Abstract

Background: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Methods: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan. The control group comprised 35,494 randomly selected people without renal cancer matched by age and gender to the patients in the study group. ORs were calculated to assess the association of chronic hepatitis virus infection with renal cancer by using logistic regression analysis. Results: Renal cancer was associated with HBV and HCV infection (OR 1.38, 95% CI 1.24-1.54; OR 1.24, 95% CI 1.07-1.44, respectively). An analysis stratified by gender and age revealed that young male HBV carriers had a higher risk of renal cancer compared with men without viral hepatitis (age <55 years: OR 1.94, 95% CI 1.57-2.39; 55≤ age <64 years: OR 1.40, 95% CI 1.05-1.86). Male HCV-infected patients aged <55 years (OR 1.90, 95% CI 1.11-3.26) and female HCV carriers aged between 55 and 64 years (OR 1.59, 95% CI 1.00-2.53) had a significantly higher risk of renal cancer compared with their counterparts. Conclusions: Renal cancer is significantly associated with chronic hepatitis infection, particularly in younger HBV-infected men.

Original languageEnglish
Pages (from-to)22-31
Number of pages10
JournalAmerican Journal of Nephrology
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Kidney Neoplasms
Chronic Hepatitis
Virus Diseases
Population
Hepatitis B virus
Hepacivirus
Hepatitis Viruses
Hepatitis
National Health Programs
Insurance
Taiwan
Case-Control Studies
Logistic Models
Regression Analysis
Databases
Control Groups

Keywords

  • Hepatitis B virus
  • Hepatitis C virus
  • Renal cancer

ASJC Scopus subject areas

  • Nephrology

Cite this

Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific : A Population-Based Analysis. / Lin, Yu Shan; Yeh, Chih Ching; Lin, Yen Chung; Su, Chien Tien; Sung, Fung Chang; Chang, Shih Ni; Liu, Yun Ru; Su, Fu Hsiung.

In: American Journal of Nephrology, Vol. 45, No. 1, 01.01.2017, p. 22-31.

Research output: Contribution to journalArticle

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title = "Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis",
abstract = "Background: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Methods: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan. The control group comprised 35,494 randomly selected people without renal cancer matched by age and gender to the patients in the study group. ORs were calculated to assess the association of chronic hepatitis virus infection with renal cancer by using logistic regression analysis. Results: Renal cancer was associated with HBV and HCV infection (OR 1.38, 95{\%} CI 1.24-1.54; OR 1.24, 95{\%} CI 1.07-1.44, respectively). An analysis stratified by gender and age revealed that young male HBV carriers had a higher risk of renal cancer compared with men without viral hepatitis (age <55 years: OR 1.94, 95{\%} CI 1.57-2.39; 55≤ age <64 years: OR 1.40, 95{\%} CI 1.05-1.86). Male HCV-infected patients aged <55 years (OR 1.90, 95{\%} CI 1.11-3.26) and female HCV carriers aged between 55 and 64 years (OR 1.59, 95{\%} CI 1.00-2.53) had a significantly higher risk of renal cancer compared with their counterparts. Conclusions: Renal cancer is significantly associated with chronic hepatitis infection, particularly in younger HBV-infected men.",
keywords = "Hepatitis B virus, Hepatitis C virus, Renal cancer",
author = "Lin, {Yu Shan} and Yeh, {Chih Ching} and Lin, {Yen Chung} and Su, {Chien Tien} and Sung, {Fung Chang} and Chang, {Shih Ni} and Liu, {Yun Ru} and Su, {Fu Hsiung}",
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T1 - Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific

T2 - A Population-Based Analysis

AU - Lin, Yu Shan

AU - Yeh, Chih Ching

AU - Lin, Yen Chung

AU - Su, Chien Tien

AU - Sung, Fung Chang

AU - Chang, Shih Ni

AU - Liu, Yun Ru

AU - Su, Fu Hsiung

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Methods: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan. The control group comprised 35,494 randomly selected people without renal cancer matched by age and gender to the patients in the study group. ORs were calculated to assess the association of chronic hepatitis virus infection with renal cancer by using logistic regression analysis. Results: Renal cancer was associated with HBV and HCV infection (OR 1.38, 95% CI 1.24-1.54; OR 1.24, 95% CI 1.07-1.44, respectively). An analysis stratified by gender and age revealed that young male HBV carriers had a higher risk of renal cancer compared with men without viral hepatitis (age <55 years: OR 1.94, 95% CI 1.57-2.39; 55≤ age <64 years: OR 1.40, 95% CI 1.05-1.86). Male HCV-infected patients aged <55 years (OR 1.90, 95% CI 1.11-3.26) and female HCV carriers aged between 55 and 64 years (OR 1.59, 95% CI 1.00-2.53) had a significantly higher risk of renal cancer compared with their counterparts. Conclusions: Renal cancer is significantly associated with chronic hepatitis infection, particularly in younger HBV-infected men.

AB - Background: The association of renal cancer with viral hepatitis infection remains unclear. Using an insurance data set, this population-based case-control study evaluated the association of renal cancer with chronic hepatitis virus infection in an endemic area of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. Methods: We enrolled 17,747 patients with renal cancer during the period from 2000 to 2011 from the National Health Insurance Research Database of Taiwan. The control group comprised 35,494 randomly selected people without renal cancer matched by age and gender to the patients in the study group. ORs were calculated to assess the association of chronic hepatitis virus infection with renal cancer by using logistic regression analysis. Results: Renal cancer was associated with HBV and HCV infection (OR 1.38, 95% CI 1.24-1.54; OR 1.24, 95% CI 1.07-1.44, respectively). An analysis stratified by gender and age revealed that young male HBV carriers had a higher risk of renal cancer compared with men without viral hepatitis (age <55 years: OR 1.94, 95% CI 1.57-2.39; 55≤ age <64 years: OR 1.40, 95% CI 1.05-1.86). Male HCV-infected patients aged <55 years (OR 1.90, 95% CI 1.11-3.26) and female HCV carriers aged between 55 and 64 years (OR 1.59, 95% CI 1.00-2.53) had a significantly higher risk of renal cancer compared with their counterparts. Conclusions: Renal cancer is significantly associated with chronic hepatitis infection, particularly in younger HBV-infected men.

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Renal cancer

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