K+ channel activator inhibition of neurogenic goblet cell secretion in guinea pig trachea

Han Pin Kuo, Juliette A.L. Rohde, Peter J. Barnes, Duncan F. Rogers

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A potassium (K+) channel activator, BRL 38227, inhibited goblet cell secretion in guinea-pig trachea induced by either electrical stimulation of the vagus nerves or acute inhalation of cigarette smoke, two stimuli which activate both cholinergic nerves and capsaicin-sensitive sensory nerves. BRL 38227 failed to inhibit metacholine- or substance P-induced goblet cell secretion which suggests that K+ channel activators inhibit neurogenic goblet cell secretion via a prejunctional effect on cholinergic and sensory nerves.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalEuropean Journal of Pharmacology
Volume215
Issue number2-3
DOIs
Publication statusPublished - May 14 1992
Externally publishedYes

Keywords

  • Goblet cell secretion
  • K channel activators

ASJC Scopus subject areas

  • Pharmacology

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