Janus kinase-1 and 3 in ankylosing spondylitis

Hsien Tzung Liao, Tzu Hao Li, Chun Hsiung Chen, Hung An Chen, Wei Sheng Chen, Chien Chih Lai, Chung Tei Chou, Chang Youh Tsai

Research output: Contribution to journalArticle

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Abstract

Background/purpose: To investigate the Janus kinase-1 and 3 (JAK-1 and 3) expression in peripheral blood mononuclear cells (PBMCs) in ankylosing spondylitis (AS). Methods: The levels of JAK-1 and JAK-3 mRNA in PBMCs, CD3+ T cells and CD14+ monocytes were measured by RT-PCR in 52 AS patients and 31 healthy controls (HCs). The demographic features, BASDAI, BASFI, HLA-B27, ESR, CRP and serum immunoglobulin A (IgA) level were recorded and correlated with the JAK-1 & JAK-3 transcripts in patients and HCs as appropriate. Results: JAK-1 and JAK-3 expression in PB CD3+ T cells plus CD14+ monocytes was significantly higher in AS patients than in HCs (p < 0.05). There is a positive correlation between JAK-1 expression in CD3+ T cells plus CD14+ monocytes and ESR, CRP, IgA, HLA-B27, peripheral arthritis, enthesitis and uveitis (all p < 0.05), respectively. JAK-1 transcript was also increased in CD14+ monocytes from patients and correlated well with ESR and CRP as the disease deteriorated. Conversely, JAK-1 was negatively correlated to chest expansion. Area under the curve of standard receiver operating characteristic suggested that JAK-1 transcript in CD3+ T cells plus CD14+ monocytes is better to predict the higher BASDAI (>4) and BASFI (>4) than ESR or CRP in AS patients. Conclusion: In AS, JAK-1 expression in PB cells rather than ESR or CRP might be regarded as a bio-marker for monitoring disease activity and functional index in AS. These findings have also suggested that JAK-1 and JAK-3 expression may play a role in the inflammatory processes in patients with AS.

Original languageEnglish
JournalJournal of the Formosan Medical Association
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Janus Kinase 3
Janus Kinase 1
Ankylosing Spondylitis
Monocytes
Blood Cells
T-Lymphocytes
HLA-B27 Antigen
Environmental Monitoring
Immunoglobulin A
Demography
Polymerase Chain Reaction
Messenger RNA

Keywords

  • Acute-phase reactant
  • Ankylosing spondylitis
  • Janus kinase (JAK)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liao, H. T., Li, T. H., Chen, C. H., Chen, H. A., Chen, W. S., Lai, C. C., ... Tsai, C. Y. (Accepted/In press). Janus kinase-1 and 3 in ankylosing spondylitis. Journal of the Formosan Medical Association. https://doi.org/10.1016/j.jfma.2018.02.001

Janus kinase-1 and 3 in ankylosing spondylitis. / Liao, Hsien Tzung; Li, Tzu Hao; Chen, Chun Hsiung; Chen, Hung An; Chen, Wei Sheng; Lai, Chien Chih; Chou, Chung Tei; Tsai, Chang Youh.

In: Journal of the Formosan Medical Association, 01.01.2018.

Research output: Contribution to journalArticle

Liao, HT, Li, TH, Chen, CH, Chen, HA, Chen, WS, Lai, CC, Chou, CT & Tsai, CY 2018, 'Janus kinase-1 and 3 in ankylosing spondylitis', Journal of the Formosan Medical Association. https://doi.org/10.1016/j.jfma.2018.02.001
Liao, Hsien Tzung ; Li, Tzu Hao ; Chen, Chun Hsiung ; Chen, Hung An ; Chen, Wei Sheng ; Lai, Chien Chih ; Chou, Chung Tei ; Tsai, Chang Youh. / Janus kinase-1 and 3 in ankylosing spondylitis. In: Journal of the Formosan Medical Association. 2018.
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AU - Chen, Hung An

AU - Chen, Wei Sheng

AU - Lai, Chien Chih

AU - Chou, Chung Tei

AU - Tsai, Chang Youh

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