Janus kinase-1 and 3 in ankylosing spondylitis

Hsien Tzung Liao, Tzu Hao Li, Chun Hsiung Chen, Hung An Chen, Wei Sheng Chen, Chien Chih Lai, Chung Tei Chou, Chang Youh Tsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background/purpose: To investigate the Janus kinase-1 and 3 (JAK-1 and 3) expression in peripheral blood mononuclear cells (PBMCs) in ankylosing spondylitis (AS). Methods: The levels of JAK-1 and JAK-3 mRNA in PBMCs, CD3+ T cells and CD14+ monocytes were measured by RT-PCR in 52 AS patients and 31 healthy controls (HCs). The demographic features, BASDAI, BASFI, HLA-B27, ESR, CRP and serum immunoglobulin A (IgA) level were recorded and correlated with the JAK-1 & JAK-3 transcripts in patients and HCs as appropriate. Results: JAK-1 and JAK-3 expression in PB CD3+ T cells plus CD14+ monocytes was significantly higher in AS patients than in HCs (p < 0.05). There is a positive correlation between JAK-1 expression in CD3+ T cells plus CD14+ monocytes and ESR, CRP, IgA, HLA-B27, peripheral arthritis, enthesitis and uveitis (all p < 0.05), respectively. JAK-1 transcript was also increased in CD14+ monocytes from patients and correlated well with ESR and CRP as the disease deteriorated. Conversely, JAK-1 was negatively correlated to chest expansion. Area under the curve of standard receiver operating characteristic suggested that JAK-1 transcript in CD3+ T cells plus CD14+ monocytes is better to predict the higher BASDAI (>4) and BASFI (>4) than ESR or CRP in AS patients. Conclusion: In AS, JAK-1 expression in PB cells rather than ESR or CRP might be regarded as a bio-marker for monitoring disease activity and functional index in AS. These findings have also suggested that JAK-1 and JAK-3 expression may play a role in the inflammatory processes in patients with AS.

Original languageEnglish
JournalJournal of the Formosan Medical Association
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • Acute-phase reactant
  • Ankylosing spondylitis
  • Janus kinase (JAK)

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Janus kinase-1 and 3 in ankylosing spondylitis'. Together they form a unique fingerprint.

  • Cite this

    Liao, H. T., Li, T. H., Chen, C. H., Chen, H. A., Chen, W. S., Lai, C. C., Chou, C. T., & Tsai, C. Y. (Accepted/In press). Janus kinase-1 and 3 in ankylosing spondylitis. Journal of the Formosan Medical Association. https://doi.org/10.1016/j.jfma.2018.02.001