IVF versus ICSI in sibling oocytes from patients with polycystic ovarian syndrome: A randomized controlled trial

Jiann-Loung Hwang, Kok Min Seow, Yu Hung Lin, Bih Chwen Hsieh, Lee Wen Huang, Heng Ju Chen, Shih Chia Huang, Chin Yu Chen, Pei Hsin Chen, Chii Ruey Tzeng

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26 Citations (Scopus)

Abstract

Background: This study compares the fertilization rate and embryonic development of oocytes randomly inseminated by conventional IVF or ICSI in patients with polycystic ovarian syndrome (PCOS) and normozoospermic semen during IVF cycles. Methods: Sibling oocytes were randomized to be inseminated either by ICSI or IVF. Fertilization rate (two pronuclei/COC), day 2 embryonic morphology and rate of development were assessed. Results: A total of 1089 cumulus-oocyte complexes (COC) were collected in 60 cycles (mean ± SD, 18.2 ± 7.2). Totals of 541 and 548 COC were inseminated by IVF and ICSI respectively, with a significantly higher fertilization rate in the ICSI group (ICSI versus IVF, 72.3 ± 15.5 versus 44.8 ± 25.1%). No fertilization failure occurred in the group of oocytes inseminated by ICSI, whereas the COC in nine patients (15%) inseminated by IVF had complete fertilization failure. The day 2 embryonic morphology and rate of development were not different regardless of the insemination method. Conclusions: Our results suggested that another randomized controlled study, randomizing patients instead of sibling oocytes, should be undertaken to compare the pregnancy rate per started cycle and to see whether ICSI should be performed on all, or at least on a portion of, oocytes for patients with PCOS undergoing IVF cycles.

Original languageEnglish
Pages (from-to)1261-1265
Number of pages5
JournalHuman Reproduction
Volume20
Issue number5
DOIs
Publication statusPublished - May 2005

Keywords

  • ICSI
  • IVF
  • PCOS
  • Sibling oocytes

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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  • Cite this

    Hwang, J-L., Seow, K. M., Lin, Y. H., Hsieh, B. C., Huang, L. W., Chen, H. J., Huang, S. C., Chen, C. Y., Chen, P. H., & Tzeng, C. R. (2005). IVF versus ICSI in sibling oocytes from patients with polycystic ovarian syndrome: A randomized controlled trial. Human Reproduction, 20(5), 1261-1265. https://doi.org/10.1093/humrep/deh786