li Jie ; Wu, Ming Der ; Liang, Yu Han ; Ho, Hsiu O. ; Kuo, Yao Haur. / Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages. In: Journal of Natural Products. 2009 ; Vol. 72, No. 6. pp. 1097-1101.
@article{7987b5cd05924e1a9f889c029b6767b6,
title = "Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages",
abstract = "Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μ M against several human tumor cell lines.",
author = "Kuo, {Yu Jen} and Hsiao, {Ping Chun} and Zhang, {Li Jie} and Wu, {Ming Der} and Liang, {Yu Han} and Ho, {Hsiu O.} and Kuo, {Yao Haur}",
year = "2009",
month = "6",
day = "26",
doi = "10.1021/np900019n",
language = "English",
volume = "72",
pages = "1097--1101",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "6",

}

TY - JOUR

T1 - Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages

AU - Kuo, Yu Jen

AU - Hsiao, Ping Chun

AU - Zhang, Li Jie

AU - Wu, Ming Der

AU - Liang, Yu Han

AU - Ho, Hsiu O.

AU - Kuo, Yao Haur

PY - 2009/6/26

Y1 - 2009/6/26

N2 - Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μ M against several human tumor cell lines.

AB - Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μ M against several human tumor cell lines.

UR - http://www.scopus.com/inward/record.url?scp=67650216173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650216173&partnerID=8YFLogxK

U2 - 10.1021/np900019n

DO - 10.1021/np900019n

M3 - Article

VL - 72

SP - 1097

EP - 1101

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 6

ER -