Kawasaki disease and subsequent risk of allergic diseases: A population-based matched cohort study

Ho Chang Kuo, Wei Chiao Chang, Kuender D. Yang, Hong Ren Yu, Chih Lu Wang, Shu Chen Ho, Chun Yuh Yang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The risk of allergic diseases among Kawasaki disease (KD) patients relative to the general population is not known. The aim of this study was to perform a population-based cohort study to investigate the risk of allergic diseases among children after KD in Taiwan- a country with the third highest incidence of KD in the world.Methods: Data were obtained from the Taiwan National Health Insurance Research Database. In total, 253 patients who were 5 years of age or younger and had a first-time hospitalization with a diagnosis of KD between 1997 and 2005 were included as the study cohort and 1,012 non-KD patients matched for age and sex were included as comparison cohort. Multivariate Cox proportional hazard regression model was used to adjust for confounding and to compare the 6-year allergic-free survival rate between these two cohorts.Results: The incidence rate of allergic diseases (184.66 per 1000 person-year) was significantly higher in the KD cohort than in the control cohort (124.99 per 1000 person-years). After adjusting for potential confounders, the adjusted hazard ratios of asthma and allergic rhinitis were 1.51 (95% confidence interval = 1.17-1.95) and 1.30 (95% confidence interval = 1.04-1.62), respectively.Conclusion: We conclude that KD patients were at an increased risk for allergic diseases compared with the comparison cohort.

Original languageEnglish
Article number38
JournalBMC Pediatrics
Volume13
Issue number1
DOIs
Publication statusPublished - Mar 23 2013

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Mucocutaneous Lymph Node Syndrome
Cohort Studies
Population
Taiwan
Confidence Intervals
Incidence
National Health Programs
Proportional Hazards Models
Hospitalization
Asthma
Survival Rate
Databases
Research

Keywords

  • Allergic disease
  • Cohort study
  • Kawasaki disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Kawasaki disease and subsequent risk of allergic diseases : A population-based matched cohort study. / Kuo, Ho Chang; Chang, Wei Chiao; Yang, Kuender D.; Yu, Hong Ren; Wang, Chih Lu; Ho, Shu Chen; Yang, Chun Yuh.

In: BMC Pediatrics, Vol. 13, No. 1, 38, 23.03.2013.

Research output: Contribution to journalArticle

Kuo, Ho Chang ; Chang, Wei Chiao ; Yang, Kuender D. ; Yu, Hong Ren ; Wang, Chih Lu ; Ho, Shu Chen ; Yang, Chun Yuh. / Kawasaki disease and subsequent risk of allergic diseases : A population-based matched cohort study. In: BMC Pediatrics. 2013 ; Vol. 13, No. 1.
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