Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population

Ho-Chang Kuo, Kuender D. Yang, Suh-Hang Hank Juo, Chi-Di Liang, Wei-Chiao Chen, Yu-Shiuan Wang, Chih-Hung Lee, Edward Hsi, Hong-Ren Yu, Peng-Yeong Woon, I-Chun Lin, Chien-Fu Huang, Daw-Yang Hwang, Chiu-Ping Lee, Li-Yan Lin, Wei Pin Chang, Wei-Chiao Chang

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Abstract

Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

Original languageEnglish
Article numbere17370
JournalPLoS One
Volume6
Issue number4
DOIs
Publication statusPublished - 2011
Externally publishedYes

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Mucocutaneous Lymph Node Syndrome
Polymorphism
single nucleotide polymorphism
Single Nucleotide Polymorphism
Nucleotides
aneurysm
Population
genetic polymorphism
vasculitis
meta-analysis
odds ratio
genotyping
Aneurysm
etiology
confidence interval
disease control
Disease control
Japan
alleles
Systemic Vasculitis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population. / Kuo, Ho-Chang; Yang, Kuender D.; Juo, Suh-Hang Hank; Liang, Chi-Di; Chen, Wei-Chiao; Wang, Yu-Shiuan; Lee, Chih-Hung; Hsi, Edward; Yu, Hong-Ren; Woon, Peng-Yeong; Lin, I-Chun; Huang, Chien-Fu; Hwang, Daw-Yang; Lee, Chiu-Ping; Lin, Li-Yan; Chang, Wei Pin; Chang, Wei-Chiao.

In: PLoS One, Vol. 6, No. 4, e17370, 2011.

Research output: Contribution to journalArticle

Kuo, H-C, Yang, KD, Juo, S-HH, Liang, C-D, Chen, W-C, Wang, Y-S, Lee, C-H, Hsi, E, Yu, H-R, Woon, P-Y, Lin, I-C, Huang, C-F, Hwang, D-Y, Lee, C-P, Lin, L-Y, Chang, WP & Chang, W-C 2011, 'Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population', PLoS One, vol. 6, no. 4, e17370. https://doi.org/10.1371/journal.pone.0017370
Kuo, Ho-Chang ; Yang, Kuender D. ; Juo, Suh-Hang Hank ; Liang, Chi-Di ; Chen, Wei-Chiao ; Wang, Yu-Shiuan ; Lee, Chih-Hung ; Hsi, Edward ; Yu, Hong-Ren ; Woon, Peng-Yeong ; Lin, I-Chun ; Huang, Chien-Fu ; Hwang, Daw-Yang ; Lee, Chiu-Ping ; Lin, Li-Yan ; Chang, Wei Pin ; Chang, Wei-Chiao. / Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population. In: PLoS One. 2011 ; Vol. 6, No. 4.
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abstract = "Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95{\%} Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.",
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AU - Wang, Yu-Shiuan

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AU - Lee, Chiu-Ping

AU - Lin, Li-Yan

AU - Chang, Wei Pin

AU - Chang, Wei-Chiao

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N2 - Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

AB - Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) is responsible for susceptibility to KD. We collected DNA samples from 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) for genotyping ITPKC. In this study, no significant association was noted for the ITPKC polymorphism (rs28493229) between the controls and KD patients, although the CC genotype was overrepresented. We further combined our data with previously published case/control KD studies in the Taiwanese population and performed a meta-analysis. A significant association between rs28493229 and KD was found (Odds Ratio:1.36, 95% Confidence Interval 1.12-1.66). Importantly, a significant association was obtained between rs28493229 and KD patients with aneurysm formation (P = 0.001, under the recessive model). Taken together, our results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.

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