K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea

Han Pin Kuo, Juliette A.L. Rohde, Peter J. Barnes, Duncan F. Rogers

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit metacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalEuropean Journal of Pharmacology
Volume215
Issue number2-3
DOIs
Publication statusPublished - May 14 1992
Externally publishedYes

Fingerprint

Goblet Cells
Trachea
Cromakalim
Guinea Pigs
Cholinergic Agents
Vagus Nerve
Capsaicin
Potassium Channels
Substance P
Smoke
Tobacco Products
Inhalation
Electric Stimulation

Keywords

  • Goblet cell secretion
  • K channel activators

ASJC Scopus subject areas

  • Pharmacology

Cite this

K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea. / Kuo, Han Pin; Rohde, Juliette A.L.; Barnes, Peter J.; Rogers, Duncan F.

In: European Journal of Pharmacology, Vol. 215, No. 2-3, 14.05.1992, p. 297-299.

Research output: Contribution to journalArticle

Kuo, Han Pin ; Rohde, Juliette A.L. ; Barnes, Peter J. ; Rogers, Duncan F. / K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea. In: European Journal of Pharmacology. 1992 ; Vol. 215, No. 2-3. pp. 297-299.
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