Jet nebulisation: Influence of dynamic conditions and nebuliser on nebulisation duality. Application to the α1 protease inhibitor

M. P. Flament, P. Leterme, T. Burnouf, A. T. Gayot

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The use of nebulisers lacks standardisation, which may account for certain inefficiency. As part of a study of α 1 protease inhibitor (α1 PI) nebulisation for pulmonary administration, we studied the influence of technological parameters that is to say the nebuliser and the dynamic conditions (airflow and pressure) on nebulisation quality. The quality of nebulisation is evaluated by measurement of the percentage of droplets below 5.79 μm, the quantity of α1 PI nebulised, the quantity of α1 PI likely to reach the lungs and nebulisation time. The use of different dynamic conditions results in variable nebulisation quality. Depending upon the power of the compressor and the type of nebuliser, drug delivery varies. The association of high airflow and high pressure improves the respirable fraction and compliance by decreasing nebulisation time. Although droplet size is a commonly used parameter, it is not sufficient to forecast efficiency. It must be associated with the quantity of drug nebulised and, to a lesser extent, nebulisation time. The nebuliser is also to be taken into consideration. The characteristics of the constituent nebuliser elements, that is to say liquid and air tube orifices, size and shape of the reservoir, shape and position of the impartion system, are preponderant on nebulisation quality.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalInternational Journal of Pharmaceutics
Volume148
Issue number1
DOIs
Publication statusPublished - Mar 14 1997
Externally publishedYes

    Fingerprint

Keywords

  • α1 Protease inhibitor
  • Droplet size
  • Dynamic conditions
  • Nebulisation time
  • Nebuliser
  • Quantity of drug nebulised

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this