Abstract
Objective: To investigate the role of the killer cell immunoglobulin-like receptor (KIR) gene's repertoire in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. Methods: KIR genotypes were determined in 122 patients with RA and 96 healthy controls by the sequence-specific primer polymerase chain reaction (SSP-PCR) method. Human leucocyte antigen (HLA)-C genotyping was also performed simultaneously in 72 patients and 66 controls by the SSP-PCR method. Results: The total carriage frequency of KIR 2DS4 regardless of corresponding HLA-Cw4 was significantly increased in RA patients compared with controls [p <0.001, odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.4, Pc <0.01]. The total carriage frequency of KIR 2DL1 regardless of corresponding HLA-C also tended to be increased in RA patients (p <0.02, OR = 2.1, 95% CI = 1.2-3.9, Pc = not significant). The frequency of KIR 2DS4 with corresponding HLA-Cw4 was increased in RA patients in comparison with controls (p = 0.02, OR = 3.2, 95% CI = 1.1-9.4). Moreover, the association of RA with KIR 2DS4 depended on the presence of the corresponding HLA-Cw4. Conclusions: KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan.
| Original language | English |
|---|---|
| Pages (from-to) | 124-127 |
| Number of pages | 4 |
| Journal | Scandinavian Journal of Rheumatology |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1 2006 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis. / Yen, J. H.; Lin, C. H.; Tsai, W. C.; Wu, C. C.; Ou, T. T.; Hu, C. J.; Liu, H. W.
In: Scandinavian Journal of Rheumatology, Vol. 35, No. 2, 01.04.2006, p. 124-127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis
AU - Yen, J. H.
AU - Lin, C. H.
AU - Tsai, W. C.
AU - Wu, C. C.
AU - Ou, T. T.
AU - Hu, C. J.
AU - Liu, H. W.
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Objective: To investigate the role of the killer cell immunoglobulin-like receptor (KIR) gene's repertoire in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. Methods: KIR genotypes were determined in 122 patients with RA and 96 healthy controls by the sequence-specific primer polymerase chain reaction (SSP-PCR) method. Human leucocyte antigen (HLA)-C genotyping was also performed simultaneously in 72 patients and 66 controls by the SSP-PCR method. Results: The total carriage frequency of KIR 2DS4 regardless of corresponding HLA-Cw4 was significantly increased in RA patients compared with controls [p <0.001, odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.4, Pc <0.01]. The total carriage frequency of KIR 2DL1 regardless of corresponding HLA-C also tended to be increased in RA patients (p <0.02, OR = 2.1, 95% CI = 1.2-3.9, Pc = not significant). The frequency of KIR 2DS4 with corresponding HLA-Cw4 was increased in RA patients in comparison with controls (p = 0.02, OR = 3.2, 95% CI = 1.1-9.4). Moreover, the association of RA with KIR 2DS4 depended on the presence of the corresponding HLA-Cw4. Conclusions: KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan.
AB - Objective: To investigate the role of the killer cell immunoglobulin-like receptor (KIR) gene's repertoire in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. Methods: KIR genotypes were determined in 122 patients with RA and 96 healthy controls by the sequence-specific primer polymerase chain reaction (SSP-PCR) method. Human leucocyte antigen (HLA)-C genotyping was also performed simultaneously in 72 patients and 66 controls by the SSP-PCR method. Results: The total carriage frequency of KIR 2DS4 regardless of corresponding HLA-Cw4 was significantly increased in RA patients compared with controls [p <0.001, odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.4, Pc <0.01]. The total carriage frequency of KIR 2DL1 regardless of corresponding HLA-C also tended to be increased in RA patients (p <0.02, OR = 2.1, 95% CI = 1.2-3.9, Pc = not significant). The frequency of KIR 2DS4 with corresponding HLA-Cw4 was increased in RA patients in comparison with controls (p = 0.02, OR = 3.2, 95% CI = 1.1-9.4). Moreover, the association of RA with KIR 2DS4 depended on the presence of the corresponding HLA-Cw4. Conclusions: KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan.
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U2 - 10.1080/03009740500381252
DO - 10.1080/03009740500381252
M3 - Article
VL - 35
SP - 124
EP - 127
JO - Scandinavian Journal of Rheumatology
JF - Scandinavian Journal of Rheumatology
SN - 0300-9742
IS - 2
ER -