Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis

J. H. Yen, C. H. Lin, W. C. Tsai, C. C. Wu, T. T. Ou, C. J. Hu, H. W. Liu

Research output: Contribution to journalArticle

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Abstract

Objective: To investigate the role of the killer cell immunoglobulin-like receptor (KIR) gene's repertoire in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. Methods: KIR genotypes were determined in 122 patients with RA and 96 healthy controls by the sequence-specific primer polymerase chain reaction (SSP-PCR) method. Human leucocyte antigen (HLA)-C genotyping was also performed simultaneously in 72 patients and 66 controls by the SSP-PCR method. Results: The total carriage frequency of KIR 2DS4 regardless of corresponding HLA-Cw4 was significantly increased in RA patients compared with controls [p <0.001, odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.4, Pc <0.01]. The total carriage frequency of KIR 2DL1 regardless of corresponding HLA-C also tended to be increased in RA patients (p <0.02, OR = 2.1, 95% CI = 1.2-3.9, Pc = not significant). The frequency of KIR 2DS4 with corresponding HLA-Cw4 was increased in RA patients in comparison with controls (p = 0.02, OR = 3.2, 95% CI = 1.1-9.4). Moreover, the association of RA with KIR 2DS4 depended on the presence of the corresponding HLA-Cw4. Conclusions: KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalScandinavian Journal of Rheumatology
Volume35
Issue number2
DOIs
Publication statusPublished - Apr 1 2006

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KIR Receptors
Rheumatoid Arthritis
HLA Antigens
Genes
Odds Ratio
Confidence Intervals
Taiwan
KIR2DL1 Receptors
Polymerase Chain Reaction
Genotype

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis. / Yen, J. H.; Lin, C. H.; Tsai, W. C.; Wu, C. C.; Ou, T. T.; Hu, C. J.; Liu, H. W.

In: Scandinavian Journal of Rheumatology, Vol. 35, No. 2, 01.04.2006, p. 124-127.

Research output: Contribution to journalArticle

Yen, J. H. ; Lin, C. H. ; Tsai, W. C. ; Wu, C. C. ; Ou, T. T. ; Hu, C. J. ; Liu, H. W. / Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis. In: Scandinavian Journal of Rheumatology. 2006 ; Vol. 35, No. 2. pp. 124-127.
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abstract = "Objective: To investigate the role of the killer cell immunoglobulin-like receptor (KIR) gene's repertoire in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. Methods: KIR genotypes were determined in 122 patients with RA and 96 healthy controls by the sequence-specific primer polymerase chain reaction (SSP-PCR) method. Human leucocyte antigen (HLA)-C genotyping was also performed simultaneously in 72 patients and 66 controls by the SSP-PCR method. Results: The total carriage frequency of KIR 2DS4 regardless of corresponding HLA-Cw4 was significantly increased in RA patients compared with controls [p <0.001, odds ratio (OR) = 1.9, 95{\%} confidence interval (CI) = 1.1-3.4, Pc <0.01]. The total carriage frequency of KIR 2DL1 regardless of corresponding HLA-C also tended to be increased in RA patients (p <0.02, OR = 2.1, 95{\%} CI = 1.2-3.9, Pc = not significant). The frequency of KIR 2DS4 with corresponding HLA-Cw4 was increased in RA patients in comparison with controls (p = 0.02, OR = 3.2, 95{\%} CI = 1.1-9.4). Moreover, the association of RA with KIR 2DS4 depended on the presence of the corresponding HLA-Cw4. Conclusions: KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan.",
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